Timing of Insulin Glargine 300 U/ML: Does It Really Matter in Terms of Efficacy and Safety at Insulin Initiation?

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Background: The timing of insulin administration, particularly for long-acting insulins like glargine 300 U/mL (Gla-300), plays a critical role in diabetes management. choice between daytime and nighttime administration Gla-300 is nuanced decision that should be tailored to each patient's unique circumstances. This study aims compare the efficacy safety profile initiation with when administered during day versus at night adult type 2 mellitus (T2DM) patients. Methods: A retrospective observational included records T2DM patients initiated on follow-up data three months. Cases complete medical records, including hemoglobin A1C (HbA1C) levels, fasting plasma glucose (FPG), post-prandial (PPPG), incidence hypoglycemic events, were included. Data pertaining glycaemic control safety, extracted categorized into two groups based administration. Records evaluated over months results statistically analysed. Results: total 169 patients, matched baseline characteristics, showed significant reduction indices from third month. However, intergroup difference was non-significant suggesting (morning vs. night) does not significantly impact effectiveness lowering glycemic indices. Incidences overall events numerically lesser those morning dosing 13.09% as compared 21.17%. Nocturnal hypoglycaemia 3.57% 7.05% observed. these differences insignificant (p> 0.05). Conclusion: Timing initiation, dosing, nocturnal lower Gla-300, though it significant. An individualized approach selection therapy essential optimizing minimizing hypoglycemia risk.

Язык: Английский

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The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes in Jordan: The PACT-MEA Study

Diabetes Therapy, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

This study investigated the prevalence and clinical management of atherosclerotic cardiovascular disease (ASCVD) ASCVD risk in patients with type 2 diabetes (T2D) Jordan. PACT-MEA (NCT05317845) was a non-interventional, cross-sectional, observational adults T2D recruited seven countries across Middle East Africa. In Jordan, assessments were conducted at ten sites, three primary care secondary settings. The Jordan cohort included 576 individuals (27.8% care, 72.2% settings), similarly represented by male female patients, mean age 59.7 ± 11.7 years median duration 10.0 years. established (eASCVD) 26.2% overall (95% CI: 22.8–30.0) 21.9% 27.9% settings, respectively 16.1–28.9, 23.8–32.4), higher than that observed regional analysis. By European Society Cardiology 2021 criteria, 66.0% classified as high 33.3% very (which eASCVD). Use renin–angiotensin system inhibitors, statins, cardioprotective antidiabetic medication None participants achieved all guideline recommendations respect to factor control, body mass index, exercise, pharmacotherapy. More one-quarter had ASCVD, nearly high/very risk. These findings suggest need for multifactorial approaches reduction this population within both URL: https://www.clinicaltrials.gov ; Unique identifier: NCT05317845.

Язык: Английский

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Revealing the Hidden Impacts: Insights into Biological Aging and Long-Term Effects in Pauci- and Asymptomatic COVID-19 Healthcare Workers

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8056 - 8056

Опубликована: Июль 24, 2024

This study explores the role of inflammation and oxidative stress, hallmarks COVID-19, in accelerating cellular biological aging. We investigated early molecular markers—DNA methylation age (DNAmAge) telomere length (TL)—in blood leukocytes, nasal cells (NCs), induced sputum (IS) one year post-infection pauci- asymptomatic healthcare workers (HCWs) infected during first pandemic wave (February–May 2020), compared to COPD patients, model for “aged lung”. Data from questionnaires, Work Ability Index (WAI), analyses, autonomic cardiac balance assessments, heart rate variability (HRV), pulmonary function tests were collected. Elevated leukocyte DNAmAge significantly correlated with advancing age, male sex, daytime work, an aged phenotype characterized by chronic diseases, elevated LDL glycemia levels, medications affecting HRV, declines lung function, WAI, lymphocyte count, hemoglobin HRV (p < 0.05). Increasing job positions involving intensive patient contact, higher counts collectively contributed shortened TL Notably, HCWs exhibited accelerated aging IS both leukocytes ≤ 0.05) NCs 0.001) biologically older than patients These findings suggest need monitor COVID-19 survivors, who represent majority general population.

Язык: Английский

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Factors affecting suboptimal maturation of autogenous arteriovenous fistula in elderly patients with diabetes:A narrative review

Heliyon, Год журнала: 2024, Номер 10(15), С. e35766 - e35766

Опубликована: Авг. 1, 2024

Autogenous arteriovenous fistula (AVF) is considered the preferred vascular access choice for individuals undergoing maintenance hemodialysis (MHD) and widely utilized in China, as reported by Dialysis Outcomes Practice Patterns Study. Despite its popularity, significant incidence of poor AVF maturation often leads to need central venous catheter insertion, increasing risk complications like superior vena cava stenosis catheter-related infections, which turn raises overall mortality risk. With prevalence diabetes rising globally among elderly diabetic kidney disease being a leading cause end-stage renal necessitating replacement therapy, our retrospective review aims explore various factors affecting this specific patient population. While there have been numerous studies examining MHD patients, including issues failure, patency loss, stenosis, thrombosis, maturation, other influencing factors, remains gap large-scale clinical focusing on immature specifically patients. This paper delves into pathophysiological mechanisms, diagnostic criteria, unique considerations surrounding distinguishing them from general Our literature reveals that patients exhibit higher immaturity compared Additionally, exists continuing discourse regarding several aspects related group, dialysis access, timing surgery, surgical site selection. Furthermore, we delve management strategies within group with goal providing evidence-based guidance establishment functional

Язык: Английский

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Revealing the Hidden Impacts: Insights into Biological Aging and Long-Term Effects in Pauci- and Asymptomatic COVID-19 Healthcare Workers

Опубликована: Июль 4, 2024

This study explores the role of inflammation and oxidative stress, hallmarks COVID-19, in accelerating cellular biological aging. We investigated early molecular markers—DNA methylation age (DNAmAge) telomere length (TL)—in blood leukocytes, nasal cells (NC), induced sputum (IS) one-year post-infection pauci- asymptomatic healthcare workers (HCWs) infected during first pandemic wave (February-May 2020), compared to COPD patients, model for &quot;aged lung&quot;. Data by questionnaires, Work Ability Index (WAI), analyses, autonomic cardiac balance assessments, heart rate variability (HRV), pulmonary function tests were collected. Elevated leukocyte DNAmAge significantly correlated with advancing age, male gender, daytime work, an aged phenotype characterized chronic diseases, elevated LDL glycemia levels, medications affecting HRV, declines lung function, WAI, lymphocyte count, hemoglobin HRV (p&amp;lt;0.05). Increasing job positions involving intensive patient contact, higher counts collectively contributed shortened TL Notably, HCWs exhibited accelerated aging IS both leukocytes (p≤0.05) NC (p&amp;lt;0.001), biologically older than patients These findings suggest need monitoring COVID-19 survivors, who represent majority general population.

Язык: Английский

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Comité de Gerontología. Abordaje clínico terapéutico del adulto mayor con diabetes mellitus

Revista de la Sociedad Argentina de Diabetes, Год журнала: 2024, Номер 58(1Sup), С. 28 - 32

Опубликована: Апрель 1, 2024

El desarrollo de la civilización se asocia con un incremento en edad población. Hoy Argentina el adulto mayor (AM: persona 65 años o más) varón tiene una expectativa vida 76 y mujer 80 años, lo que representa 15% del porcentaje población los grandes centros urbanos. Se estima AM diabetes mellitus (DM) es entre 20-30%. Esta patología, sus comorbilidades complicaciones (en especial cardiovasculares, infecciosas, cognitivas oncológicas) llaman a esfuerzo equipo salud y, especial, las personas dedicadas este grupo etario. Es importante enfoque multidisciplinario, adaptado circunstancias su situación sociocultural económica, orientando recursos prevención primaria, secundaria terciaria. Frente al cambio constante, actualmente requiere participación para brindar respuestas soluciones donde control metabólico, cardiovascular, cognitivo movilidad tiendan mantener independencia funcional fin priorizar seguridad técnicas diagnósticas terapéuticas marco diálogo acuerdos.

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Comparing real-world Type 2 diabetes management with the Francophone Diabetes Society’s recommendations: using comprehensive geriatric assessment-guided medication reviews of frail older adults living with comorbid diabetes and cancer

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Purpose: Substantial clinical heterogeneity in older adults with diabetes makes therapeutic management challenging. This study compared real-world type 2 of outpatients who had comorbid cancer published guidelines order to identify the circumstances which antidiabetic treatment de-intensification might be appropriate. Methods: We retrospectively analysed data from comprehensive geriatric assessment-guided medication reviews all referred our oncology day hospital unit 2022-2023. Results: Of 738 a review, 190 diabetes; mean age was 79.5 ± 5.6 years. Despite high prevalence frailties and syndromes observed, HbA1c level low (6.89% 1.03%). Two-thirds (63.5%) participants an outside recommended individual target range. these, 80% below range, suggesting overtreatment. Sulfonylureas glinides accounted for 18.4% 11.6% prescriptions, respectively. A total 170 diabetes-related issues were identified 67.9% patients. Having range (p < 0.001) receiving at least three prescribed drugs (p< 0.05) both significantly associated having one issue. Conclusion: Our revealed overly aggressive glycaemic control this frail population patients highlights poor adherence official guidelines. Geriatrician-pharmacist collaborations could provide more understanding patients’ health status functional category profiles improve diabetes.

Язык: Английский

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