International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1455 - 1455
Опубликована: Янв. 11, 2023
Polycyclic
aromatic
hydrocarbons
(PAHs)
are
one
of
the
most
prevalent
classes
environmental
pollutants.
Some
evidence
shows
that
PAHs
could
be
involved
in
human
obesity.
However,
little
is
known
about
distribution
patterns
adipose
tissue
(AT)
and
role
on
adipogenesis/lipogenesis.
The
aims
this
pilot
study
were
to
determine
concentrations
16
defined
as
high-priority
pollutants
plasma
French
Polish
bariatric
patients,
well
their
correlation
with
body
mass
index
(BMI),
AT
adipokines
expression
levels.
We
finally
investigated
naphthalene
cell
proliferation,
viability,
differentiation
3T3-L1
preadipocytes.
concentration
was
similar
three
types
it
significantly
higher
compared
plasma,
suggesting
bioaccumulation.
patients
had
PAH
levels
than
ones.
Only
positively
correlated
BMI
serum
or
chemerin,
adiponectin
resistin
expression,
but
not
who
BMIs.
Moreover,
exposure
increased
proliferation
preadipocytes
lipogenesis,
genes
adipogenesis
after
differentiation.
Taken
together,
more
particularly
an
obesogenic
molecule
increase
risk
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(21), С. 11409 - 11409
Опубликована: Окт. 22, 2021
Obesity
is
a
lipid
metabolism
disorder
caused
by
genetic,
medicinal,
nutritional,
and
other
environmental
factors.
It
characterized
complex
condition
of
excess
accumulation
in
adipocytes.
Adipogenesis
differentiation
process
that
converts
preadipocytes
into
mature
adipocytes
contributes
to
excessive
fat
deposition.
Saikosaponin
A
(SSA)
saikosaponin
D
(SSD)
are
triterpenoid
saponins
separated
from
the
root
Bupleurum
chinensis,
which
has
long
been
used
treat
inflammation,
fever,
liver
diseases.
However,
effects
these
constituents
on
obesity
poorly
understood.
We
investigated
anti-obesity
SSA
SSD
mouse
3T3-L1
The
MTT
assay
was
performed
measure
cell
viability,
Oil
Red
O
staining
conducted
determine
accumulation.
Various
adipogenic
transcription
factors
were
evaluated
at
protein
mRNA
levels
Western
blot
quantitative
reverse
polymerase
chain
reaction
(qRT-PCR).
Here,
we
showed
significantly
inhibited
without
affecting
viability
within
range
tested
concentrations
(0.938-15
µM).
also
dose-dependently
suppressed
expression
peroxisome
proliferator-activated
receptor
gamma
(PPARγ),
CCAAT/enhancer
binding
alpha
(C/EBPα),
sterol
regulatory
element
protein-1c
(SREBP-1c),
adiponectin.
Furthermore,
decrease
transcriptional
resulted
repressed
several
lipogenic
genes
including
fatty
acid
(FABP4),
synthase
(FAS),
lipoprotein
lipase
(LPL).
In
addition,
enhanced
phosphorylation
adenosine
monophosphate-activated
kinase
(AMPK)
its
substrate,
acetyl-CoA
carboxylase
(ACC),
extracellular-regulated
1/2
(ERK1/2)
p38,
but
not
c-Jun-N-terminal
(JNK).
These
results
suggest
inhibit
adipogenesis
through
AMPK
or
mitogen-activated
(MAPK)
pathways
early
stages
adipocyte
differentiation.
This
first
study
anti-adipogenic
SSD,
further
research
animals
humans
necessary
confirm
potential
saikosaponins
as
therapeutic
agents
for
obesity.
Frontiers in Endocrinology,
Год журнала:
2021,
Номер
12
Опубликована: Ноя. 25, 2021
Adult
and
childhood
obesity
have
reached
pandemic
level
proportions.
The
idea
that
caloric
excess
insufficient
levels
of
physical
activity
leads
to
is
a
commonly
accepted
answer
for
unwanted
weight
gain.
This
paradigm
offers
an
inconclusive
explanation
as
the
world
continually
moves
towards
unhealthier
heavier
existence
irrespective
energy
balance.
Endocrine
disrupting
chemicals
(EDCs)
are
resemble
natural
hormones
disrupt
endocrine
function
by
interfering
with
body’s
endogenous
hormones.
A
subset
EDCs
called
obesogens
been
found
cause
metabolic
disruptions
such
increased
fat
storage,
in
vivo
.
Obesogens
act
on
system
through
multiple
avenues
affect
homeostasis
variety
systems
gut
microbiome
adipose
tissue
functioning.
Obesogenic
compounds
shown
disturbances
later
life
can
even
pass
into
future
generations,
post
exposure.
rising
rates
related
disease
demanding
increasing
attention
chemical
screening
efforts
worldwide
preventative
strategies
keep
public
generations
safe.
review
addresses
most
current
findings
known
their
effects
system,
mechanisms
action
which
they
upon,
were
identified
with.
interplay
between
obesogens,
brown
tissue,
major
topics
will
be
covered.
Obesity,
Год журнала:
2022,
Номер
30(3), С. 666 - 679
Опубликована: Фев. 16, 2022
Abstract
Objective
This
study
examined
the
effects
of
miR‐122–enriched
exosomes
on
expression
vitamin
D3
receptor
(VDR)
and
sterol
regulatory
element‐binding
transcription
factor
1
(SREBF1)
their
roles
during
adipogenesis.
Methods
The
miR‐122,
SREBF1,
VDR
were
investigated
relationships
between
miR‐122
or
SREBF1
assessed
by
dual‐luciferase
reporter
chromatin
immunoprecipitation
assays.
potential
role
miR‐122/VDR/SREBF1
was
evaluated
in
high‐fat
diet‐induced
obese
male
mice.
Results
High
levels
found
only
adipose
tissue‐derived
(Exo‐AT)
Exo‐AT–treated
cells.
Overexpression
promoted
adipogenesis,
inhibition
prevented
adipogenesis
regulating
VDR,
peroxisome
proliferator‐activated
gamma,
lipoprotein
lipase,
adiponectin.
Knockdown
Srebf1
overexpression
could
inhibit
However,
exosomal
reverse
inhibitory
effects.
assay
assays
confirmed
that
a
direct
target
miR‐122.
It
bind
to
BS1
region
promoter
expression.
Moreover,
alleviate
obesity
mice,
possibly
through
upregulating
VDR/SREBF1
axis.
Conclusion
MiR‐122–enriched
Exo‐AT
Consumption
of
prebiotics
and
plant-based
compounds
have
many
beneficial
health
effects
through
modulation
gut
microbiota
composition
are
considered
as
promising
nutritional
strategy
for
the
treatment
metabolic
diseases.
In
present
study,
we
assessed
separated
combined
inulin
rhubarb
on
diet-induced
disease
in
mice.
We
showed
that
supplementation
with
both
abolished
total
body
fat
mass
gain
upon
high-fat
high-sucrose
diet
(HFHS)
well
several
obesity-associated
disorders.
These
were
associated
increased
energy
expenditure,
lower
whitening
brown
adipose
tissue,
higher
mitochondria
activity
expression
lipolytic
markers
white
tissue.
Despite
modifications
intestinal
bile
acid
compositions
by
or
alone,
combination
had
minor
additional
impact
these
parameters.
However,
antimicrobial
peptides
goblet
cell
numbers,
thereby
suggesting
a
reinforcement
barrier.
Together,
results
suggest
mice
potentiates
HFHS-related
could
be
prevention
obesity
related
pathologies.
Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Дек. 12, 2023
Grape
leaves,
scientifically
known
as
Vitis
vinifera,
the
primary
by-product
obtained
after
processing
of
grapes,
are
gathered
in
enormous
amounts
and
disposed
agricultural
waste.
For
more
sustainable
agriculture
better
food
systems,
it
is
crucial
to
investigate
these
byproducts’
nutritional
values.
The
bioactive
compounds
present
grape
leaves
quercetin,
resveratrol,
caffeic
acid,
kaempferol,
gallic
which
favour
pharmacological
effects
on
human
health
such
antioxidant,
anti-inflammatory,
anti-obesity,
anti-diabetic,
hepatoprotective.
Furthermore,
extract
has
been
used
a
functional
ingredient
for
creating
both
non-food
products.
aim
current
review
phytochemical
composition
various
varieties
their
health-promoting
characteristics
applications.
study
also
highlights
extraction
techniques
including
conventional
non-conventional
methods
extracting
leaves.
bioactives
can
be
extracted
using
environmentally
safe
processes,
line
with
rising
demand
eco-friendly
healthful
products
worldwide.
These
perfectly
suited
changing
needs
customers
industries
since
they
lessen
environmental
effect,
enhance
product
quality,
offer
financial
advantages.
Nutrients,
Год журнала:
2023,
Номер
15(24), С. 5082 - 5082
Опубликована: Дек. 12, 2023
Endoplasmic
reticulum
(ER)
stress
plays
a
pivotal
role
in
adipogenesis,
which
encompasses
the
differentiation
of
adipocytes
and
lipid
accumulation.
Sustained
ER
has
potential
to
disrupt
signaling
unfolded
protein
response
(UPR),
thereby
influencing
adipogenesis.
This
comprehensive
review
illuminates
molecular
mechanisms
that
underpin
interplay
between
We
delve
into
dysregulation
UPR
pathways,
namely,
IRE1-XBP1,
PERK
ATF6
relation
adipocyte
differentiation,
metabolism,
tissue
inflammation.
Moreover,
we
scrutinize
how
impacts
key
adipogenic
transcription
factors
such
as
proliferator-activated
receptor
γ
(PPARγ)
CCAAT-enhancer-binding
proteins
(C/EBPs)
along
with
their
interaction
other
pathways.
The
cellular
ramifications
include
alterations
adipokines,
aged
adipose
also
discuss
roles
chaperones
cyclophilin
A
B
play
By
shedding
light
on
intricate
relationship
this
paves
way
for
devising
innovative
therapeutic
interventions.
