International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1455 - 1455
Опубликована: Янв. 11, 2023
Polycyclic
aromatic
hydrocarbons
(PAHs)
are
one
of
the
most
prevalent
classes
environmental
pollutants.
Some
evidence
shows
that
PAHs
could
be
involved
in
human
obesity.
However,
little
is
known
about
distribution
patterns
adipose
tissue
(AT)
and
role
on
adipogenesis/lipogenesis.
The
aims
this
pilot
study
were
to
determine
concentrations
16
defined
as
high-priority
pollutants
plasma
French
Polish
bariatric
patients,
well
their
correlation
with
body
mass
index
(BMI),
AT
adipokines
expression
levels.
We
finally
investigated
naphthalene
cell
proliferation,
viability,
differentiation
3T3-L1
preadipocytes.
concentration
was
similar
three
types
it
significantly
higher
compared
plasma,
suggesting
bioaccumulation.
patients
had
PAH
levels
than
ones.
Only
positively
correlated
BMI
serum
or
chemerin,
adiponectin
resistin
expression,
but
not
who
BMIs.
Moreover,
exposure
increased
proliferation
preadipocytes
lipogenesis,
genes
adipogenesis
after
differentiation.
Taken
together,
more
particularly
an
obesogenic
molecule
increase
risk
Molecules,
Год журнала:
2023,
Номер
28(15), С. 5623 - 5623
Опубликована: Июль 25, 2023
This
review
describes
the
various
innovative
approaches
implemented
for
naringin
extraction
as
well
recent
developments
in
field.
Naringin
was
assessed
terms
of
its
structure,
chemical
composition,
and
potential
food
sources.
How
works
pharmacologically
discussed,
including
an
anti-diabetic,
anti-inflammatory,
hepatoprotective
substance.
Citrus
flavonoids
are
crucial
herbal
additives
that
have
a
huge
spectrum
organic
activities.
is
nutritional
flavanone
glycoside
has
been
shown
to
be
effective
treatment
few
chronic
disorders
associated
with
ageing.
fruits
contain
common
flavone
specific
pharmacological
biological
properties.
Naringin,
range
intriguing
characteristics,
abundant
citrus
fruits.
variety
biological,
medicinal,
effects.
hydrolyzed
into
rhamnose
prunin
by
naringinase,
which
also
possesses
l-rhamnosidase
activity.
D-glucosidase
subsequently
catalyzes
hydrolysis
glucose
naringenin.
known
having
antioxidant,
tumor-fighting
Numerous
test
animals
cell
lines
used
correlate
exposure
asthma,
hyperlipidemia,
diabetes,
cancer,
hyperthyroidism,
osteoporosis.
study
focused
on
many
documented
actions
in-vitro
in-vivo
experimental
preclinical
investigations,
prospective
therapeutic
advantages,
utilizing
information
presently
accessible
literature.
In
addition
pharmacokinetic
naringin’s
distribution,
different
methods,
use
cosmetic,
food,
pharmaceutical,
animal
feed
sectors
were
discussed.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 16, 2023
Brown
adipose
tissue
(BAT),
a
thermoregulatory
organ
known
to
promote
energy
expenditure,
has
been
extensively
studied
as
potential
avenue
combat
obesity.
Although
BAT
is
the
opposite
of
white
(WAT)
which
responsible
for
storage,
shares
thermogenic
capacity
with
beige
that
emerges
from
WAT
depots.
This
unsurprising
both
and
display
huge
difference
in
terms
their
secretory
profile
physiological
role.
In
obesity,
content
declines
these
tissues
acquire
characteristics
via
process
called
“whitening”.
rarely
explored
its
implication
whether
it
contributes
or
exacerbates
Emerging
research
demonstrated
BAT/beige
whitening
sophisticated
metabolic
complication
obesity
linked
multiple
factors.
The
current
review
provides
clarification
on
influence
various
factors
such
diet,
age,
genetics,
thermoneutrality,
chemical
exposure
whitening.
Moreover,
defects
mechanisms
underpin
are
described.
Notably,
can
be
marked
by
accumulation
large
unilocular
lipid
droplets,
mitochondrial
degeneration,
collapsed
capacity,
virtue
dysfunction,
devascularization,
autophagy,
inflammation.
Nutrients,
Год журнала:
2023,
Номер
15(15), С. 3445 - 3445
Опубликована: Авг. 4, 2023
Obesity
is
a
metabolic
state
generated
by
the
expansion
of
adipose
tissue.
Adipose
tissue
depends
on
interplay
between
hyperplasia
and
hypertrophy,
mainly
regulated
complex
interaction
genetics
excess
energy
intake.
However,
genetic
regulation
yet
to
be
fully
understood.
can
divided
into
common
multifactorial/polygenic
obesity
monogenic
obesity,
non-syndromic
syndromic.
Several
genes
related
were
found
through
studies
models.
syndromic
characterized
additional
features
other
than
suggesting
more
global
role
mutant
syndrome
and,
thus,
an
peripheral
influence
development
hardly
studied
date
in
this
regard.
This
review
summarizes
present
knowledge
regarding
hypertrophy
adipocytes
obesity.
Additionally,
we
highlight
scarce
research
as
model
for
studying
adipocyte
focusing
Bardet–Biedl
(BBS).
BBS
involves
central
mechanisms,
with
molecular
mechanistic
alternation
hypertrophy.
Thus,
argue
that
using
models,
such
BBS,
further
advance
our
Nutrients,
Год журнала:
2024,
Номер
16(4), С. 507 - 507
Опубликована: Фев. 10, 2024
The
escalating
prevalence
of
metabolic
and
cardiometabolic
disorders,
often
characterized
by
oxidative
stress
chronic
inflammation,
poses
significant
health
challenges
globally.
As
the
traditional
therapeutic
approaches
may
sometimes
fall
short
in
managing
these
conditions,
attention
is
growing
toward
nutraceuticals
worldwide;
with
compounds
being
obtained
from
natural
sources
potential
beneficial
effects
shown
to
potentially
support
and,
some
cases,
replace
pharmacological
treatments,
especially
for
individuals
who
do
not
qualify
conventional
treatments.
This
review
delves
into
burgeoning
field
nutraceutical-based
modulation
as
a
promising
strategy
attenuating
inflammation
disorders.
Drawing
an
extensive
body
research,
showcases
various
nutraceutical
agents,
such
polyphenols,
omega-3
fatty
acids,
antioxidants,
which
exhibit
antioxidative
anti-inflammatory
properties.
All
can
be
classified
novel
drugs
that
are
capable
regulating
pathways
mitigate
oxidative-stress-
inflammation-associated
diseases.
By
exploring
mechanisms
through
interact
immune
responses,
this
highlights
their
restore
redox
balance
temper
inflammation.
Additionally,
prospects
interventions
discussed,
encompassing
bioavailability
enhancement,
personalized
treatment
approaches,
clinical
translation.
Through
comprehensive
analysis
latest
scientific
reports,
article
underscores
avenue
fight
complex
landscape
particularly
accentuating
impact
on
cardiovascular
health.
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2436 - 2436
Опубликована: Июль 26, 2024
Adipose
tissue
(AT),
composed
mainly
of
adipocytes,
plays
a
critical
role
in
lipid
control,
metabolism,
and
energy
storage.
Once
considered
metabolically
inert,
AT
is
now
recognized
as
dynamic
endocrine
organ
that
regulates
food
intake,
homeostasis,
insulin
sensitivity,
thermoregulation,
immune
responses.
This
review
examines
the
multifaceted
adiponectin,
predominant
adipokine
released
by
AT,
glucose
fatty
acid
metabolism.
We
explore
regulatory
mechanisms
its
physiological
effects
potential
therapeutic
target
for
metabolic
diseases
such
type
2
diabetes,
cardiovascular
disease
liver
disease.
Furthermore,
we
analyze
impact
various
dietary
patterns,
specific
nutrients,
physical
activities
on
adiponectin
levels,
highlighting
strategies
to
improve
health.
Our
comprehensive
provides
insights
into
functions
importance
maintaining
systemic
homeostasis.
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 310 - 310
Опубликована: Янв. 20, 2024
Obesity
has
been
associated
with
the
occurrence
and
prevalence
of
various
chronic
metabolic
diseases.
The
management
obesity
evolved
to
focus
not
only
on
reducing
weight,
but
also
preventing
obesity-related
complications.
Studies
have
shown
that
bioactive
components
in
natural
products
like
white
kidney
bean
extract
(WKBE),
propolis
ethanolic
(PEE),
chromium
picolinate
(CrPi3)
showed
anti-obesity
properties.
However,
no
studies
examined
outcomes
combining
any
these
nutraceutical
supplements.
We
compared
effects
HFD
supplemented
WKBE,
WKBE+PEE,
or
WKBE+PEE+CrPi3
against
control
obese
groups
using
Sprague-Dawley
rats
fed
a
45%
high-fat
diet
as
an
vivo
model.
Nutritional
parameters,
biochemical
biomarkers
cardiovascular
disease,
liver
function,
gut
health
were
among
comparable
effects.
Our
findings
three
supplements
had
synergetic
effect
weight
gain,
food
utilization
rate,
abdominal
fat,
serum
lipids,
arterial
hepatic
risk
blood
glucose
level,
addition
improving
renal
function
microbiota.
attributed
α-amylase
inhibitor
action
flavonoids,
polyphenol
content
PEE,
which
potentiated
CrPi3
resulting
further
reduction
normalization
certain
parameters.
Polyphenols,
long-used
components
of
medicinal
plants,
have
drawn
great
interest
in
recent
years
as
potential
therapeutic
agents
because
their
safety,
efficacy,
and
wide
range
biological
effects.
Approximately
74%
the
world's
population
still
uses
plant-based
medicines,
indicating
ongoing
significance
phytochemicals
for
human
health.
The
study
emphasizes
growing
body
research
examining
role
polyphenols
uncovering
anti-adipogenic
anti-obesity
properties.
Functions
including
phenylpropanoids,
flavonoids,
terpenoids,
alkaloids,
glycosides,
phenolic
acids
are
distinct
due
to
changes
chemical
diversity,
structural
characteristics.
This
review
methodically
investigates
mechanism
how
naturally
occurring
mediate
obesity
metabolic
function.
To
this
end,
hormonal
control
hunger
has
inhibit
pro-obesity
enzymes
such
pancreatic
lipase,
promotion
energy
expenditure,
modulation
adipocytokine
production.
Specifically,
affect
insulin,
a
hormone
that
is
essential
regulating
blood
sugar,
they
also
play
part
complex
web
factors
progression
obesity.
explores
immunomodulatory
properties
polyphenols,
providing
insight
into
ability
improve
immune
effects
on
gut
health,
improving
number
commensal
bacteria,
cytokine
production
suppression,
cell
mediation,
natural
killer
cells
macrophages.
Taken
together,
continuous
studies
required
prudent
precise
mechanisms
underlying
polyphenols'
immunomodulation.
In
interim,
holistic
approach
health
promotes
consumption
foods
drinks
high
polyphenols.
lays
groundwork
future
developments,
derivatives
may
provide
answer
urgent
worldwide
issues.
compilation
knowledge
paves
way
discoveries
global
treatment
pressing
concerns
diseases.
Biomolecules,
Год журнала:
2024,
Номер
14(2), С. 221 - 221
Опубликована: Фев. 14, 2024
Polyphenols,
long-used
components
of
medicinal
plants,
have
drawn
great
interest
in
recent
years
as
potential
therapeutic
agents
because
their
safety,
efficacy,
and
wide
range
biological
effects.
Approximately
75%
the
world’s
population
still
use
plant-based
compounds,
indicating
ongoing
significance
phytochemicals
for
human
health.
This
study
emphasizes
growing
body
research
investigating
anti-adipogenic
anti-obesity
functions
polyphenols.
The
polyphenols,
including
phenylpropanoids,
flavonoids,
terpenoids,
alkaloids,
glycosides,
phenolic
acids,
are
distinct
due
to
changes
chemical
diversity
structural
characteristics.
review
methodically
investigates
mechanisms
by
which
naturally
occurring
polyphenols
mediate
obesity
metabolic
function
immunomodulation.
To
this
end,
hormonal
control
hunger
has
inhibit
pro-obesity
enzymes
such
pancreatic
lipase,
promotion
energy
expenditure,
modulation
adipocytokine
production.
Specifically,
affect
insulin,
a
hormone
that
is
essential
regulating
blood
sugar,
they
also
play
role,
part,
complex
web
factors
progression
obesity.
explores
immunomodulatory
properties
providing
insight
into
ability
improve
immune
effects
on
gut
health,
improving
number
commensal
bacteria,
cytokine
production
suppression,
cell
mediation,
natural
killer
cells
macrophages.
Taken
together,
continuous
studies
required
understand
prudent
precise
underlying
polyphenols’
In
interim,
holistic
approach
health
promotes
consumption
foods
drinks
high
lays
groundwork
future
developments,
derivatives
may
provide
answer
urgent
worldwide
issues.
compilation
knowledge
paves
way
discoveries
global
treatment
pressing
concerns
diseases.
