Integrative Transcriptomics and Proteomics Analysis Reveals THRSP’s Role in Lipid Metabolism DOI Open Access
Yujie Li, Ke Xu,

Ao Zhou

и другие.

Genes, Год журнала: 2024, Номер 15(12), С. 1562 - 1562

Опубликована: Ноя. 30, 2024

Background/Objectives: Abnormalities in lipid metabolism and endoplasmic reticulum (ER) stress are strongly associated with the development of a multitude pathological conditions, including nonalcoholic fatty liver disease (NAFLD), diabetes mellitus, obesity. Previous studies have indicated potential connection between thyroid hormone responsive (THRSP) that ER may participate synthesis key regulators adipogenesis. However, specific mechanisms remain to be investigated. Methods: In this study, we explored roles THRSP by interfering gene expression mouse mesenchymal stem cells, comparing effects on adipogenesis control interfered groups, combining transcriptomic proteomic analysis. Results: Our results showed number droplets was significantly reduced after THRSP, levels adipogenesis, such as LPL, FABP4, PLIN1, CIDEC, were downregulated. Both differential genes (proteins) enriched processes lipolytic regulation, stress, cholesterol metabolism, sphingolipid PPAR signaling pathway, glycerophospholipid metabolism. The marker gene, ATF6, most downregulated transcription factor. addition, RT-qPCR validation pathway SCD1; droplet generation LIPE, DGAT1, AGPAT2; ATF6 Conclusions: These suggest is involved regulating which closely related Interfering helpful ameliorating occurrence diseases abnormalities

Язык: Английский

Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species DOI Open Access

Songhyun Ju,

Manish Kumar Singh,

Sunhee Han

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12387 - 12387

Опубликована: Ноя. 18, 2024

Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve signaling agents that enhance cell proliferation, migration, resistance to drugs. However, at elevated levels, induce oxidative stress, causing damage biomolecules leading death. cells developed mechanisms manage activating pathways such NRF2, NF-κB, PI3K/Akt. This review explores relationship between cancer, focusing on death like apoptosis, ferroptosis, autophagy, highlighting potential strategies exploit target cells.

Язык: Английский

Процитировано

11
Role of Autophagy and AMPK in Cancer Stem Cells: Therapeutic Opportunities and Obstacles in Cancer DOI Open Access

Lochana Kovale,

Manish Kumar Singh, Joungmok Kim

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8647 - 8647

Опубликована: Авг. 8, 2024

Cancer stem cells represent a resilient subset within the tumor microenvironment capable of differentiation, regeneration, and resistance to chemotherapeutic agents, often using dormancy as shield. Their unique properties, including drug metastatic potential, pose challenges for effective targeting. These exploit certain metabolic processes their maintenance survival. One these is autophagy, which generally helps in energy homeostasis but when hijacked by CSCs can help maintain stemness. Thus, it referred an Achilles heel CSCs, cancers tend depend on autophagy Autophagy, while crucial maintaining stemness cancer (CSCs), also serve vulnerability contexts, making complex target therapy. Regulators like AMPK (5' adenosine monophosphate-activated protein kinase) play role helping reprogramming harsh environments. The purpose this review elucidate interplay between highlighting targeting discussing therapeutic strategies overcome limitations. This focuses previous research its regulators biology, particularly addresses remaining unanswered questions, potential targets therapy are brought attention.

Язык: Английский

Процитировано

5
Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS) DOI
Liang Chen, Mingyang Chen, Zhaomei Mu

и другие.

Biological Trace Element Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

0
Role of adipose tissue in people with obesity and its relationship with the appearance of metabolic diseases DOI Open Access

Steven M. Suárez Velastegui,

Carmen P. Montes Castro,

Myrna A. Córdova Perugachi

и другие.

International Journal of Research in Medical Sciences, Год журнала: 2025, Номер 13(2), С. 911 - 916

Опубликована: Янв. 30, 2025

The alteration of adipose tissue plays a fundamental role in the appearance chronic inflammation diseases; insulin resistance, lipid deposition obese patients. In recent years it has been shown that under stimulation adipocytes stressful situations, their endoplasmic reticulum generates response over activates inflammatory and interferes with normal mentalism, generating secretion adipokines, affecting thermogenic pathways tissue. adipose, which causes manifestation metabolic syndrome. This article summarizes relationship between adipocyte dysfunction

Язык: Английский

Процитировано

0
New insights into the antiadipogenic effect of dihydromyricetin by restoring lipid homeostasis between TG and PE in white adipose tissue DOI
Lu Liu, Nan Dong,

Hong Cui

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106151 - 106151

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication DOI Creative Commons

Jingyu Xu,

B Wang,

Haiqing Ao

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 20, 2025

The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that regulates secretion along the hypothalamic-pituitary-adrenal (HPA) axis, mediates neurotransmission humoral regulation. Due widespread expression of receptors (GR), effects CORT are almost ubiquitous in various tissue cells. Therefore, on one hand, is molecular signal activates body’s system during other due chemical properties GCs, anti-inflammatory act as stabilizers control response stress. Inflammation manifestation activation. plays dual roles this process both promoting inflammation exerting As hormone, levels fluctuate with degree duration stress, determining its changes it induces. essential for resist diseases maintain homeostasis, imbalance being key factor development diseases. understanding role mechanisms action immunity crucial. This review addresses important issue summarizes interactions between system.

Язык: Английский

Процитировано

0
Implications of obesity-mediated cellular dysfunction and adipocytokine signaling pathways in the pathogenesis of osteoarthritis DOI
Dahye Kim, Md. Meraj Ansari, Mrinmoy Ghosh

и другие.

Molecular Aspects of Medicine, Год журнала: 2025, Номер 103, С. 101361 - 101361

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
The double whammy of ER-retention and dominant-negative effects in numerous autosomal dominant diseases: significance in disease mechanisms and therapy DOI Creative Commons

Nesrin Gariballa,

Feda E. Mohamed, Sally Badawi

и другие.

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Июнь 27, 2024

The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded, processed and assembled proteins exit ER reach their functional destinations. Mutant unable attain correct tertiary conformation or form complexes with partners are retained in subsequently degraded through ER-associated degradation (ERAD) associated mechanisms. retention contributes a spectrum monogenic diseases diverse modes inheritance molecular In autosomal dominant diseases, when mutant get ER, they can interact wild-type counterparts. This interaction may lead formation mixed dimers aberrant complexes, disrupting normal trafficking function dominant-negative manner. combination effects has been frequently documented cause significant loss proteins, thereby exacerbating disease severity. review aims examine existing literature provide insights into impact exerted by range including skeletal connective tissue disorders, vascular neurological eye disorders serpinopathies. Most crucially, we aim emphasize importance this area research, offering substantial potential for understanding factors influencing phenotypic variability genetic variants. Furthermore, highlight current prospective therapeutic approaches targeted at ameliorating mutations exhibiting effects. These encompass experimental studies exploring treatments translation clinical practice.

Язык: Английский

Процитировано

3
Microbiological and functional traits of peri-implant mucositis and correlation with disease severity DOI Creative Commons

Ziying Feng,

Jinzan Zhu,

Limin Zhang

и другие.

mSphere, Год журнала: 2024, Номер 9(7)

Опубликована: Июль 9, 2024

Osseointegrated dental implants replace missing teeth and create an artificial surface for biofilms of complex microbial communities to grow. These on surfaces can trigger infection inflammation in the surrounding tissue. This study investigated characteristics peri-implant mucositis (PM) explored correlation between ecological imbalance, community function, disease severity by comparing submucosal microflora from PM with those healthy inter-subject intra-subject gingivitis (G) within a group 32 individuals. We analyzed plaques PM, implant (HI), G sites using metagenome shotgun sequencing. The bacterial diversity HIs was higher than that according Simpson index. Beta revealed differences taxonomic functional compositions across groups. Linear discriminant analysis effect size identified 15 genera 37 species as biomarkers distinguished HIs. Pathways involving cell motility protein processing endoplasmic reticulum were upregulated while pathways related metabolism cofactors vitamins downregulated. Microbial dysbiosis correlated positively clinical measured sulcus bleeding index (SBI) PM.

Язык: Английский

Процитировано

2
Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity DOI Creative Commons

Yu Jiang,

Jiaqi Guo,

Ya Wu

и другие.

Therapeutic Advances in Endocrinology and Metabolism, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

As the prevalence of obesity continues to rise globally, research on adipocytes has attracted more and attention. In presence nutrient overload, are exposed pressures such as hypoxia, inflammation, mechanical stress, metabolite, oxidative stress that can lead organelle dysfunction. Endoplasmic reticulum (ER) is a vital for sensing cellular pressure, its homeostasis essential maintaining adipocyte function. Under conditions excess nutrition, ER (ERS) will be triggered by gathering abnormally folded proteins in lumen, resulting activation signaling response known unfolded protein responses (UPRs), which system relieve ERS restore homeostasis. However, if UPRs fail rescue homeostasis, activate pathways damage cells. Studies have shown role disturbed pathophysiology complications. Prolonged or excessive aggravate lipolysis, insulin resistance, apoptosis affect bioactive molecule production. addition, also impacts expression some important genes. view fact influences function through various mechanisms, targeting may viable strategy treat obesity. This article summarizes effects during

Язык: Английский

Процитировано

2