International Journal of Newgen Research in Pharmacy & Healthcare,
Год журнала:
2024,
Номер
unknown, С. 142 - 148
Опубликована: Дек. 31, 2024
This
drug
delivery
system
is
designed
to
deliver
a
therapeutic
amount
of
medicine
the
right
place
in
body,
allowing
for
rapid
achievement
and
maintenance
desired
concentrations.
Gels
are
solids
or
semisolids
that
include
at
least
two
substances;
typically,
they
composed
dense
mass
surrounded
permeated
by
liquid.
A
number
chemical
components
present,
including
organic
acids,
flavonoids,
phenolic
acids.
Because
its
anti-inflammatory,
antibacterial,
antioxidant
characteristics,
Vigna
radiata
an
effective
acne
treatment.
Cosmetically
ubiquitous
Aloe
barbadensis
(Aloe
Vera)
has
long
been
known
efficacy
alleviating
skin
conditions
pigmentation,
acne,
burns,
more.
anti-inflammatory
wound-healing
it
useful
ingredient
prescription
treatments.
In
fact,
there
wide
spectrum
medicines
available
treatment
from
conventional
antibiotics
more
contemporary
methods
even
natural
cures.
Mixing
gel
with
ethanolic
extracts
Moringa
oleifera
resulted
improved
carbopol
base;
this
trio
herbal
may
help
reduce
acne.
The
antimicrobial
inquiry
did
not
find
any
signs
microbial
contamination
zone
inhibition.
vivo
irritation
examination
detect
lesions
such
defatting,
unpleasant
reactions,
local
systemic
alteration.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5021 - 5044
Опубликована: Май 1, 2024
Nanoparticle
systems
integrating
alginate
and
chitosan
emerge
as
a
promising
avenue
to
tackle
challenges
in
leveraging
the
potency
of
pharmacological
active
agents.
Owing
their
intrinsic
properties
polysaccharides,
chitosan,
exhibit
remarkable
biocompatibility,
rendering
them
conducive
bodily
integration.
By
downsizing
drug
particles
nano-scale,
system
enhances
solubility
aqueous
environments
by
augmenting
surface
area.
Additionally,
orchestrates
extended
release
kinetics,
aligning
well
with
exigencies
chronic
requisite
for
antibacterial
therapeutics.
A
thorough
scrutiny
existing
literature
underscores
wealth
evidence
supporting
utilization
alginate-chitosan
nanoparticle
agent
delivery.
Literature
reviews
present
abundant
based
on
combination
Various
experiments
demonstrate
enhanced
efficacy,
including
an
increase
inhibitory
zone
diameter,
improvement
minimum
concentration,
enhancement
bacterial
reduction
rate.
This
efficacy
occurs
due
mechanisms
involving
increased
resulting
from
particle
size
reduction,
prolonged
effects,
selectivity
towards
cell
walls,
stemming
ionic
interactions
between
positively
charged
teichoic
acid
walls.
However,
clinical
studies
remain
limited,
there
are
currently
no
marketed
drugs
utilizing
this
system.
Hence,
expediting
validation
is
crucial
maximize
its
benefits
promptly.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
493, С. 152445 - 152445
Опубликована: Май 21, 2024
With
the
increasing
demand
for
tissue
adhesive,
soft
self-healing,
antifouling,
biodegradable
and
biocompatible
biosensors,
use
of
biomimetic
polymers
has
paved
way
development
these
advanced
sensing
systems.
Especially,
have
provided
new
opportunities
directions
implantable
wearable
biosensors.
In
fact,
impressive
in
bio-inspired
composites
based
on
led
to
creation
tissue-adhesive
biosensors
with
minimal
immune
response
or
biofouling.
This
review
aims
cover
advances
mimetic
(natural
synthetic)
an
emphasis
state-of-the-art
devices
composites.
It
also
highlights
unique
properties
such
as
self-adhesion,
enzyme-like
activity,
antibacterial
regenerative
etc.
Considering
high
rate
cancer
world,
especially
developing
countries,
a
separate
section
is
dedicated
biopolymers-based
sensors
early
diagnosis
cancer.
Finally,
outlook
current
challenges
future
developments
this
field
presented.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 8091 - 8113
Опубликована: Авг. 1, 2024
The
current
treatments
for
wound
healing
still
exhibit
drawbacks
due
to
limited
availability
at
the
action
sites,
susceptibility
degradation,
and
immediate
drug
release,
all
of
which
are
detrimental
in
chronic
conditions.
Nano-modification
strategies,
offering
various
advantages
that
can
enhance
physicochemical
properties
drugs,
have
been
employed
efforts
maximize
efficacy
medications.
Nowadays,
nanostructured
lipid
carriers
(NLCs)
provide
delivery
capabilities
safeguard
active
compounds
from
environmental
influences
enable
controlled
release
profiles.
Consequently,
NLCs
considered
an
alternative
therapy
address
challenges
encountered
treatment.
This
review
delves
into
application
healing,
encompassing
discussions
on
their
composition,
preparation
methods,
impact
treatment
effectiveness.
modification
drugs
NLC
model
be
facilitated
using
relatively
straightforward
technologies
such
as
pressure-based
processes,
emulsification
techniques,
solvent
utilization
or
phase
inversion.
Moreover,
production
with
minimal
material
compositions
accommodate
both
single
combination
delivery.
Through
vitro,
vivo,
clinical
studies,
it
has
substantiated
therapeutic
potential
types
treatments.
by
reducing
substance
particle
size,
increasing
solubility
bioavailability,
prolonging
ensuring
sustained
dosage
site
wounds.
In
summary,
represent
effective
nanocarrier
system
optimizing
bioavailability
pharmacological
ingredients
context
healing.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 3, 2025
The
global
crisis
of
antimicrobial
resistance
(AMR)
is
escalating
due
to
the
misuse
and
overuse
antibiotics,
slow
development
new
therapies,
rise
multidrug-resistant
(MDR)
infections.
Traditional
antibiotic
treatments
face
limitations,
including
resistance,
disruption
microbiota,
adverse
side
effects,
environmental
impact,
emphasizing
urgent
need
for
innovative
alternative
antibacterial
strategies.
This
review
critically
examines
naturally
derived
biopolymers
with
intrinsic
(essential
feature)
properties
as
a
sustainable,
next-generation
traditional
antibiotics.
These
may
address
bacterial
uniquely
by
disrupting
membranes
rather
than
cellular
functions,
potentially
reducing
microbiota
interference.
Through
comparative
analysis
mechanisms
applications
antibiotics
biopolymers,
this
highlights
potential
such
AMR
while
supporting
human
health.
International Journal of Applied Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 206 - 213
Опубликована: Май 7, 2025
Objective:
This
study
aimed
to
formulate
and
evaluate
the
antibacterial
activity
of
a
nanogel
preparation
incorporating
Bangkal
(Nauclea
subdita)
bark
extract
against
Propionibacterium
acnes.
Methods:
was
obtained
using
maceration
technique
with
70%
ethanol
as
solvent
(1:10).
The
resulting
thick
then
formulated
into
subjected
stability
testing.
Antibacterial
assessed
well
diffusion
method.
formulation
exhibiting
highest
inhibition
zone
underwent
particle
size
analysis
Particle
Size
Analyzer
(PSA).
extracted
made
nanogels,
tests
were
carried
out,
its
tested
will
have
identified
Results:
successfully
homogenous,
brown
gel
characteristic
aroma.
PSA
revealed
nanoparticle
0.995
nm.
assay
showed
effective
P.
acnes,
zones
ranging
from
6
8
mm.
F3
(8%
extract)
exhibited
an
mm
zone.
Conclusion:
demonstrates
potential
extracts
in
for
acne
treatment.
moderate
activity,
suggesting
viability
natural
alternative
management.
Ethanol
green
supports
sustainable
eco-friendly
development.
Polymers,
Год журнала:
2024,
Номер
17(1), С. 18 - 18
Опубликована: Дек. 25, 2024
The
grapevine
industry
is
confronted
with
challenges
such
as
plant
stress
from
environmental
factors
and
microbial
infections,
alongside
the
need
for
sustainable
waste
management
practices.
Natural
polymers
offer
promising
solutions
to
these
issues
due
their
biocompatibility,
biodegradability,
functional
versatility.
This
review
explores
dual
role
of
natural
in
enhancing
industry:
protective
agents
against
various
stressors
carriers
delivery
valuable
compounds
recovered
wastes.
We
examine
use
chitosan,
alginate,
cellulose
formulating
bio-based
coatings
treatments
that
bolster
resistance
abiotic
stress,
pathogens,
pests.
Additionally,
delves
into
innovative
utilization
residues,
including
skins,
seeds,
stems,
sources
polyphenols
other
bioactive
compounds.
These
can
be
efficiently
encapsulated
polymer
matrices
applications
agriculture,
food,
pharmaceuticals.
Key
topics
include
mechanisms
action,
benefits,
limitations
polymer-based
interventions,
well
case
studies
demonstrating
practical
implementation
vineyards.
also
addresses
future
research
directions,
emphasizing
integrated
approaches
enhance
sustainability
economic
viability
industry.
