Nanomaterials,
Год журнала:
2021,
Номер
11(10), С. 2525 - 2525
Опубликована: Сен. 27, 2021
Carbon
dots
(CDs)
are
usually
smaller
than
10
nm
in
size,
and
meticulously
formulated
recently
introduced
nanomaterials,
among
the
other
types
of
carbon-based
nanomaterials.
They
have
gained
significant
attention
an
incredible
interest
field
nanotechnology
biomedical
science,
which
is
merely
due
to
their
considerable
exclusive
attributes;
including
enhanced
electron
transferability,
photobleaching
photo-blinking
effects,
high
photoluminescent
quantum
yield,
fluorescence
property,
resistance
photo-decomposition,
increased
electrocatalytic
activity,
good
aqueous
solubility,
excellent
biocompatibility,
long-term
chemical
stability,
cost-effectiveness,
negligible
toxicity,
acquaintance
large
effective
surface
area-to-volume
ratio.
CDs
can
be
readily
functionalized
owing
abundant
functional
groups
on
surfaces,
they
also
exhibit
remarkable
sensing
features
such
as
specific,
selective,
multiplex
detectability.
In
addition,
physico-chemical
characteristics
easily
tunable
based
intended
usage
or
application.
this
comprehensive
review
article,
we
mainly
discuss
classification
CDs,
ideal
properties,
general
synthesis
approaches,
primary
characterization
techniques.
More
importantly,
update
readers
about
recent
trends
health
care
applications
(viz.,
substantial
prominent
role
area
electrochemical
optical
biosensing,
bioimaging,
drug/gene
delivery,
well
photodynamic/photothermal
therapy).
Nanomaterials,
Год журнала:
2022,
Номер
12(13), С. 2140 - 2140
Опубликована: Июнь 22, 2022
Neurological
disorders
(NDs)
are
recognized
as
one
of
the
major
health
concerns
globally.
According
to
World
Health
Organization
(WHO),
neurological
main
causes
mortality
worldwide.
include
Alzheimer’s
disease,
Parkinson′s
Huntington′s
Amyotrophic
lateral
sclerosis,
Frontotemporal
dementia,
Prion
Brain
tumor,
Spinal
cord
injury,
and
Stroke.
These
diseases
considered
incurable
because
no
specific
therapies
available
cross
blood-brain
barrier
(BBB)
reach
brain
in
a
significant
amount
for
pharmacological
effect
brain.
There
is
need
development
strategies
that
can
improve
efficacy
drugs
circumvent
BBB.
One
promising
approaches
use
different
types
nano-scale
materials.
nano-based
have
ability
increase
therapeutic
effect,
reduce
toxicity,
exhibit
good
stability,
targeted
delivery,
drug
loading
capacity.
Different
shapes
nanomaterials
been
widely
used
treatment
disorders,
including
quantum
dots,
dendrimers,
metallic
nanoparticles,
polymeric
carbon
nanotubes,
liposomes,
micelles.
nanoparticles
unique
characteristics,
sensitivity,
selectivity,
BBB
when
nano-sized
particles,
imaging
studies
NDs.
In
this
review,
we
briefly
summarized
recent
literature
on
various
their
mechanism
action
disorders.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 23, 2024
Abstract
Background
Therapeutic
strategies
based
on
scavenging
reactive
oxygen
species
(ROS)
and
suppressing
inflammatory
cascades
are
effective
in
improving
functional
recovery
after
spinal
cord
injury
(SCI).
However,
the
lack
of
targeting
nanoparticles
(NPs)
with
powerful
antioxidant
anti-inflammatory
properties
hampers
clinical
translation
these
strategies.
Here,
CD44-targeting
hyaluronic
acid-selenium
(HA-Se)
NPs
were
designed
prepared
for
ROS
responses
injured
cord,
enhancing
recovery.
Results
The
HA-Se
easily
through
direct
reduction
seleninic
acid
presence
HA.
obtained
exhibited
a
remarkable
capacity
to
eliminate
free
radicals
CD44
receptor-facilitated
internalization
by
astrocytes.
Moreover,
effectively
mitigated
secretion
proinflammatory
cytokines
(such
as
IL-1β,
TNF-α,
IL-6)
microglia
cells
(BV2)
upon
lipopolysaccharide-induced
inflammation.
In
vivo
experiments
confirmed
that
could
accumulate
within
lesion
site
targeting.
As
result,
demonstrated
superior
protection
axons
neurons
site,
leading
enhanced
rat
model
SCI.
Conclusions
These
results
highlight
potential
SCI
treatment.
Advanced Functional Materials,
Год журнала:
2021,
Номер
32(13)
Опубликована: Дек. 1, 2021
Abstract
Spinal
cord
injury
(SCI)
often
leads
to
the
loss
of
motor
and
sensory
functions
is
a
major
challenge
in
neurological
clinical
practice.
Understanding
pathophysiological
changes
inhibitory
microenvironment
crucial
enable
identification
potential
mechanisms
for
functional
restoration
provide
guidance
development
efficient
treatment
repair
strategies.
To
date,
implantation
specifically
functionalized
biomaterials
lesion
area
has
been
shown
help
promote
axon
regeneration
facilitate
neuronal
circuit
generation
by
remolding
SCI
microenvironments.
Moreover,
structural
spinal
through
transplantation
naive
tissue
grafts
from
adult
donors,
artificial
cord‐like
developed
engineering,
3D
printing
will
open
up
new
avenues
treatment.
This
review
focuses
on
dynamic
microenvironments,
repairs,
strategies
restoring
structure
function,
experimental
animal
models,
regenerative
mechanisms,
studies
repair.
The
current
status,
recent
advances,
challenges,
prospects
scaffold‐based
basic
settings
are
summarized
discussed,
reference
that
guide
future
exploration
Theranostics,
Год журнала:
2023,
Номер
13(12), С. 3966 - 3987
Опубликована: Янв. 1, 2023
Traumatic
spinal
cord
injury
(SCI)
can
cause
severe
neurological
impairments.Clinically
available
treatments
are
quite
limited,
with
unsatisfactory
remediation
effects.Residing
endogenous
neural
stem/progenitor
cells
(eNSPCs)
tend
to
differentiate
towards
astrocytes,
leaving
only
a
small
fraction
oligodendrocytes
and
even
fewer
neurons;
this
has
been
suggested
as
one
of
the
reasons
for
failure
autonomous
neuronal
regeneration.Thus,
finding
ways
recruit
facilitate
differentiation
eNSPCs
neurons
considered
promising
strategy
noninvasive
immune-compatible
treatment
SCI.The
present
manuscript
first
introduces
responses
after
exogenous
interventions
boost
neurogenesis
in
various
SCI
models.Then,
we
focus
on
state-of-art
manipulation
approaches
that
enhance
intrinsic
capacity
reconstruct
hostile
microenvironment,
mainly
consisting
pharmacological
treatments,
stem
cell-derived
exosome
administration,
gene
therapy,
functional
scaffold
implantation,
inflammation
regulation,
inhibitory
element
delineation.Facing
extremely
complex
situation
SCI,
combined
also
highlighted
provide
more
clues
future
relevant
investigations.
Abstract
Cisplatin‐associated
acute
kidney
injury
(AKI)
is
a
severe
clinical
syndrome
that
significantly
restricts
the
chemotherapeutic
application
of
cisplatin
in
cancer
patients.
Ferroptosis,
newly
characterized
programmed
cell
death
driven
by
lethal
accumulation
lipid
peroxidation,
widely
reported
to
be
involved
pathogenesis
cisplatin‐associated
AKI.
Targeted
inhibition
ferroptosis
holds
great
promise
for
developing
novel
therapeutics
alleviate
Unfortunately,
current
inhibitors
possess
low
bioavailability
or
perform
non‐specific
body,
making
them
inefficient
alleviating
AKI
inadvertently
reducing
anti‐tumor
efficacy
cisplatin,
thus
not
suitable
application.
In
this
study,
selenium
nanomaterial,
polyacrylic
acid‐coated
selenium‐doped
carbon
dots
(SeCD),
rationally
developed.
SeCD
exhibits
high
biocompatibility
and
specifically
accumulates
kidney.
Administration
effectively
scavenges
broad‐spectrum
reactive
oxygen
species
facilitates
GPX4
expression
releasing
selenium,
resulting
strong
mitigation
renal
tubular
epithelial
cells
substantial
alleviation
AKI,
without
compromising
cisplatin.
This
study
highlights
promising
therapeutic
approach
prevention
patients
undergoing
chemotherapy.
