International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 95 - 95
Опубликована: Дек. 21, 2022
Inflammation
is
an
integral
part
of
autoimmune
diseases,
which
are
caused
by
dysregulation
the
immune
system.
This
involves
imbalance
between
pro-inflammatory
versus
anti-inflammatory
mediators.
These
mediators
include
various
cytokines
and
chemokines;
defined
subsets
T
helper/T
regulatory
cells,
M1/M2
macrophages,
activating/tolerogenic
dendritic
antibody-producing/regulatory
B
cells.
Despite
availability
many
anti-inflammatory/immunomodulatory
drugs,
severe
adverse
reactions
associated
with
their
long-term
use
often
high
costs
impediments
in
effectively
controlling
disease
process.
Accordingly,
suitable
alternatives
being
sought
for
these
conventional
drugs.
Natural
products
offer
promising
adjuncts/alternatives
this
regard.
The
specific
compounds
isolated
from
dietary/medicinal
plant
extracts
have
permitted
rigorous
studies
on
disease-modulating
activities
mechanisms
involved
therein.
Here,
we
describe
basic
characteristics,
action,
preventive/therapeutic
applications
5
well-characterized
natural
product
(Resveratrol,
Curcumin,
Boswellic
acids,
Epigallocatechin-3-gallate,
Triptolide).
been
tested
extensively
animal
models
autoimmunity
as
well
limited
clinical
trials
patients
having
corresponding
diseases.
We
focused
our
description
predominantly
cell-mediated
such
rheumatoid
arthritis,
multiple
sclerosis,
Type
1
diabetes,
ulcerative
colitis,
psoriasis.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3755 - 3755
Опубликована: Фев. 13, 2023
As
the
greatest
defense
organ
of
body,
skin
is
exposed
to
endogenous
and
external
stressors
that
produce
reactive
oxygen
species
(ROS).
When
antioxidant
system
body
fails
eliminate
ROS,
oxidative
stress
initiated,
which
results
in
cellular
senescence,
inflammation,
cancer.
Two
main
possible
mechanisms
underlie
stress-induced
One
mechanism
ROS
directly
degrade
biological
macromolecules,
including
proteins,
DNA,
lipids,
are
essential
for
cell
metabolism,
survival,
genetics.
Another
one
mediate
signaling
pathways,
such
as
MAPK,
JAK/STAT,
PI3K/AKT/mTOR,
NF-κB,
Nrf2,
SIRT1/FOXO,
affecting
cytokine
release
enzyme
expression.
natural
antioxidants,
plant
polyphenols
safe
exhibit
a
therapeutic
potential.
We
here
discuss
detail
potential
selected
polyphenolic
compounds
outline
relevant
molecular
targets.
Polyphenols
study
according
their
structural
classification
include
curcumin,
catechins,
resveratrol,
quercetin,
ellagic
acid,
procyanidins.
Finally,
latest
delivery
(taking
curcumin
an
example)
current
status
clinical
research
summarized,
providing
theoretical
foundation
future
generation
new
pharmaceuticals
cosmetics.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 229 - 229
Опубликована: Янв. 10, 2023
Curcumin
(CUR)
is
a
polyphenol
extracted
from
the
rhizome
of
Curcuma
longa
that
possesses
potent
anti-inflammatory
and
antioxidant
potential.
Despite
CUR’s
numerous
beneficial
effects
on
human
health,
it
has
limitations,
such
as
poor
absorption.
Nano-based
drug
delivery
systems
have
recently
been
applied
to
improve
solubility
bioavailability
potentialize
its
health
effects.
This
review
investigated
different
CUR-based
nanomedicines
inflammatory
immunomodulated
diseases.
PUBMED,
EMBASE,
COCHRANE,
GOOGLE
SCHOLAR
databases
were
searched,
Scale
for
Assessment
Narrative
Review
Articles
(SANRA)
was
used
quality
assessment
PRISMA
guidelines.
Overall,
66
studies
included
comprising
atherosclerosis,
rheumatoid
arthritis
(RA),
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
multiple
sclerosis
(MS),
Huntington’s
(HD),
bowel
diseases
(IBD),
psoriasis,
liver
fibrosis,
epilepsy,
COVID-19.
The
available
scientific
show
there
are
many
known
nanoformulations
with
curcumin.
They
can
be
found
in
nanosuspensions,
nanoparticles,
nanoemulsions,
solid
lipid
particles,
nanocapsules,
nanospheres,
liposomes.
These
formulations
CUR
effectively
adjuvants
several
immune-mediated
atheroma
plaque
formation,
RA,
dementia,
AD,
PD,
MS,
IBD,
COVID-19,
anti-fibrotic
fibrotic
disease.
Marine Drugs,
Год журнала:
2023,
Номер
21(6), С. 323 - 323
Опубликована: Май 26, 2023
Polyphenols
are
compounds
found
in
various
plants
and
foods,
known
for
their
antioxidant
anti-inflammatory
properties.
Recently,
researchers
have
been
exploring
the
therapeutic
potential
of
marine
polyphenols
other
minor
nutrients
that
algae,
fish
crustaceans.
These
unique
chemical
structures
exhibit
diverse
biological
properties,
including
anti-inflammatory,
antioxidant,
antimicrobial
antitumor
action.
Due
to
these
being
investigated
as
possible
agents
treatment
a
wide
variety
conditions,
such
cardiovascular
disease,
diabetes,
neurodegenerative
diseases
cancer.
This
review
focuses
on
applications
human
health,
also,
phenolic
classes,
extraction
methods,
purification
techniques
future
compounds.
Biomolecules,
Год журнала:
2023,
Номер
13(7), С. 1105 - 1105
Опубликована: Июль 12, 2023
Betulin
is
a
natural
triterpene,
usually
from
birch
bark,
known
for
its
potential
wound-healing
properties.
Despite
having
wide
range
of
pharmacological
targets,
no
studies
have
proposed
betulin
as
multitarget
compound.
has
protective
effects
against
cardiovascular
and
liver
diseases,
cancer,
diabetes,
oxidative
stress,
inflammation.
It
reduces
postprandial
hyperglycemia
by
inhibiting
α-amylase
α-glucosidase
activity,
combats
tumor
cells
inducing
apoptosis
metastatic
proteins,
modulates
chronic
inflammation
blocking
the
expression
proinflammatory
cytokines
via
modulation
NFκB
MAPKs
pathways.
Given
to
influence
diverse
biological
networks
with
high
target
specificity,
it
can
be
hypothesized
that
may
eventually
become
new
lead
drug
development
because
modify
variety
targets.
The
summarized
research
revealed
beneficial
in
various
diseases
attributed,
at
least
part,
anti-inflammatory
activity.
This
review
focuses
on
sources,
pharmacokinetics,
activity
betulin,
multi-target
signaling
pathways
such
MAPK,
NF-κB,
Nrf2,
which
are
important
regulators
response
stress
body.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Март 22, 2024
Abstract
Inflammation
has
accompanied
human
beings
since
the
emergence
of
wounds
and
infections.
In
past
decades,
numerous
efforts
have
been
undertaken
to
explore
potential
role
inflammation
in
cancer,
from
tumor
development,
invasion,
metastasis
resistance
tumors
treatment.
Inflammation-targeted
agents
not
only
demonstrate
suppress
cancer
but
also
improve
efficacy
other
therapeutic
modalities.
this
review,
we
describe
highly
dynamic
complex
inflammatory
microenvironment,
with
discussion
on
key
mediators
including
cells,
cytokines,
their
downstream
intracellular
pathways.
addition,
especially
address
development
highlight
action
mechanisms
inflammation-targeted
therapies
antitumor
response.
Finally,
summarize
results
both
preclinical
clinical
studies
up
date
illustrate
translation
therapies.
Nutrients,
Год журнала:
2024,
Номер
16(4), С. 507 - 507
Опубликована: Фев. 10, 2024
The
escalating
prevalence
of
metabolic
and
cardiometabolic
disorders,
often
characterized
by
oxidative
stress
chronic
inflammation,
poses
significant
health
challenges
globally.
As
the
traditional
therapeutic
approaches
may
sometimes
fall
short
in
managing
these
conditions,
attention
is
growing
toward
nutraceuticals
worldwide;
with
compounds
being
obtained
from
natural
sources
potential
beneficial
effects
shown
to
potentially
support
and,
some
cases,
replace
pharmacological
treatments,
especially
for
individuals
who
do
not
qualify
conventional
treatments.
This
review
delves
into
burgeoning
field
nutraceutical-based
modulation
as
a
promising
strategy
attenuating
inflammation
disorders.
Drawing
an
extensive
body
research,
showcases
various
nutraceutical
agents,
such
polyphenols,
omega-3
fatty
acids,
antioxidants,
which
exhibit
antioxidative
anti-inflammatory
properties.
All
can
be
classified
novel
drugs
that
are
capable
regulating
pathways
mitigate
oxidative-stress-
inflammation-associated
diseases.
By
exploring
mechanisms
through
interact
immune
responses,
this
highlights
their
restore
redox
balance
temper
inflammation.
Additionally,
prospects
interventions
discussed,
encompassing
bioavailability
enhancement,
personalized
treatment
approaches,
clinical
translation.
Through
comprehensive
analysis
latest
scientific
reports,
article
underscores
avenue
fight
complex
landscape
particularly
accentuating
impact
on
cardiovascular
health.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(6), С. 3169 - 3189
Опубликована: Апрель 14, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid‐beta
plaques
and
neurofibrillary
tangles,
leading
to
neuronal
loss.
Curcumin,
polyphenolic
compound
derived
from
Curcuma
longa
,
has
shown
potential
neuroprotective
effects
due
its
anti‐inflammatory
antioxidant
properties.
This
review
aims
synthesize
current
preclinical
data
on
anti‐neuroinflammatory
mechanisms
curcumin
in
context
AD,
addressing
pharmacokinetics,
bioavailability,
as
therapeutic
adjunct.
An
exhaustive
literature
search
was
conducted,
focusing
recent
studies
within
last
10
years
related
curcumin's
impact
neuroinflammation
role
AD.
The
methodology
included
sourcing
articles
specialized
databases
using
specific
medical
subject
headings
terms
ensure
precision
relevance.
Curcumin
demonstrates
significant
properties
modulating
neuroinflammatory
pathways,
scavenging
reactive
oxygen
species,
inhibiting
production
pro‐inflammatory
cytokines.
Despite
potential,
challenges
remain
regarding
limited
bioavailability
scarcity
comprehensive
human
clinical
trials.
emerges
promising
adjunct
AD
multimodal
benefits.
However,
further
research
required
overcome
establish
effective
dosing
regimens
subjects.
Developing
novel
delivery
systems
formulations
may
enhance
treatment.
Foods,
Год журнала:
2024,
Номер
13(11), С. 1774 - 1774
Опубликована: Июнь 5, 2024
Curcumin,
a
hydrophobic
polyphenol
extracted
from
the
rhizome
of
Curcuma
longa,
is
now
considered
candidate
drug
for
treatment
neurological
diseases,
including
Parkinson’s
Disease
(PD),
Alzheimer’s
(AD),
Huntington’s
(HD),
Multiple
Sclerosis
(MS),
Amyotrophic
Lateral
(ALS),
and
prion
disease,
due
to
its
potent
anti-inflammatory,
antioxidant
potential,
anticancerous,
immunomodulatory,
neuroprotective,
antiproliferative,
antibacterial
activities.
Traditionally,
curcumin
has
been
used
medicinal
dietary
purposes
in
Asia,
India,
China.
However,
low
water
solubility,
poor
stability
blood,
high
rate
metabolism,
limited
bioavailability,
little
capability
cross
blood–brain
barrier
(BBB)
have
clinical
application
curcumin,
despite
important
pharmacological
activities
this
drug.
A
variety
nanocarriers,
liposomes,
micelles,
dendrimers,
cubosome
nanoparticles,
polymer
solid
lipid
nanoparticles
developed
with
great
success
effectively
deliver
active
brain
cells.
Functionalization
on
surface
brain-specific
ligands
makes
them
target-specific,
which
should
significantly
improve
bioavailability
reduce
harmful
effects.
The
aim
review
summarize
studies
and/or
containing
most
common
neurodegenerative
highlighting
neuroprotective
potential
nutraceutical.
