Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Aug. 17, 2024
Language: Английский
Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)
Published: Aug. 17, 2024
Language: Английский
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1869 - 1894
Published: March 1, 2025
Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A mouse model was established by D-gal induction, effects CI evaluated through behavioral tests, pathological staining, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, network pharmacology analyze potential which improves followed validation Western blotting (WB), traditional Chinese medicine (TEM), Immunofluorescence (IF), 16S rRNA. can each alleviate decline neuropathological damage mice varying degrees, reduce expression pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, LPS) serum or hippocampal tissue, increase SOD GSH levels. Network analysis molecular experiments confirmed that upregulates tight junction s (TJs), enhances proteins cAMP pathway, inhibits p-NF-κB-p65 expression. reverses D-gal-induced gut microbiota dysbiosis, increases abundance SCFA-producing bacteria, decreases LPS-producing bacteria. alleviates reducing inflammation oxidative stress, protecting blood-brain barrier (BBB) intestinal barrier, inhibiting NF-κB activating regulating microbiota.
Language: Английский
Citations
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Language: Английский
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Language: Английский
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Language: Английский
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Language: Английский
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Language: Английский
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Language: Английский
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Language: Английский
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Published: April 29, 2025
Language: Английский
Citations
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