Antioxidants, Год журнала: 2024, Номер 13(4), С. 393 - 393
Опубликована: Март 25, 2024
The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.
Язык: Английский
Процитировано
45The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline
Опубликована: Авг. 12, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.
Язык: Английский
Процитировано
15Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions
Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096
Опубликована: Сен. 13, 2024
The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.
Язык: Английский
Процитировано
8The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Янв. 29, 2025
The intricate relationship between dietary habits and cognitive function is gaining increasing attention, with a focus on the gut-brain axis as modifiable target for intervention. This review synthesizes evidence impact of patterns, particularly Mediterranean diet, plant-based diets, low-carbohydrate health. These rich in antioxidants, anti-inflammatory compounds, neuroprotective nutrients, are suggested to slow decline reduce risk neurodegenerative disorders through mechanisms such reduced inflammation oxidative stress, enhanced neurogenesis. diet has been associated improved performance delay elderly populations. However, challenges intervention implementation, including adherence individual variability, remain. Future research must adopt multidisciplinary approach, incorporating long-term, large-scale, multicenter randomized controlled trials assess enduring impacts various patterns function, considering socioeconomic cultural factors. underscores potential interventions prevent mitigate impairment, ultimately aiming improve quality life.
Язык: Английский
Процитировано
1Metabolically Healthy Obesity Is Characterized by a Distinct Proteome Signature
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2262 - 2262
Опубликована: Март 4, 2025
Obesity is commonly associated with metabolic diseases including type 2 diabetes, hypertension, and dyslipidemia. Moreover, individuals obesity are at increased risk of cardiovascular disease. However, a subgroup within the obese population presents without concurrent disorders. Even though this group has stable status does not exhibit overt disease, may be transient; these have subclinical derangements. To investigate latter hypothesis, an analysis proteome signature was conducted. Plasma samples from 27 subjects but disorder (obesity only (OBO)) 15 lean healthy control (LHC) were examined. Fasting subjected to Olink proteomics targeting 184 proteins enriched in cardiometabolic inflammation pathways. Our results distinctly delineated two groups distinct plasma protein expression profiles. Specifically, total 24 differentially expressed compared LHC. Among these, 13 downregulated, whereas 11 upregulated. The pathways that upregulated OBO related chemoattractant activity, growth factor G protein-coupled receptor binding, chemokine cytokine downregulated include regulation T cell differentiation, leukocyte reproductive system development, inflammatory response, neutrophil, lymphocyte, monocyte chemotaxis, neutrophil migration. study identifies several altered subjects. These findings provide valuable insights into underlying mechanisms, potentially paving way for identification therapeutic targets aimed improving health obesity.
Язык: Английский
Процитировано
0Parkinson’s disease and metabolic disorders, understanding their shared co-morbidity through the autonomic nervous system
Advances in genetics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0A Combined GLP-1/PPARa/CB1-Based Therapy to Restore theCentral and Peripheral Metabolic Dysregulation Induced by a High-Fructose High-Fat Diet
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2420 - 2420
Опубликована: Март 7, 2025
Obesity remains a major epidemic in developed countries, with limited range of effective pharmacological treatments. The modulation PPARα, CB1, or GLP-1 receptor activity has demonstrated beneficial effects, including anti-obesity actions. In this study, we evaluated novel amide derivative oleic acid and tyrosol (Oleyl hydroxytyrosol ether, OLHHA), PPARα agonist, CB1 antagonist, combination the agonist liraglutide (LIG), as an multitarget therapy to improve both peripheral central alterations animal model diet-induced obesity. rats, exposure high-fat high-fructose diet (HFHFD) induced weight gain increased plasma triglycerides, LDL, hepatic parameters. brain, HFHFD provoked disruptions expression proteins regulating food intake, endocannabinoid system, insulin pathway, inflammation resulted altered tau phosphorylation, thus indicating neurodegenerative changes. Based on our results, administration LIG OLHHA alone was insufficient completely reverse noticed at levels. On other hand, combined treatment compounds (OLHHA+LIG) most promoting body loss ameliorating by HFHFDs rats. This therapeutic approach could represent promising strategy for treating obesity associated comorbidities.
Язык: Английский
Процитировано
0Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity
Cells, Год журнала: 2025, Номер 14(8), С. 580 - 580
Опубликована: Апрель 11, 2025
Recent advances in drug development allowed for the identification of THRβ-selective thyromimetic TG68 as a very promising lipid lowering and anti-amyloid agent. In current study, we first investigated neuroprotective effects on vitro human models neuroinflammation β-amyloid neurotoxicity order to expand our knowledge therapeutic potential this novel thyromimetic. Subsequently, examined metabolic inflammatory profiles, along with cognitive changes, using high-fat diet (HFD) mouse model obesity. Our data demonstrated that was able prevent either LPS/TNFα-induced response or β-amyloid-induced cytotoxicity microglial (HMC3) cells. Next, HFD-fed mice, treatment (10 mg/kg/day; 2 weeks) significantly reduced anxiety-like behavior stretch–attend posture (SAP) tests while producing 12% BW loss significant decrease blood glucose levels. Notably, these highlight close relationship between improved serum parameters reduction anxious behavior. Moreover, administration observed efficiently counteract HFD-altered central peripheral expressions mice selected biomarkers dysfunction, inflammation, neurotoxicity, revealing effects. conclusion, work provides preliminary evidence may represent opportunity interlinked diseases such obesity neurodegenerative diseases.
Язык: Английский
Процитировано
0Evaluating the Causal Association Between Type 2 Diabetes and Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study
Biomedicines, Год журнала: 2025, Номер 13(5), С. 1095 - 1095
Опубликована: Апрель 30, 2025
Background/Objectives: Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are significant global health issues. Epidemiological studies suggest T2DM increases AD risk, though confounding factors reverse causality complicate this association. This study aims to clarify the causal relationship between through a systematic review meta-analysis of Mendelian randomization (MR) new two-sample MR analysis. Methods: A literature search across major databases was conducted May 2024 identify linking AD. Fixed/random-effect models provided pooled odds ratios (ORs) with 95% confidence intervals (CIs), heterogeneity assessed I2 statistic. For our analysis, we genetic variants from selected analyzed outcomes using IGAP, EADB, UKB databases. Multiple methods, including inverse variance weighted (IVW) pleiotropy-robust approaches, were applied for validation. Results: Of 271 articles, 8 included (sample sizes: 68,905 788,989), all European ancestry. Our found no link (OR = 1.02, CI: 1.00-1.04) moderate (I2 31.3%). Similarly, analysis 512 SNPs as instrumental variables showed associations in or data, which is consistent sensitivity analyses. Conclusions: meta-MR revealed association AD, indicating that predisposition does not appear causally influence modifiable clinical environmental aspects may still contribute neurodegenerative processes. Further research should explore other mechanisms these conditions.
Язык: Английский
Процитировано
0Increased rubidium levels in brain regions involved in food intake in obese rats
Brain Structure and Function, Год журнала: 2025, Номер 230(5)
Опубликована: Май 15, 2025
Язык: Английский
Процитировано
0