Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1300 - 1300
Опубликована: Окт. 5, 2024
Background/Objectives:
Phloroglucinol
(PHL),
a
phenolic
compound
extracted
from
the
brown
alga
Rosenvingea
intricata,
exhibits
potent
antioxidant
and
anticancer
properties.
This
study
aims
to
extract,
purify,
characterize
PHL,
further
develop
functionalized
zinc
oxide
nanoparticles
(ZnO
NPs)
loaded
with
PHL
enhance
its
therapeutic
potential.
Methods:
was
using
acetone
purified
through
Sephadex
LH-20
column
chromatography,
yielding
highly
enriched
fraction
(F-3).
The
characterized
by
FTIR,
HPLC,
NMR,
LC-MS.
ZnO
NPs
were
synthesized,
PEGylated,
conjugated
forming
ZnO-PEG-PHL
NPs.
Their
characterization
included
DLS,
zeta
potential,
XRD,
SEM-EDAX,
encapsulation
efficiency
studies.
Antioxidant
assays
(DPPH,
FRAP,
ABTS,
RPA)
performed
in
vitro
cytotoxicity
on
A549
lung
cancer
cells
determined
evaluate
efficacy
of
PHL.
Results:
showed
high
content
(45.65
mg/g),
which
confirmed
spectral
analysis.
increased
size
32.36
nm
46.68
nm,
their
potential
shifting
−37.87
mV
−26.82
mV.
activity
superior
for
all
assays,
while
tests
an
IC50
40
µg/mL
compared
60
70
Apoptotic
studies
revealed
significant
cell
cycle
arrest
apoptosis
induction.
Conclusions:
synthesized
demonstrated
enhanced
properties,
making
them
promising
candidates
therapy
applications.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 692 - 692
Опубликована: Май 27, 2024
There
are
a
wide
variety
of
phytochemicals
collectively
known
as
polyphenols.
Their
structural
diversity
results
in
broad
range
characteristics
and
biological
effects.
Polyphenols
can
be
found
foods
drinks,
including
fruits,
cereals,
tea,
coffee.
Studies
both
vitro
vivo,
well
clinical
trials,
have
shown
that
they
possess
potent
antioxidant
activities,
numerous
therapeutic
effects,
health
advantages.
Dietary
polyphenols
demonstrated
the
potential
to
prevent
many
problems,
obesity,
atherosclerosis,
high
blood
sugar,
diabetes,
hypertension,
cancer,
neurological
diseases.
In
this
paper,
protective
effects
mechanisms
behind
them
investigated
detail,
citing
most
recent
available
literature.
This
review
aims
provide
comprehensive
overview
current
knowledge
on
role
preventing
managing
chronic
The
cited
publications
derived
from
vitro,
human-based
studies
trials.
A
more
complete
understanding
these
naturally
occurring
metabolites
will
pave
way
for
development
novel
polyphenol-rich
diet
drug
programs.
This,
turn,
provides
further
evidence
their
benefits.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 797 - 797
Опубликована: Янв. 8, 2024
Seaweed,
a
miscellaneous
group
of
marine
algae,
has
long
been
recognized
for
its
rich
nutritional
composition
and
bioactive
compounds,
being
considered
nutraceutical
ingredient.
This
revision
delves
into
the
promising
role
seaweed-derived
nutrients
as
beneficial
resource
drug
discovery
innovative
product
development.
Seaweeds
are
abundant
sources
essential
vitamins,
minerals,
polysaccharides,
polyphenols,
unique
secondary
metabolites,
which
reveal
wide
range
biological
activities.
These
compounds
possess
potential
therapeutic
properties,
making
them
intriguing
candidates
leads
in
various
medical
applications
pharmaceutical
It
explores
their
pharmacological
including
antioxidant,
anti-inflammatory,
antimicrobial,
anticancer
activities,
shedding
light
on
agents.
Moreover,
manuscript
provides
insights
development
formulation
strategies
delivery
systems
to
enhance
bioavailability
stability
compounds.
The
also
discusses
challenges
opportunities
associated
with
integration
seaweed-based
industries.
Regulatory
considerations,
sustainability,
scalability
sustainable
seaweed
sourcing
cultivation
methods
addressed,
emphasizing
need
holistic
approach
harnessing
seaweed's
potential.
underscores
immense
valuable
reservoir
By
bridging
gap
between
biology,
pharmacology,
formulation,
this
research
contributes
critical
advancement
solutions
sectors.
Nutrients,
Год журнала:
2024,
Номер
16(8), С. 1123 - 1123
Опубликована: Апрель 10, 2024
This
review
delves
into
the
burgeoning
field
of
seaweed
proteins
as
promising
alternative
sources
protein.
With
global
demand
escalating
and
concerns
over
traditional
protein
sources'
sustainability
ethics,
emerges
a
viable
solution,
offering
high
content
minimal
environmental
impacts.
Exploring
nutritional
composition,
extraction
methods,
functional
properties,
potential
health
benefits
proteins,
this
provides
comprehensive
understanding.
Seaweed
contains
essential
amino
acids,
vitamins,
minerals,
antioxidants.
Its
ranges
from
11%
to
32%
dry
weight,
making
it
valuable
for
diverse
dietary
preferences,
including
vegetarian
vegan
diets.
Furthermore,
underscores
advantages
production
compared
sources.
cultivation
requires
resources,
mitigating
issues
like
ocean
acidification.
As
specific
types,
methodologies,
highlights
versatility
in
various
food
products,
plant-based
meats,
dairy
alternatives,
supplements.
Additionally,
discusses
associated
with
such
their
unique
acid
profile
bioactive
compounds.
Overall,
aims
provide
insights
proteins'
applications
role
addressing
needs
sustainably.
The
environmental
impact
of
drug
manufacturing
raises
concerns
about
sustainability
in
healthcare.
To
address
this,
exploring
alternative
approaches
to
production
is
crucial.
This
review
focuses
on
seaweed
as
a
sustainable
resource
for
greening
processes.
Seaweed
offers
advantages
such
renewability,
abundance,
and
positive
footprint.
begins
by
providing
an
overview
practices
the
challenges
faced
achieving
sustainability.
It
then
discusses
resource,
including
cultivation
techniques
benefits.
has
various
applications
manufacturing,
extracting
purifying
bioactive
compounds
with
potential
therapeutic
properties.
Seaweed’s
role
developing
green
technologies,
seaweed-based
excipients,
biodegradable
packaging
materials,
source
energy
processes,
highlighted.
economic
implications
incorporating
solutions
are
discussed,
emphasizing
reduced
carbon
footprint
cost-effectiveness.
Regulatory
industrial
perspectives
addressed,
examining
challenges,
opportunities
implementing
manufacturing.
Collaboration
between
academia,
industry,
regulatory
bodies
crucial
successful
integration.
presents
future
directions
opportunities,
emerging
trends
innovations
areas
further
research,
policy
development,
industry
engagement
recommendations.
Incorporating
into
facilitates
reduction
impact,
promotes
efficiency,
contributes
showcases
means
foster
greener
addressing
concerns,
promoting
Algal Research,
Год журнала:
2024,
Номер
78, С. 103407 - 103407
Опубликована: Янв. 29, 2024
The
term
“non-indigenous
species”
(NIS)
describes
creatures
that
have
colonized
previously
unoccupied
parts
of
the
globe.
They
enormous
ecological
and
economic
problems
everywhere
because
their
expanding
presence.
success
biological
invaders
in
this
setting
has
recently
been
a
hot
topic.
Of
thousands
marine
NIS
introduced
all
over
world,
seaweeds
(marine
macroalgae)
are
significant
part.
Global
investigations
conducted
past
ten
years
identified
>277
species
invasive
seaweeds.
More
than
100
seaweed
found
Europe,
northeastern
Atlantic
is
especially
renowned
for
harboring
large
number
these
species.
main
can
currently
be
waters
(Atlantic
Mediterranean)
Iberian
Peninsula
(including
respective
archipelagos)
will
topic
revision,
which
examine
processes
invasion
from
introduction
stage
vectors
to
success.
In
order
demonstrate
how
species,
endangering
ecosystem,
an
excellent
environmental
resource
bioactive
compounds
with
high
industrial
potential
socioeconomic
revenue,
management
as
well
uses
biofertilizers,
bioactivities,
feed,
food
were
also
addressed.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 915 - 915
Опубликована: Янв. 22, 2025
Polyphenols
are
micronutrients
found
in
fruits,
vegetables,
tea,
coffee,
cocoa,
medicinal
herbs,
fish,
crustaceans,
and
algae.
They
can
also
be
synthesized
using
recombinant
microorganisms.
Interest
plant-derived
natural
compounds
has
grown
due
to
their
potential
therapeutic
effects
with
minimal
side
effects.
This
is
particularly
important
as
the
aging
population
faces
increasing
rates
of
chronic
diseases
such
cancer,
diabetes,
arthritis,
cardiovascular,
neurological
disorders.
Studies
have
highlighted
polyphenols’
capacity
reduce
risk
factors
linked
onset
illnesses.
narrative
review
discusses
polyphenol
families
metabolism,
cardioprotective
polyphenols
evidenced
from
vitro
studies,
well
vivo
on
different
animal
models
cardiac
disease.
study
explores
molecular
mechanisms
underlying
these
benefits.
Current
research
suggests
that
may
protect
against
ischemia,
hypertension,
hypertrophy,
heart
failure,
myocardial
injury
through
complex
mechanisms,
including
epigenetic
genomic
modulation.
However,
further
studies
under
nutritionally
physiologically
relevant
conditions,
untargeted
multigenomic
approaches,
needed
more
comprehensively
elucidate
firmly
prove
polyphenols.
Marine Drugs,
Год журнала:
2024,
Номер
22(5), С. 201 - 201
Опубликована: Апрель 27, 2024
Marine
molluscs
are
of
enormous
scientific
interest
due
to
their
astonishing
diversity
in
terms
size,
shape,
habitat,
behaviour,
and
ecological
roles.
The
phylum
Mollusca
is
the
second
most
common
animal
phylum,
with
100,000
200,000
species,
marine
among
notable
class
organisms.
This
work
aimed
show
importance
as
a
potential
source
nutraceuticals
well
natural
medicinal
drugs.
In
this
review,
main
classes
molluscs,
chemical
ecology,
different
techniques
used
for
extraction
bioactive
compounds
have
been
presented.
We
pointed
out
nutraceutical
such
proteins,
peptides,
polysaccharides,
lipids,
polyphenolic
pigments,
enzymes,
minerals,
vitamins.
Their
pharmacological
activities
include
antimicrobial,
anticancer,
antioxidant,
anti-inflammatory,
analgesic
activities.
Moreover,
certain
like
abalones
mussels
contain
unique
applications,
ranging
from
wound
healing
anti-cancer
effects.
Understanding
nutritional
therapeutic
value
highlights
significance
both
pharmaceutical
dietary
realms,
paving
way
further
research
utilization
human
health.
