Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1869 - 1894

Published: March 1, 2025

Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A mouse model was established by D-gal induction, effects CI evaluated through behavioral tests, pathological staining, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, network pharmacology analyze potential which improves followed validation Western blotting (WB), traditional Chinese medicine (TEM), Immunofluorescence (IF), 16S rRNA. can each alleviate decline neuropathological damage mice varying degrees, reduce expression pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, LPS) serum or hippocampal tissue, increase SOD GSH levels. Network analysis molecular experiments confirmed that upregulates tight junction s (TJs), enhances proteins cAMP pathway, inhibits p-NF-κB-p65 expression. reverses D-gal-induced gut microbiota dysbiosis, increases abundance SCFA-producing bacteria, decreases LPS-producing bacteria. alleviates reducing inflammation oxidative stress, protecting blood-brain barrier (BBB) intestinal barrier, inhibiting NF-κB activating regulating microbiota.

Language: Английский

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Advancing Alzheimer’s disease therapy through engineered exosomal Macromolecules

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149590 - 149590

Published: March 1, 2025

Language: Английский

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Siddha medicine and modern neuroscience: a synergistic approach to neurological care

3 Biotech, Journal Year: 2025, Volume and Issue: 15(4)

Published: March 21, 2025

Language: Английский

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Integrating network pharmacology and in vivo study to explore the anti-Alzheimer’s potential of Bergenia ligulata and Nelumbo nucifera

3 Biotech, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 3, 2025

Language: Английский

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Transthyretin as a therapeutic target: the future of disease-modifying therapies for Alzheimer’s disease

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 8, 2025

Language: Английский

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Unravelling the role of protein kinase R (PKR) in neurodegenerative disease: a review

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 9, 2025

Language: Английский

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Current study on Pyrroloquinoline quinone (PQQ) therapeutic role in neurodegenerative diseases

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 15, 2025

Language: Английский

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Correlation of autophagy and Alzheimer's disease with special emphasis on the role of phosphodiesterase-4

3 Biotech, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 23, 2025

Language: Английский

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Iridoid Glycosides in Kidney-Tonifying Chinese medicinal herbs: Mechanisms and Implications for Alzheimer’s Disease Therapy

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 348, P. 119870 - 119870

Published: April 25, 2025

Language: Английский

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Unraveling the role of CGRP in neurological diseases: a comprehensive exploration to pathological mechanisms and therapeutic implications

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 29, 2025

Language: Английский

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