A review of the genotoxic effects of antiparasitic drugs on parasites and their hosts

Regulatory Toxicology and Pharmacology, Год журнала: 2025, Номер unknown, С. 105797 - 105797

Опубликована: Фев. 1, 2025

Язык: Английский

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Screening Potential Inhibitors of Plasmodium falciparum Purine Nucleoside Phosphorylase (PfPNP) Using a Computational Approach

Indus journal of bioscience research., Год журнала: 2025, Номер 3(2)

Опубликована: Март 18, 2025

Background: Pneumonia is an inflammatory condition of the lungs caused by bacterium Streptococcus pneumoniae. It a significant cause mortality and morbidity, particularly among young children, adults immunocompromised persons. Resistance against drugs continuously evolving in nearly all pathogens. The constant need for alternative therapeutic options demands necessity ongoing search novel drugs. Objective: current study was thus designed to target penicillin binding protein pneumoniae (PBP1a), involved critical cellular metabolic processes. Method: PBP1a sequence obtained from UniProt database BLAST performed. 3D structure downloaded RCSB visualized using Discovery Studio Visualizer. 150 were docked PatchDock web server interactions explored GS Viewer, LigPlot+ Result: Out chosen, Lamivudine, Dolutegravir Loperamide showed most with PBP1a. These included covalent bonds, hydrogen bonds hydrophobic interactions. Conclusion: interacted uniquely protein. may trigger changes could inhibit growth kill parasite. Further experimental needed fully understand potential these

Язык: Английский

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Morphology of the male reproductive system and spermatozoa variation in Anopheles darlingi (Diptera: Culicidae)

Journal of Medical Entomology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Abstract In this study, we present an analysis of the male reproductive system and spermatozoa Anopheles darlingi Root, 1926, primary malaria vector in Brazil. The consists a pair unifollicular testes, deferent ducts, muscular ejaculatory duct, accessory glands. average length was 188 µm, with continuous variation from 92 to 246 µm. This significant may be associated mosquito’s copulatory behavior, which females are monandrous. scenario reduce selective pressure for uniformity gametes species.

Язык: Английский

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Machine learning evidence towards eradication of malaria burden: A scoping review

Applied Computer Science, Год журнала: 2025, Номер 21(1), С. 44 - 69

Опубликована: Март 31, 2025

Recent advancements have shown that shallow and deep learning models achieve impressive performance accuracies of over 97% 98%, respectively, in providing precise evidence for malaria control diagnosis. This effectiveness highlights the importance these enhancing our understanding management, which includes critical areas such as control, diagnosis economic evaluation burden. By leveraging predictive systems models, significant opportunities eradicating malaria, empowering informed decision-making facilitating development effective policies could be established. However, global burden is approximated at 95%, there a pressing need its eradication to facilitate achievement SDG targets related good health well-being. paper presents scoping review covering years 2018 2024, utilizing PRISMA-ScR protocol, with articles retrieved from three scholarly databases: Science Direct (9%), PubMed (41%), Google Scholar (50%). After applying exclusion inclusion criteria, final list 61 was extracted review. The results reveal decline research on machine techniques while steady increase approaches has been noted, particularly volume dimensionality data continue grow. In conclusion, clear utilize algorithms through real-time collection, model development, deployment evidence-based recommendations Future directions should focus standardized methodologies effectively investigate both models.

Язык: Английский

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Delays in seeking healthcare and its determinants among malaria patients in Ethiopia: A systematic review and meta-analysis

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0320149 - e0320149

Опубликована: Апрель 8, 2025

Delays in seeking healthcare among malaria patients are typically associated with an increased risk of severe disease and mortality. Determining the pooled prevalence determinants delays may help reduce morbidity Therefore, aim this systematic review meta-analysis was to determine its Ethiopia. Methods PubMed, Cochrane Library, Scopus, Web Science, Google Scholar were searched. Cross-sectional case–control studies about for more than 24 hours included. STATA 17 used analyze data. Heterogeneity across assessed via I 2 test. A funnel plot Egger’s test assess publication bias. Subgroup analyses performed by region study setting. Sensitivity analysis influence individual studies. Results total 18 articles 7371 participants included review. The delay 67% (95% CI: 51%-84%). Age less 15 years (OR: 2.27, 95% 1.34-3.85), inability read write 3.36, 1.18-9.69), travel health institutions on foot 2.77, 1.71-4.49), horse 2.76, 1.57-4.84), living far from a institution 2.65, 1.37-5.13), not having family history death 3.04, 2.14-4.33), being member community-based insurance 7.14, 1.09-46.63) significant healthcare. Conclusion high, most modifiable. These findings underscore need targeted interventions address these barriers improve timely access affected populations.

Язык: Английский

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Facile Synthesis, Characterization and in vitro Biological Evaluation of a Series of Sulfonylurea-linked Quinoline Derivatives as Potential Antimalarial Agents

Asian Journal of Chemistry, Год журнала: 2025, Номер 37(5), С. 1083 - 1089

Опубликована: Апрель 30, 2025

World Health Organization (WHO) statistics showed that malaria has still remained a global threat due to its steady increase in deaths across the globe. Due necessity for novel pharmaceuticals, researchers discovered hybrid pharmacophore-designed methodology would be an effective means develop new synthetic compounds and evaluate their efficacy against malaria. Therefore, series of sulfonylurea-linked quinolines (C1-C6) were synthesized evaluated vitro antimalarial properties Plasmodium falciparum. All screened through bioassays assess potential P. falciparum strain identify bioactive hit molecule; relatively compared with clinically proven agent e.g. artesunate. Based on results, structure-activity relationships (SARs) have been derived can applied design more analogues. Among tested, C3 C2 reported most potent 68.10% 65.55% inhibition parasitemia infected red blood cells (iRBC) positive standard artesunate 64.98%, respectively. The assumed primarily presence complementary pharmacophoric features such as sulfonylurea quinoline, which formed part basic scaffold was earlier independently well established pharmacophores.

Язык: Английский

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Next-Generation Biotechnology Tool in Mitigation of Resistance to Carbamates Insecticides in Anopheles gambiae

Опубликована: Янв. 1, 2025

Язык: Английский

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Investigation of New 4-Benzyloxy-2-trichloromethylquinazoline Derivatives as Plasmodium falciparum Dihydrofolate Reductase-thymidylate Synthase Inhibitors: QSAR, ADME, Drug-likeness, Toxicity, Molecular Docking and Molecular Dynamics Simulation

Journal of Multidisciplinary Applied Natural Science, Год журнала: 2025, Номер unknown

Опубликована: Май 18, 2025

Plasmonium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) is one of the most crucial antimalarial targets. Mutations in binding pocket this target lead to resistance antifolate. The mutations influence amino acid residues at points 51, 59, 108 and 164 contribute significantly malaria not being treated well. Priority should therefore be given development antifolate-resistance drugs. These studies aim investigate new 4-benzyloxy-2-trichloromethylquinazoline derivatives as PfDHFR-TS inhibitors using QSAR, ADME, drug-likeness, toxicity, molecular docking studies, dynamics simulations. best equation model from QSAR analysis used MLR PLS statistics show that pIC50 linearly related GATS4e, SpMax AEA(ed), Mor28e, but inverted when compared ATS6m ATSC7m. predictive ability was confirmed by internal external validation. In addition, Y-randomization validation showed reliable, robust, stable, with a cRp2 score over 0.5. ADME drug-likeness predictions design for molecules S10, S23 S64. Based on toxicity results, three are expected have moderate non-toxic properties, starting then S10 Molecular all high energies, 9.869, 9.589, 9.565 kcal/mol. Leu46, Asp54, Ser111, Thr185 play major role ligand-receptor interaction quadruple mutant PfDHFR-TS. Furthermore, an evaluation simulations complexes S10-3JSU, S23-3JSU S64-3JSU demonstrated stable interactions 100 ns.

Язык: Английский

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A mathematical model of malaria transmission in conflict-affected regions and the implications on malaria interventions

Scientific African, Год журнала: 2025, Номер unknown, С. e02746 - e02746

Опубликована: Май 1, 2025

Язык: Английский

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Computer Viewing Model for Classification of Erythrocytes Infected with Plasmodium spp. Applied to Malaria Diagnosis Using Optical Microscope

Medicina, Год журнала: 2025, Номер 61(5), С. 940 - 940

Опубликована: Май 21, 2025

Background and Objectives: Malaria is a disease that can result in variety of complications. Diagnosis carried out by an optical microscope depends on operator experience. The use artificial intelligence to identify morphological patterns erythrocytes would improve our diagnostic capability. object this study was therefore establish computer viewing models able classify blood cells infected with Plasmodium spp. support malaria diagnosis microscope. Materials Methods: A total 27,558 images human sample extensions were obtained from public data bank for analysis; half parasite-infected red (n = 13,779), the other uninfected 13,779). Six (five machine learning algorithms one pre-trained convolutional neural network) assessed, performance each measured using metrics like accuracy (A), precision (P), recall, F1 score, area under curve (AUC). Results: model best VGG-19, AUC 98%, 93%, 92%, recall 94%, score 93%. Conclusions: Based results, we propose network (VGG-19) be applied low-complexity laboratories thanks its ease implementation high predictive performance.

Язык: Английский

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