Targeting ROS in cancer: rationale and strategies

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 23(8), С. 583 - 606

Опубликована: Июль 9, 2024

Язык: Английский

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Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

International Journal of Nanomedicine, Год журнала: 2022, Номер Volume 17, С. 6427 - 6446

Опубликована: Дек. 1, 2022

Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.

Язык: Английский

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Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(24)

Опубликована: Апрель 26, 2023

Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and low toxicity side effects, has been widely used in the clinical various tumors, especially superficial tumors. However, tumor microenvironment (TME) presents hypoxia due to oxygen (O2 ) supply caused by abnormal vascularization neoplastic tissues O2 consumption induced rapid proliferation cells. The efficacy oxygen-consumping PDT can be hampered a hypoxic TME. To address this problem, researchers have developing advanced nanoplatforms strategies enhance therapeutic effect treatment. This review summarizes recent against TME, thus enhancing efficacy, including increasing content TME through delivering tumors situ generations ; decreasing during design type I photosensitizers. Moreover, synergistically combined other methods such as chemotherapy, photothermal therapy, immunotherapy, gas is accounted for addressing challenging problems mono environments, resistance, proliferation, metastasis. Finally, perspectives opportunities challenges future research translations are provided.

Язык: Английский

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Nanomaterials for photothermal cancer therapy

RSC Advances, Год журнала: 2023, Номер 13(21), С. 14443 - 14460

Опубликована: Янв. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Язык: Английский

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Bibliometric Analysis of Global Research on Cancer Photodynamic Therapy: Focus on Nano-Related Research

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Июнь 16, 2022

A growing body of research has illuminated that photodynamic therapy (PDT) serves as an important therapeutic strategy in oncology and become a hot topic recent years. Although numerous papers related to cancer PDT (CPDT) have been published, no bibliometric studies conducted summarize the landscape, highlight trends hotspots this field. This study collected 5,804 records on CPDT published between 2000 2021 from Web Science Core Collection. Bibliometric analysis visualization were using VOSviewer, CiteSpace, one online platform. The annual publication citation results revealed significant increasing over past 22 China United States, contributing 56.24% total publications, main driving force Chinese Academy Sciences was most prolific institution. Photodiagnosis Photodynamic Therapy Photochemistry Photobiology productive co-cited journals, respectively. All keywords categorized into four clusters including nanomaterial technology, clinical applications, mechanism, photosensitizers. "nanotech-based PDT" "enhanced current hotspots. In addition several nano-related topics such "nanosphere," "nanoparticle," "nanomaterial," "nanoplatform," "nanomedicine" "gold nanoparticle," following "photothermal therapy," "metal organic framework," "checkpoint blockade," "tumor microenvironment," "prodrug" also deserve further attention near future.

Язык: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472

Опубликована: Июнь 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Язык: Английский

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Sonodynamic therapy combined with phototherapy: Novel synergistic strategy with superior efficacy for antitumor and antiinfection therapy

Journal of Controlled Release, Год журнала: 2023, Номер 359, С. 188 - 205

Опубликована: Июнь 8, 2023

Язык: Английский

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Copper and Copper Complexes in Tumor Therapy

ChemMedChem, Год журнала: 2024, Номер 19(11)

Опубликована: Март 6, 2024

Copper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential maintaining homeostasis, as imbalances can lead to toxicity cell death. development drugs that target homeostasis emerged promising strategy anticancer treatment, with particular focus on chelators, ionophores, novel complexes. Recent research also investigated the complexes therapy.

Язык: Английский

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Cancer Nanovaccines: Nanomaterials and Clinical Perspectives

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Май 1, 2024

Abstract Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art nanovaccine development, elucidating innovative strategies and technologies employed their design. It explores both preclinical clinical advancements, emphasizing key studies demonstrating potential elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, impact of nanoscale properties on performance. Detailed insights into complex interplay between tumor microenvironment responses are provided, highlighting challenges opportunities optimizing therapeutic outcomes. Additionally, presents thorough analysis ongoing trials, presenting snapshot landscape. By curating latest scientific findings developments, this aims serve as comprehensive resource researchers clinicians engaged advancing immunotherapy. Integrating design holds immense promise revolutionizing treatment paradigms, provides timely update evolving landscape nanovaccines.

Язык: Английский

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Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia

Small, Год журнала: 2024, Номер 20(26)

Опубликована: Янв. 14, 2024

Abstract Ferroptosis, a novel form of nonapoptotic cell death, can effectively enhance photodynamic therapy (PDT) performance by disrupting intracellular redox homeostasis and promoting apoptosis. However, the extremely hypoxic tumor microenvironment (TME) together with highly expressed hypoxia‐inducible factor‐1α (HIF‐1α) presents considerable challenge for clinical PDT against osteosarcoma (OS). Hence, an innovative nanoplatform that enhances antitumor inducing ferroptosis alleviating hypoxia is fabricated. Capsaicin (CAP) widely reported to specifically activate transient receptor potential vanilloid 1 (TRPV1) channel, trigger increase in Ca 2+ concentration, which closely linked ferroptosis, participate decreased oxygen consumption inhibiting HIF‐1α cells, potentiating efficiency. Thus, CAP photosensitizer IR780 are coencapsulated into biocompatible human serum albumin (HSA) construct (CI@HSA NPs) synergistic treatment under near‐infrared (NIR) irradiation. Furthermore, underlying signaling pathways combination investigated. CI@HSA NPs achieve real‐time dynamic distribution monitoring exhibit excellent efficacy superior biosafety vivo. Overall, this work highlights promising NIR imaging‐guided “pro‐death” strategy overcome limitations OS hypoxia, providing inspiration support future approaches.

Язык: Английский

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