Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(10), P. 2525 - 2525

Published: Sept. 27, 2021

Carbon dots (CDs) are usually smaller than 10 nm in size, and meticulously formulated recently introduced nanomaterials, among the other types of carbon-based nanomaterials. They have gained significant attention an incredible interest field nanotechnology biomedical science, which is merely due to their considerable exclusive attributes; including enhanced electron transferability, photobleaching photo-blinking effects, high photoluminescent quantum yield, fluorescence property, resistance photo-decomposition, increased electrocatalytic activity, good aqueous solubility, excellent biocompatibility, long-term chemical stability, cost-effectiveness, negligible toxicity, acquaintance large effective surface area-to-volume ratio. CDs can be readily functionalized owing abundant functional groups on surfaces, they also exhibit remarkable sensing features such as specific, selective, multiplex detectability. In addition, physico-chemical characteristics easily tunable based intended usage or application. this comprehensive review article, we mainly discuss classification CDs, ideal properties, general synthesis approaches, primary characterization techniques. More importantly, update readers about recent trends health care applications (viz., substantial prominent role area electrochemical optical biosensing, bioimaging, drug/gene delivery, well photodynamic/photothermal therapy).

Language: Английский

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Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2140 - 2140

Published: June 22, 2022

Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to World Health Organization (WHO), neurological main causes mortality worldwide. include Alzheimer’s disease, Parkinson′s Huntington′s Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion Brain tumor, Spinal cord injury, and Stroke. These diseases considered incurable because no specific therapies available cross blood-brain barrier (BBB) reach brain in a significant amount for pharmacological effect brain. There is need development strategies that can improve efficacy drugs circumvent BBB. One promising approaches use different types nano-scale materials. nano-based have ability increase therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, drug loading capacity. Different shapes nanomaterials been widely used treatment disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. nanoparticles unique characteristics, sensitivity, selectivity, BBB when nano-sized particles, imaging studies NDs. In this review, we briefly summarized recent literature on various their mechanism action disorders.

Language: Английский

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CD44-targeting hyaluronic acid-selenium nanoparticles boost functional recovery following spinal cord injury

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 23, 2024

Abstract Background Therapeutic strategies based on scavenging reactive oxygen species (ROS) and suppressing inflammatory cascades are effective in improving functional recovery after spinal cord injury (SCI). However, the lack of targeting nanoparticles (NPs) with powerful antioxidant anti-inflammatory properties hampers clinical translation these strategies. Here, CD44-targeting hyaluronic acid-selenium (HA-Se) NPs were designed prepared for ROS responses injured cord, enhancing recovery. Results The HA-Se easily through direct reduction seleninic acid presence HA. obtained exhibited a remarkable capacity to eliminate free radicals CD44 receptor-facilitated internalization by astrocytes. Moreover, effectively mitigated secretion proinflammatory cytokines (such as IL-1β, TNF-α, IL-6) microglia cells (BV2) upon lipopolysaccharide-induced inflammation. In vivo experiments confirmed that could accumulate within lesion site targeting. As result, demonstrated superior protection axons neurons site, leading enhanced rat model SCI. Conclusions These results highlight potential SCI treatment.

Language: Английский

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Selective electrochemical sensing of dopamine via solid-state hydrothermal β-cyclodextrin-functionalized selenium quantum dots-embedded with multiwall carbon nanotubes

Applied Surface Science, Journal Year: 2025, Volume and Issue: 687, P. 162275 - 162275

Published: Jan. 2, 2025

Language: Английский

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Characterization of carbon quantum dots doped with various heteroatoms and their influence on inhibiting the browning of fresh-cut potatoes

Food Packaging and Shelf Life, Journal Year: 2025, Volume and Issue: 47, P. 101440 - 101440

Published: Jan. 1, 2025

Language: Английский

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Advances in Biomaterial‐Based Spinal Cord Injury Repair

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(13)

Published: Dec. 1, 2021

Abstract Spinal cord injury (SCI) often leads to the loss of motor and sensory functions is a major challenge in neurological clinical practice. Understanding pathophysiological changes inhibitory microenvironment crucial enable identification potential mechanisms for functional restoration provide guidance development efficient treatment repair strategies. To date, implantation specifically functionalized biomaterials lesion area has been shown help promote axon regeneration facilitate neuronal circuit generation by remolding SCI microenvironments. Moreover, structural spinal through transplantation naive tissue grafts from adult donors, artificial cord‐like developed engineering, 3D printing will open up new avenues treatment. This review focuses on dynamic microenvironments, repairs, strategies restoring structure function, experimental animal models, regenerative mechanisms, studies repair. The current status, recent advances, challenges, prospects scaffold‐based basic settings are summarized discussed, reference that guide future exploration

Language: Английский

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Carbon quantum dots as ROS-generator and -scavenger: A comprehensive review

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 208, P. 110784 - 110784

Published: Sept. 26, 2022

Language: Английский

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Recent advances in endogenous neural stem/progenitor cell manipulation for spinal cord injury repair

Theranostics, Journal Year: 2023, Volume and Issue: 13(12), P. 3966 - 3987

Published: Jan. 1, 2023

Traumatic spinal cord injury (SCI) can cause severe neurological impairments.Clinically available treatments are quite limited, with unsatisfactory remediation effects.Residing endogenous neural stem/progenitor cells (eNSPCs) tend to differentiate towards astrocytes, leaving only a small fraction oligodendrocytes and even fewer neurons; this has been suggested as one of the reasons for failure autonomous neuronal regeneration.Thus, finding ways recruit facilitate differentiation eNSPCs neurons considered promising strategy noninvasive immune-compatible treatment SCI.The present manuscript first introduces responses after exogenous interventions boost neurogenesis in various SCI models.Then, we focus on state-of-art manipulation approaches that enhance intrinsic capacity reconstruct hostile microenvironment, mainly consisting pharmacological treatments, stem cell-derived exosome administration, gene therapy, functional scaffold implantation, inflammation regulation, inhibitory element delineation.Facing extremely complex situation SCI, combined also highlighted provide more clues future relevant investigations.

Language: Английский

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A wearable self-powered microneedle system based on conductive drugs for infected wound healing: A new electrical stimulation delivery strategy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 480, P. 148347 - 148347

Published: Dec. 25, 2023

Language: Английский

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Polyacrylic Acid‐Coated Selenium‐Doped Carbon Dots Inhibit Ferroptosis to Alleviate Chemotherapy‐Associated Acute Kidney Injury

Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)

Published: April 30, 2024

Abstract Cisplatin‐associated acute kidney injury (AKI) is a severe clinical syndrome that significantly restricts the chemotherapeutic application of cisplatin in cancer patients. Ferroptosis, newly characterized programmed cell death driven by lethal accumulation lipid peroxidation, widely reported to be involved pathogenesis cisplatin‐associated AKI. Targeted inhibition ferroptosis holds great promise for developing novel therapeutics alleviate Unfortunately, current inhibitors possess low bioavailability or perform non‐specific body, making them inefficient alleviating AKI inadvertently reducing anti‐tumor efficacy cisplatin, thus not suitable application. In this study, selenium nanomaterial, polyacrylic acid‐coated selenium‐doped carbon dots (SeCD), rationally developed. SeCD exhibits high biocompatibility and specifically accumulates kidney. Administration effectively scavenges broad‐spectrum reactive oxygen species facilitates GPX4 expression releasing selenium, resulting strong mitigation renal tubular epithelial cells substantial alleviation AKI, without compromising cisplatin. This study highlights promising therapeutic approach prevention patients undergoing chemotherapy.

Language: Английский

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