Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(3), С. 331 - 331
Опубликована: Март 8, 2024
Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, lipid-lowering effects, in addition thermogenic capacity. While intake dietary sources such as curry may be sufficient affect intestinal microbiome thus act indirectly, intact curcumin body too low (<1 microM) not signaling gene expression, observed vitro with cultured cells (10–20 microM). Several strategies can envisioned increase levels body, decreasing metabolism or absorption through formation nanoparticles. However, since high could also lead undesired regulatory effects on cellular studies need carefully monitored. Here, we review bioavailability what extent using nanoformulations bioactivity metabolites. This enhancement potentially amplify disease-preventing curcumin, often by leveraging robust antioxidant properties.
Язык: Английский
Процитировано
37
ACS Omega, Год журнала: 2024, Номер 9(9), С. 10030 - 10048
Опубликована: Фев. 22, 2024
Skin cancer (SC) poses a global threat to the healthcare system and is expected increase significantly over next two decades if not diagnosed at an early stage. Early diagnosis crucial for successful treatment, as disease becomes more challenging cure it progresses. However, identifying new drugs, achieving clinical success, overcoming drug resistance remain significant challenges. To overcome these obstacles provide effective understand causes of skin cancer, how cells grow divide, factors that affect cell growth, occurs. In this review, we have explained various therapeutic approaches SC treatment via ligands, targeted photosensitizers, natural synthetic drugs SC, epigenetic approach management melanoma, photodynamic therapy, therapy BRAF-mutated melanoma. This article also provides detailed summary are in managing melanoma reducing occurrence stages focuses on current status future prospects therapies available cancer.
Язык: Английский
Процитировано
16
Food Chemistry Advances, Год журнала: 2023, Номер 3, С. 100488 - 100488
Опубликована: Окт. 18, 2023
Recently, significant attention has been paid to the biologically active substances in plants that aid preventing, treating or delaying diseases brought on by inflammatory and oxidative processes. There is scientific evidence support use of plant extracts traditional medicines treat bacterial, protozoal, helminthic illnesses. From leaf Vernonia amygdalina also, phytochemicals have identified extracted, including alkaloids, tannins, steroids, cyanogenic glycosides, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, oxalate saponins. This article provides a comprehensive overview bioactive components bitter how they contribute its medicinal properties. Its health benefits; ability lower cholesterol levels, it's anticancer antioxidant properties as well potential natural remedy for diabetes are also discussed. Conclusively, underscores significance drinking juice effects it wellness.
Язык: Английский
Процитировано
32
Vegetos, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
10
Pharmaceuticals, Год журнала: 2024, Номер 17(6), С. 670 - 670
Опубликована: Май 22, 2024
Given the ongoing rise in occurrence of allergic disorders, alterations dietary patterns have been proposed as a possible factor contributing to emergence and progression these conditions. Currently, there is significant focus on development therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols plant metabolites intensively researched due their well-documented anti-inflammatory, antioxidant, immunomodulatory characteristics, making them one most prominent bioactive chemicals. This study seeks discuss in-depth mechanisms by which molecules may exert anti-allergic effects, namely through capacity diminish allergenicity proteins, modulate immune responses, modify composition gut microbiota. However, further investigation required fully understand effects. paper examines existing evidence from experimental clinical studies supports idea different polyphenols, such catechins, resveratrol, curcumin, quercetin, others, can reduce inflammation, relieve symptoms food allergy, asthma, atopic dermatitis, rhinitis, prevent response. In summary, possess properties be utilized for developing both preventative therapeutic strategies targeting The also discusses constraints investigating broad usage well potential avenues future research.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 12587 - 12587
Опубликована: Авг. 9, 2023
Due to the progressive ageing of human population, number cancer cases is increasing. For this reason, there an urgent need for new treatments that can prolong lives patients or ensure them a good quality life. Although significant progress has been made in treatment recent years and survival rate increasing, limitations use conventional therapies include frequent occurrence side effects development resistance chemotherapeutic agents. These are prompting researchers investigate whether combining natural agents with drugs could have positive therapeutic effect treatment. Several bioactive compounds, especially polyphenols, shown be effective against progression do not exert toxic on healthy tissues. Many studies investigated possibility polyphenols as novel anticancer strategy. Indeed, combination often synergistic benefits increase drug efficacy reduce adverse effects. In review, we provide overview describing curcumin, polyphenol extensive cytotoxic functions cells, including combined particular, described results preclinical clinical exploring pleiotropic curcumin standard potential consider it promising tool therapy.
Язык: Английский
Процитировано
17
Food Hydrocolloids, Год журнала: 2023, Номер 147, С. 109422 - 109422
Опубликована: Окт. 16, 2023
Язык: Английский
Процитировано
17
Archives of Pharmacology and Therapeutics, Год журнала: 2023, Номер 5(1), С. 53 - 66
Опубликована: Ноя. 4, 2023
Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes stomach and associated range gastrointestinal diseases, including chronic gastritis, peptic ulcers, gastric cancer. current standard care for H. involves combination antibiotics proton pump inhibitors (PPIs), but widespread use has led to development antibiotic-resistant strains pylori, making treatment more difficult. Recent advances in diagnostic strategies include non-invasive tests serological biomarkers. While PPIs remains primary approach, there growing interest alternative therapies, botanical extracts, natural products, traditional medicines. research also explored potential probiotics, phage therapy, novel antibiotics, such as rifabutin furazolidone, infection. studies have artificial intelligence (AI) diagnosis management AI-assisted screening methods identified extracts products anti-H. activity, providing new avenues therapeutic development. Additionally, AI can improve accuracy outcomes. Although these approaches show promise, further needed confirm their efficacy, safety, optimal dosing. Novel therapies therapy may provide treatments help overcome antimicrobial resistance.
Язык: Английский
Процитировано
17
Beilstein Journal of Nanotechnology, Год журнала: 2024, Номер 15, С. 37 - 50
Опубликована: Янв. 4, 2024
Leishmaniasis is a neglected tropical disease that has affected more than 350 million people worldwide and can manifest itself in three different forms: cutaneous, mucocutaneous, or visceral. Furthermore, the current treatment options have drawbacks which compromise efficacy patient compliance. To face this global health concern, new alternatives for of leishmaniasis been explored. Curcumin, polyphenol obtained from rhizome turmeric, exhibits leishmanicidal activity against species Leishmania spp . Although its mechanism action not yet fully elucidated, potential may be associated with antioxidant anti-inflammatory properties. However, it limitations clinical use. Conversely, nanotechnology used as tool solving biopharmaceutical challenges drugs, such curcumin. From drug delivery standpoint, nanocarriers (1–1000 nm) improve stability, increase solubility, promote intracellular delivery, biological activity. Thus, review offers deep look into curcumin-loaded intended leishmaniasis.
Язык: Английский
Процитировано
7
Pharmacological Research, Год журнала: 2024, Номер 203, С. 107167 - 107167
Опубликована: Апрель 9, 2024
Cancer has become a burgeoning global healthcare concern marked by its exponential growth and significant economic ramifications. Though advancements in the treatment modalities have increased overall survival quality of life, there are no definite treatments for advanced stages this malady. Hence, understanding diseases etiologies underlying molecular complexities, will usher development innovative therapeutics. Recently, YAP/TAZ transcriptional regulation been immense interest due to their role development, tissue homeostasis oncogenic transformations. axis functions as coactivators within Hippo signaling cascade, exerting pivotal influence on processes such proliferation, regeneration, renewal. In cancer, YAP is overexpressed multiple tumor types associated with cancer stem cell attributes, chemoresistance, metastasis. Activation mirrors cellular "social" behavior, encompassing factors adhesion mechanical signals transmitted from structure surrounding extracellular matrix. Therefore, it presents vulnerability clogs tumors that could provide wide window therapeutic effectiveness. Natural compounds utilized extensively successful interventions management diverse chronic illnesses, including cancer. Owing capacity genes pathways, natural exhibit potential either adjuvant therapy or combination conventional options. review, we delineate nexus axis, present an alternate strategy target
Язык: Английский
Процитировано
7