Insights Into the Therapeutic Potential of SIRT1-modifying Compounds for Alzheimer’s Disease: A Focus on Molecular Mechanisms

Journal of Molecular Neuroscience, Год журнала: 2025, Номер 75(1)

Опубликована: Фев. 25, 2025

Язык: Английский

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Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders

Nutritional Neuroscience, Год журнала: 2025, Номер unknown, С. 1 - 26

Опубликована: Март 3, 2025

Background: Curcumin, a polyphenolic compound derived from Curcuma longa, exhibits significant neuroprotective potential due to its diverse pharmacological properties.Objective: This review explores curcumin's role in modulating key pathological mechanisms underlying neurodegenerative disorders such as Alzheimer's, Parkinson's diseases, Amyotrophic Lateral Sclerosis, Huntington's Disease and Prion Disease.Methods: A comprehensive analysis of molecular interactions, including effects on amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress, metal-induced neurotoxicity, was conducted. Additionally, strategies overcome low bioavailability blood-brain barrier (BBB) permeability were evaluated.Results: Curcumin inhibits Aβ aggregation promotes disaggregation, reducing amyloid plaque formation Alzheimer's disease. It modulates glial cell activity, attenuating neuroinflammation fostering environment. By interacting with proteins, curcumin prevents hyperphosphorylation neurofibrillary tangle formation. As potent antioxidant, it scavenges reactive oxygen species, mitigating stress-related neuronal damage. Its metal-chelating properties further diminish neurotoxicity by sequestering iron copper ions. Despite limited BBB permeability, therapeutic efficacy can be enhanced using nanocarriers nanoparticles, liposomes, micelles, which improve solubility, stability, brain penetration.Conclusion: Curcumin's multifaceted make promising candidate for preventing or slowing disease progression. Advanced drug delivery systems hold overcoming pharmacokinetic limitations, paving the way future clinical applications.

Язык: Английский

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Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 1869 - 1894

Опубликована: Март 1, 2025

Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A mouse model was established by D-gal induction, effects CI evaluated through behavioral tests, pathological staining, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, network pharmacology analyze potential which improves followed validation Western blotting (WB), traditional Chinese medicine (TEM), Immunofluorescence (IF), 16S rRNA. can each alleviate decline neuropathological damage mice varying degrees, reduce expression pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, LPS) serum or hippocampal tissue, increase SOD GSH levels. Network analysis molecular experiments confirmed that upregulates tight junction s (TJs), enhances proteins cAMP pathway, inhibits p-NF-κB-p65 expression. reverses D-gal-induced gut microbiota dysbiosis, increases abundance SCFA-producing bacteria, decreases LPS-producing bacteria. alleviates reducing inflammation oxidative stress, protecting blood-brain barrier (BBB) intestinal barrier, inhibiting NF-κB activating regulating microbiota.

Язык: Английский

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Advancing Alzheimer’s disease therapy through engineered exosomal Macromolecules

Brain Research, Год журнала: 2025, Номер unknown, С. 149590 - 149590

Опубликована: Март 1, 2025

Язык: Английский

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Siddha medicine and modern neuroscience: a synergistic approach to neurological care

3 Biotech, Год журнала: 2025, Номер 15(4)

Опубликована: Март 21, 2025

Язык: Английский

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Integrating network pharmacology and in vivo study to explore the anti-Alzheimer’s potential of Bergenia ligulata and Nelumbo nucifera

3 Biotech, Год журнала: 2025, Номер 15(5)

Опубликована: Апрель 3, 2025

Язык: Английский

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Transthyretin as a therapeutic target: the future of disease-modifying therapies for Alzheimer’s disease

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 8, 2025

Язык: Английский

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Unravelling the role of protein kinase R (PKR) in neurodegenerative disease: a review

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 9, 2025

Язык: Английский

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Current study on Pyrroloquinoline quinone (PQQ) therapeutic role in neurodegenerative diseases

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 15, 2025

Язык: Английский

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Correlation of autophagy and Alzheimer's disease with special emphasis on the role of phosphodiesterase-4

3 Biotech, Год журнала: 2025, Номер 15(5)

Опубликована: Апрель 23, 2025

Язык: Английский

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