Membrane alteration, anti-virulence properties and metabolomic perturbation of a chionodracine-derived antimicrobial peptide, KHS-Cnd, on two bacteria models

Peptides, Год журнала: 2024, Номер unknown, С. 171311 - 171311

Опубликована: Окт. 1, 2024

Язык: Английский

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A systematic overview of strategies for photosensitizer and light delivery in antibacterial photodynamic therapy for lung infections

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 215, С. 115472 - 115472

Опубликована: Ноя. 15, 2024

Язык: Английский

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Hyaluronic acid based nanoparticles that mediate sustained thanatin release protect against NDM-1–resistant bacterial infections in a murine model

Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2024, Номер unknown, С. 102796 - 102796

Опубликована: Ноя. 1, 2024

Язык: Английский

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Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens

Biotechnology Advances, Год журнала: 2024, Номер unknown, С. 108492 - 108492

Опубликована: Дек. 1, 2024

The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, represents a critical global public health challenge. In response, mRNA vaccines offer an adaptable scalable platform for immunotherapy against pathogens by encoding specific antigens that stimulate B-cell-driven antibody production CD8

Язык: Английский

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Breaking the resistance: integrative approaches with novel therapeutics against Klebsiella pneumoniae

Archives of Microbiology, Год журнала: 2024, Номер 207(1)

Опубликована: Дек. 26, 2024

Язык: Английский

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Six-Year Epidemiologic Analysis of Antibiotic Resistance Patterns of Klebsiella pneumoniae Infections in a Tertiary Healthcare Center in Western Romania

Microbiology Research, Год журнала: 2024, Номер 15(4), С. 2661 - 2672

Опубликована: Дек. 12, 2024

Background and Objectives: Klebsiella pneumoniae is a major nosocomial pathogen with remarkable ability to develop resistance multiple antibiotics, posing significant treatment challenges. This study aims evaluate the antimicrobial patterns among multidrug-resistant (MDR) non-MDR strains of K. isolated over six-year period (2018–2023) at Clinical Hospital Infectious Diseases Pulmonology “Dr. Victor Babes” in Timisoara, Romania. The objectives include categorizing isolates based on their antibiotic profiles identifying trends key antibiotics optimize strategies enhance infection control measures. Materials Methods: A cross-sectional analysis was conducted obtained from various clinical samples between January 2018 December 2023. Identification performed using standard bacteriological procedures, susceptibility testing Kirby–Bauer disk diffusion method accordance EUCAST guidelines. Isolates were classified as susceptible, resistant, MDR, extensively drug-resistant (XDR), or pandrug-resistant (PDR) ECDC definitions. Data analyzed GraphPad Prism 6, chi-square tests Cochran–Armitage trend applied where appropriate. Statistical significance set p < 0.05. Results: total 1,081 identified period, increasing 118 319 proportion XDR PDR showed upward 30.5% 57.4% 2023 (p 0.001). Specifically, increased 22.9% 39.8% 2023, while rose 7.6% 17.6%. Among monomicrobial infections accounted for 42.4% 16.5%, respectively. Resistance carbapenems also increase; instance, ertapenem 35.6% 54.2% Subgroup revealed that bronchial aspirates had highest rates 38.0% 17.2%, Additionally, polymicrobial both co-infecting pathogens XDR/PDR 24.2% 46.6% Conclusions: demonstrates escalation particularly strains. rising critical like underscores urgent need enhanced stewardship Targeted interventions are essential curb spread these resistant therapeutic strategies.

Язык: Английский

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Phenotypic and Genotypic Detection of Biofilm Formation of Klebsiella Pneumoniae Clinical Isolates

Infection Epidemiology and Microbiology, Год журнала: 2024, Номер 10(4), С. 277 - 285

Опубликована: Дек. 1, 2024

Язык: Английский

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