Heliyon,
Год журнала:
2025,
Номер
11(2), С. e41836 - e41836
Опубликована: Янв. 1, 2025
The
immune
response
is
an
intricate
system
that
involves
the
complex
connection
of
cellular
and
molecular
components,
each
with
distinct
functional
specialisations.
It
has
a
capacity
to
adjust
mould
in
accordance
specific
stimuli,
influenced
by
both
genetic
environmental
factors.
presence
diversity,
particularly
across
different
ethnic
racial
groups,
significantly
contributes
impact
incidence
diseases,
disease
susceptibility,
autoimmune
disorders,
cancer
risks
regions
certain
populations.
Environmental
factors,
including
geography
socioeconomic
status,
further
modulate
variety
responses.
These,
turn,
affect
susceptibility
infectious
diseases
development
disorders.
Despite
complexity
relationship,
there
remains
gap
understanding
specificity
indices
races,
reference
ranges
among
populations,
highlighting
need
for
deeper
diversity
personalized
approaches
diagnostics
therapeutics.
This
review
systematically
organizes
these
findings,
goal
emphasizing
potential
targeted
interventions
address
health
disparities
advance
translational
research,
enabling
more
comprehensive
strategy.
approach
promises
significant
advancements
identifying
immunological
conditions,
focusing
on
interventions,
through
International Journal of Medical Sciences,
Год журнала:
2019,
Номер
16(11), С. 1424 - 1429
Опубликована: Янв. 1, 2019
Down-regulation
of
Growth
arrest-specific
5
(GAS5)
is
correlated
with
enhanced
cell
proliferation
and
poorer
prognosis
prostate
cancer.
We
aimed
to
investigate
the
effect
variant
rs145204276
GAS5
on
cancer
susceptibility
clinicopathologic
characteristics.
In
this
study,
579
patients
who
underwent
robot-assisted
radical
prostatectomy
healthy
controls
were
included.
The
frequency
allele
del
compared
between
evaluate
impact
tumor
correlation
clinicopathological
variables.
results
shown
that
carries
genotype
ins/del
or
del/del
at
SNP
showed
decreased
risk
pathological
lymph
node
metastasis
disease
(OR=0.545,
p=0.043)
seminal
vesicle
invasion
(OR=0.632,
p=0.022)
comparing
ins/ins.
subgroup
analysis
age,
more
significant
reduction
effects
noted
over
(OR=0.426,
p=0.032)
lymphovascular
(OR=0.521,
p=0.025).
conclusion,
polymorphic
can
predict
metastasis.
This
first
study
report
gene
polymorphism
prognosis.
Heliyon,
Год журнала:
2025,
Номер
11(2), С. e41836 - e41836
Опубликована: Янв. 1, 2025
The
immune
response
is
an
intricate
system
that
involves
the
complex
connection
of
cellular
and
molecular
components,
each
with
distinct
functional
specialisations.
It
has
a
capacity
to
adjust
mould
in
accordance
specific
stimuli,
influenced
by
both
genetic
environmental
factors.
presence
diversity,
particularly
across
different
ethnic
racial
groups,
significantly
contributes
impact
incidence
diseases,
disease
susceptibility,
autoimmune
disorders,
cancer
risks
regions
certain
populations.
Environmental
factors,
including
geography
socioeconomic
status,
further
modulate
variety
responses.
These,
turn,
affect
susceptibility
infectious
diseases
development
disorders.
Despite
complexity
relationship,
there
remains
gap
understanding
specificity
indices
races,
reference
ranges
among
populations,
highlighting
need
for
deeper
diversity
personalized
approaches
diagnostics
therapeutics.
This
review
systematically
organizes
these
findings,
goal
emphasizing
potential
targeted
interventions
address
health
disparities
advance
translational
research,
enabling
more
comprehensive
strategy.
approach
promises
significant
advancements
identifying
immunological
conditions,
focusing
on
interventions,
through
