Materials & Design,
Год журнала:
2023,
Номер
233, С. 112231 - 112231
Опубликована: Авг. 9, 2023
Bacterial
infection
continues
to
be
one
of
the
biggest
threats
human
health.
The
therapeutic
effect
is
significantly
reduced
as
a
result
development
super-bacteria-resistant
bacteria
due
overuse
antibiotics
for
conventional
antimicrobial
treatment.
emergence
drug-resistant
makes
it
necessary
develop
new
treatments.
Following
successful
application
photothermal
therapy
in
field
oncology
treatment,
more
and
researchers
are
applying
treatments
achieving
important
results,
especially
treatment
bacterial
infections.
As
non-invasive
anti-infection
method,
has
advantages
broad-spectrum
properties,
short
period,
low
systemic
impact.
In
PTT,
efficacy
strongly
depends
on
different
laser
properties
choice
agents
(PTAs).
purpose
this
review
discuss
most
recent
developments
nanomaterials
that
antibacterial.
We
will
delve
into
principles
spectrum
PTAs
provide
summary
current
synthesis,
classification,
structural
features,
physicochemical
antibacterial
performance
research.
challenges
future
prospects
enhanced
cytotoxicity
investigated.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 6, 2024
Abstract
The
quest
for
effective
and
reliable
methods
of
delivering
medications,
with
the
aim
improving
delivery
therapeutic
agent
to
intended
location,
has
presented
a
demanding
yet
captivating
field
in
biomedical
research.
concept
smart
drug
systems
is
an
evolving
approach,
serving
as
model
directing
drugs
specific
targets
or
sites.
These
have
been
developed
specifically
target
regulate
administration
substances
diverse
array
chronic
conditions,
including
periodontitis,
diabetes,
cardiac
diseases,
inflammatory
bowel
rheumatoid
arthritis,
different
cancers.
Nevertheless,
numerous
comprehensive
clinical
trials
are
still
required
ascertain
both
immediate
enduring
impacts
such
nanosystems
on
human
subjects.
This
review
delves
into
benefits
vehicles,
aiming
enhance
comprehension
their
applicability
addressing
present
medical
requirements.
Additionally,
it
touches
upon
current
applications
these
stimuli‐reactive
biomedicine
outlines
future
development
prospects.
Journal of Materials Chemistry C,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Based
on
the
understanding
of
photothermal
catalysis,
this
review
summarizes
recent
progress
CeO
2
-based
multicomponent
catalysts
for
catalytic
CO
reduction.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
ACS Nano,
Год журнала:
2023,
Номер
17(18), С. 18318 - 18331
Опубликована: Сен. 10, 2023
Malignant
melanoma,
as
a
highly
aggressive
skin
cancer,
is
strongly
associated
with
mutations
in
serine/threonine
protein
kinase
B-RAF
(BRAF,
where
RAF
stands
for
rapidly
accelerated
fibrosarcoma).
Targeted
therapy
anti-BRAF
small
interfering
RNA
(siBRAF)
represents
crucial
aspect
of
metastatic
melanoma
treatment.
In
this
study,
an
injectable
hydrogel
platform
based
on
sodium
alginate
(SA),
multifunctions
photothermal
and
Ca2+-overload
cell
apoptosis,
was
explored
siBRAF
carrier
therapy.
We
employed
polydopamine
nanoparticles
(PDAs)
core
constructed
calcium
phosphate
(CaP)
shell
via
biomineralization
(PDA@CaP)
to
load
(PDA@siBRAF/CaP).
The
pH-sensitive
CaP
facilitated
the
release
Ca2+
under
weakly
acidic
tumor
microenvironment,
triggering
gelation
PDA@siBRAF/CaP-SA
localized
at
sites
interruption
RAS-RAF-MEK-ERK
(MAPK)
pathway.
Besides,
continuous
could
also
lead
apoptosis.
Moreover,
effect
PDA
regulated
kinetics,
resulting
coordinated
therapeutic
abilities
individual
components
hydrogels.
Consequently,
effective
inhibition
growth
metastasis
achieved
vitro
vivo
using
line
B16F10
model,
by
combining
ablation,
overload,
BRAF
silencing.
Our
work
provides
proof-of-concept
system
that
simultaneously
targets
multiple
mechanisms
involved
progression
has
potential
be
translated
into
clinical
use
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 376 - 412
Опубликована: Март 21, 2024
The
treatment
of
digestive
system
tumors
presents
challenges,
particularly
in
immunotherapy,
owing
to
the
advanced
immune
tolerance
system.
Nanomaterials
have
emerged
as
a
promising
approach
for
addressing
these
challenges.
They
provide
targeted
drug
delivery,
enhanced
permeability,
high
bioavailability,
and
low
toxicity.
Additionally,
nanomaterials
target
immunosuppressive
cells
reshape
tumor
microenvironment
(TIME).
Among
various
TIME,
tumor-associated
macrophages
(TAMs)
are
most
abundant
play
crucial
role
progression.
Therefore,
investigating
modulation
TAMs
by
is
great
significance.
Here,
we
present
comprehensive
review
utilization
modulate
gastric
cancer,
colorectal
hepatocellular
carcinoma,
pancreatic
cancer.
We
also
investigated
underlying
mechanisms
which
treat
Furthermore,
this
summarizes
macrophage-derived
tumors.
Overall,
research
offers
valuable
insights
into
development
tailored
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43302 - 43316
Опубликована: Авг. 7, 2024
Photothermal
therapy
(PTT)
is
a
method
for
eradicating
tumor
tissues
through
the
use
of
photothermal
materials
and
photosensitizing
agents
that
absorb
light
energy
from
laser
sources
convert
it
into
heat,
which
selectively
targets
destroys
cancer
cells
while
sparing
healthy
tissue.
MXenes
have
been
intensively
investigated
as
PTT.
However,
achieving
selectivity
to
remains
challenge.
Specific
antibodies
(Ab)
against
antigens
can
achieve
homing
toward
cells,
but
their
immobilization
on
MXene
received
little
attention.
Here,
we
offer
strategy
selective
ablation
melanoma
using
MXene-polydopamine-antiCEACAM1
Ab
complexes.
We
coated
Ti3C2Tx
with
polydopamine
(PDA),
natural
compound
attaches
surface,
followed
by
conjugation
an
anti-CEACAM1
Ab.
Our
experiments
confirm
biocompatibility
Ti3C2Tx-PDA
Ti3C2Tx-PDA-antiCEACAM1
complexes
across
various
cell
types.
also
established
protocol
CEACAM1-positive
near-infrared
irradiation.
The
obtained
exhibit
high
efficiency
in
targeting
eliminating
CEACAM1-negative
cells.
These
results
demonstrate
potential
MXene-PDA-Ab
therapy.
They
underline
critical
role
targeted
therapies
oncology,
offering
promising
avenue
precise
safe
treatment
possibly
other
cancers
characterized
specific
biomarkers.
Future
research
will
aim
refine
these
clinical
use,
paving
way
new
strategies
treatment.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(31)
Опубликована: Авг. 22, 2024
The
prevalence
of
drug-resistant
bacterial
infections
has
emerged
as
a
grave
threat
to
clinical
treatment
and
global
human
health,
presenting
one
the
foremost
challenges
in
medical
care.
Thus,
there
is
an
urgent
imperative
develop
safe
efficacious
novel
antimicrobial
strategies.
Nitric
oxide
(NO)
recognized
endogenous
signaling
molecule,
which
plays
pivotal
role
numerous
pathological
processes.
Currently,
NO
garnered
significant
interest
antibacterial
agent
due
its
capability
eradicate
bacteria,
disrupt
biofilms,
facilitate
wound
healing,
all
while
circumventing
emergence
drug
resistance.
However,
inherently
unstable
characteristic
therapeutic
gas
renders
controlled
administration
gases
exceedingly
challenging.
Hence,
this
review,
current
challenge
infection
discussed;
then
it
briefly
elucidated
mechanism
comprehensively
delineate
recent
advancements
stimulus-responsive
delivery
platforms,
along
with
their
merits,
obstacles,
prospective
avenues
for
application.
This
review
offers
guidance
future
NO-medicated
anti-infection
therapy
hoped.
