Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.
Язык: Английский
Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.
Язык: Английский
Процитировано
7
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 29, 2025
Skin wound healing is a complex physiological process that involves many different cell types and signaling molecules. In traditional Chinese medicine, A. membranaceus Panax notoginseng are commonly used together for the treatment of injury their significant efficacy. The application new materials may make -P. (AP) play better curative effect. this study, we fabricated Carboxymethyl chitosan-Sodium alginate hydrogel loaded with extract Astragalus - P. (APCS), which showed favorable stability, biocompatibility, ability to rapidly release drugs. Cell culture experiments demonstrated APCS dramatically increased fibroblast proliferation, migration, differentiation into myofibroblast. vivo on SD rats hydrogels significantly accelerated skin healing, reduced inflammatory response, enhanced formation blood vessels, granulation tissues, collagen fibers, promoted re-epithelialization at site. Increased expression catalase, VEGF, PGP9.5 tissue indicated inhibited oxidative stress vascular neuronal regeneration. summary, displayed great potential as dressing achieving satisfactory full-thickness wounds.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 928 - 928
Опубликована: Янв. 23, 2025
This study explores the metabolic profile and wound-healing capabilities of Ficus trijuja, a species within Moraceae family, for first time. plants contain variety secondary metabolites such as flavonoids, triterpenoids, alkaloids, known their antioxidant, anti-inflammatory, cytotoxic properties. Previous studies demonstrated effectiveness extracts in wound healing, with evidence improved contraction, strength, faster epithelization. shows impact F. trijuja extract gel base well when delivered through lipid nanocapsules (LNCs) formula, on all phases rats, by determining expression levels key markers. The results indicated that treatment accelerated particularly applied nanocapsulation, which comparable efficacy to standard treatments like MEBO® approximately 2.62% improvement healing compared itself. Understanding these molecular markers offers insights developing targeted therapies optimize prevent complication development. To unravel phytochemical composition extract, LC-HRESIMS analysis was implemented, revealed 24 belonging different classes terpenoids, megastigmane. In conclusion, both its nanoformulation have proven vivo can be further investigated potential clinical use.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер 678, С. 125687 - 125687
Опубликована: Май 9, 2025
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 14, 2024
Abstract Management of hard‐to‐heal wounds often requires specialized care that surpasses the capabilities conventional treatments. Even most advanced commercial products lack functionality to meet needs wounds, especially those complicated by active infection, extreme bleeding, and chronic inflammation. The review explores how supramolecular nanovesicles nanoparticles—such as dendrimers, micelles, polymersomes, lipid‐based nanocarriers—can be key introducing wound healing monitoring properties address complex wounds. Their potential enable functions essential for next‐generation products—such hemostatic functions, transdermal penetration, macrophage polarization, targeted delivery, controlled release pharmaceutical ingredients (antibiotics, gaseous products, anti‐inflammatory drugs, growth factors)—is discussed via an extensive overview recent reports. These studies highlight integration systems in is crucial advancing toward a new generation addressing significant gaps current management practices. Current strategies improvements regarding personalized therapies, promising critically evaluated but underexplored polymer‐based nanovesicles, including polymersomes proteinosomes, healing.
Язык: Английский
Процитировано
2
International Journal of Pharmaceutics X, Год журнала: 2024, Номер 8, С. 100285 - 100285
Опубликована: Сен. 15, 2024
Язык: Английский
Процитировано
1
Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.
Язык: Английский
Процитировано
0