Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

ACS Pharmacology & Translational Science, Год журнала: 2023, Номер 6(4), С. 447 - 518

Опубликована: Март 6, 2023

Turmeric (

Язык: Английский

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Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 147, С. 112658 - 112658

Опубликована: Янв. 20, 2022

The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more than three hundred million individuals and resulted in five deaths worldwide. ongoing pandemic underscored urgent need for effective preventive therapeutic measures to develop anti-viral therapy. natural compounds possess various pharmaceutical properties are reported as anti-virals. interest an drug against novel severe acute respiratory syndrome (SARS-CoV-2) from increased globally. Here, we investigated potential selected promising products. Sources data this paper current literature published context uses phytoconstituents their mechanism action reputed peer-reviewed journals. An extensive survey was done were critically analyzed get deeper insights into a few important phytoconstituents. consumption products such thymoquinone, quercetin, caffeic acid, ursolic ellagic vanillin, thymol, rosmarinic acid could improve our immune response thus possesses excellent potential. This review focuses on functions phytoconstituent alkaloids implications SARS-CoV-2. Our comprehensive analysis provides mechanistic restrain viral infection provide better solution through natural, therapeutically active agents.

Язык: Английский

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In vitro potential antiviral SARS-CoV-19- activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa

Bioorganic Chemistry, Год журнала: 2022, Номер 120, С. 105587 - 105587

Опубликована: Янв. 1, 2022

Язык: Английский

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Combination Anticancer Therapies Using Selected Phytochemicals

Molecules, Год журнала: 2022, Номер 27(17), С. 5452 - 5452

Опубликована: Авг. 25, 2022

Cancer is still one of the most widespread diseases globally, it considered a vital health challenge worldwide and main barriers to long life expectancy. Due potential toxicity lack selectivity conventional chemotherapeutic agents, discovering alternative treatments top priority. Plant-derived natural products have high in cancer treatment due their multiple mechanisms action, diversity structure, availability nature, relatively low toxicity. In this review, anticancer common phytochemicals were analyzed. Furthermore, detailed discussion effect combinations consisting product or with drugs was provided. This review should provide strong platform for researchers clinicians improve basic clinical research development medicines.

Язык: Английский

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Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies

Cells, Год журнала: 2022, Номер 11(2), С. 253 - 253

Опубликована: Янв. 12, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes disease 2019 (COVID-19). This illness was declared pandemic by the world health organization (WHO) in March 2020, just few weeks after being described for first time. Since then, global research effort has considerably increased humanity’s knowledge about both viruses and disease. It also spawned several vaccines have proven to be key tools attenuating spread of severity COVID-19. However, with vaccine-related skepticism on rise, as well breakthrough infections vaccinated population threat complete immune escape variant, alternative strategies fight against SARS-CoV-2 are urgently required. Calcium signals long been known play an essential role infection diverse thus constitute promising avenue further therapeutic strategies. In this review, we introduce pivotal calcium signaling viral cascades. Based this, discuss prospective calcium-related treatment targets cure COVID-19 exploit dependence signals.

Язык: Английский

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Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction

Antioxidants, Год журнала: 2023, Номер 12(3), С. 607 - 607

Опубликована: Март 1, 2023

Black cumin seeds and seed oil have long been used in traditional foods medicine South Asian, Middle Eastern Mediterranean countries are valuable flavor ingredients. An important ingredient of black is the small molecule thymoquinone (TQ), which manifests low toxicity potential therapeutic activity against a wide number diseases including diabetes, cancer neurodegenerative disorders. In this study, antioxidant activities oil, TQ related found cumin, thymohydroquinone (THQ), were measured using direct electrochemical method to experimentally evaluate their superoxide scavenging action. showed good ability, while THQ did not. Density Functional Theory (DFT) computational methods applied arrive at chemical mechanism describing these results, confirmed experimental Rotating Ring Disk Electrode (RRDE) findings that oxidation O2 by feasible, contrast with THQ, does not scavenge superoxide. Additionally, thorough inquiry into unusual cyclic voltammetry pattern exhibited was studied associated formation 1:1 TQ-superoxide radical species, [TQ-O2]-•. DFT calculations reveal species be involved π-π reactivity The crystal structures analyzed, data presence stacking intermolecular interactions can All three essential for us explains activity, incorporates features structure correlates activity.

Язык: Английский

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A Comprehensive Review of the Antioxidant, Antimicrobial, and Therapeutic Efficacies of Black Cumin (Nigella sativa L.) Seed Oil and Its Thymoquinone

Journal of Medicinal Food, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Black cumin (Nigella sativa L.) (family Ranunculaceae) is a largely utilized therapeutic herb worldwide. This comprehensive review discusses the pharmacological benefits of black seed oil, focusing on its bioactive component thymoquinone (TQ). The structured as follows: First, we examine antimicrobial properties followed by an analysis antioxidant capabilities. Finally, explore potential, particularly in neurodegenerative diseases and COVID-19. Phytochemicals from N. have exhibited potential for developing novel preventive strategies against jaundice, gastrointestinal disorders, skin diseases, anorexia, conjunctivitis, dyspepsia, intrinsic hemorrhage, amenorrhea, paralysis, rheumatism, diabetes, hypertension, fever, influenza, eczema, asthma, cough, bronchitis, headache. broader spectrum application essential bioactives certainly enhanced commercial value this oil. TQ, major constituent has numerous beneficial properties. Researchers extensively studied oil component, TQ. These studies revealed wide range properties, including anticancer, immunomodulatory, analgesic, antimicrobial, antidiabetic, anti-inflammatory effects. Additionally, TQ shown neuroprotective, spasmolytic, bronchodilatory, hepatoprotective, renoprotective, gastroprotective, activities.

Язык: Английский

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A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed (Nigella sativa)

Foods, Год журнала: 2022, Номер 11(18), С. 2826 - 2826

Опубликована: Сен. 13, 2022

The current review investigates the effects of black seed (

Язык: Английский

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A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study

Toxicology Reports, Год журнала: 2022, Номер 9, С. 999 - 1007

Опубликована: Янв. 1, 2022

Black cumin or black seed (Nigella sativa L.) is a popular medicinal herb and culinary spice belonging to Ranunculacea family. Thymoquinone (TQ) the major active phytoconstituent in abundant volatile oil fraction. Though containing low TQ content (less than 1%) has been clinically investigated, clinical efficacy safety data of TQ-rich limited. A recent study with formulation 5% (BCO-5) exhibited significant alleviate sleep disorders stress. So, present phase 1 randomized, double-blinded, placebo-controlled trial evaluated BCO-5 at dose 200 mg/adult/day for 90 days on healthy subjects (n = 70). Both biochemical hematological parameters were analysed along adverse events side effects establish BCO-5. The reported neither serious nor any alterations parameters. absence changes related liver function (ALT, AST, ALP), renal (serum creatinine urea) also observed. However, analysis lipid profile showed (P < 0.05) reduction total cholesterol, LDL, VLDL triglycerides, but within normal range. In conclusion, safe human consumption may be various health beneficial pharmacological activities where shown have positive effects.

Язык: Английский

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Plant-Derived Terpenoids: A Promising Tool in the Fight against Melanoma

Cancers, Год журнала: 2022, Номер 14(3), С. 502 - 502

Опубликована: Янв. 20, 2022

Melanoma is responsible for the highest number of skin cancer-caused deaths worldwide. Despite numerous melanoma-treating options, fight against it remains challenging, mainly due to its great heterogeneity and plasticity, as well high toxicity standard drugs. Plant-derived terpenoids are a group plant defense molecules that have been proven effective in killing many different types cancer cells, both vitro experiments vivo models. In this review, we focus on recent results search with anti-melanoma activity. We also report synergistic action combining other plant-derived substances, MAP kinase inhibitors, or radiation. Additionally, present examples terpenoid-loaded nanoparticle carriers agents increased permeation through tissue.

Язык: Английский

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