Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101820 - 101820
Опубликована: Май 1, 2025
Helicobacter
pylori
is
a
significant
risk
factor
for
gastric
cancer,
making
its
elimination
crucial
prevention.
This
review
explores
the
application
of
nanotechnology
in
enhancing
treatment
efficacy
against
H.
and
addressing
antibiotic
resistance.
Nanomaterials
are
utilized
as
drug
carriers
to
protect
pharmaceuticals
from
acidic
environment
enable
controlled
release.
These
materials
can
be
specifically
engineered
target
surface
molecules,
thereby
improving
antimicrobial
efficacy.
Enhanced
penetration
achieved
by
optimizing
properties
molecular
architecture
nanomaterials.
Additional
strategies
include
targeting
virulence
factors,
such
urease
vacuolating
cytotoxin
A,
well
inhibiting
bacterial
proliferation
through
reactive
oxygen
species-based
therapies.
Moreover,
ability
nanomaterials
effectively
modulate
microbiota
inhibit
pathogens
has
shown
great
potential
combating
pylori.
By
focusing
on
specific
invasion
mechanisms
metabolic
pathways,
offers
promise
advancing
treatments
Despite
potential,
several
challenges
remain,
including
high
development
costs,
difficulties
precise
targeting,
adverse
effects
associated
with
certain
approaches,
photothermal
therapy.
Ongoing
optimization
nanotechnological
anticipated
address
these
challenges,
facilitating
more
effective
targeted
therapies
infection.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 16, 2023
Abstract
Extracellular
vesicles
(EVs)
are
30–150
nm
membrane-bound
naturally
secreted
by
cells
and
play
important
roles
in
intercellular
communication
delivering
regulatory
molecules
such
as
proteins,
lipids,
nucleic
acids
metabolites
to
recipient
cells.
As
natural
nano-carriers,
EVs
possess
desirable
properties
high
biocompatibility,
biological
barrier
permeability,
low
toxicity,
immunogenicity,
making
them
potential
therapeutic
delivery
vehicles.
derived
from
specific
have
inherent
targeting
capacity
towards
cell
types,
which
is
yet
not
satisfactory
enough
for
targeted
therapy
development
needs
be
improved.
Surface
modifications
endow
with
abilities,
significantly
improving
their
efficiency.
Herein,
we
first
briefly
introduce
the
biogenesis,
composition,
uptake
function
of
EVs,
review
cargo
loading
approaches
EVs.
Then,
summarize
recent
advances
surface
engineering
strategies
focusing
on
applications
engineered
therapy.
Altogether,
hold
great
promise
various
cargos,
show
promising
effects
multiple
diseases.
Graphical
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 4751 - 4778
Опубликована: Авг. 1, 2023
Abstract:
Exosomes,
as
natural
nanocarriers,
characterized
with
low
immunogenicity,
non-cytotoxicity
and
targeted
delivery
capability,
which
have
advantages
over
synthetic
nanocarriers.
Recently,
exosomes
shown
great
potential
diagnostic
markers
for
diseases
are
also
considered
a
promising
cell-free
therapy.
Engineered
significantly
enhanced
the
efficacy
precision
of
delivering
therapeutic
agents,
currently
being
extensively
employed
in
investigations
various
ailments,
including
oncology,
inflammatory
disorders,
degenerative
conditions.
Particularly,
engineered
enable
agent
loading,
modification,
evasion
MPS
phagocytosis,
intelligent
control,
bioimaging,
been
developed
multifunctional
nano-delivery
platforms
recent
years.
The
utilization
bioactive
scaffolds
that
loaded
exosome
has
to
substantially
augment
retention,
extend
release,
enhance
efficacy.
This
approach
advanced
from
conventional
hydrogels
nanocomposite
hydrogels,
nanofiber
3D
printing,
resulting
superior
physical
biological
properties
effectively
address
limitations
scaffolds.
Additionally,
plant-derived
exosomes,
can
participate
gut
flora
remodeling
via
oral
administration,
an
ideal
platform
treatment
intestinal
diseases.
Consequently,
there
is
interest
nanocarriers
applications.
comprehensive
review
provides
overview
biogenesis,
composition,
isolation
methods
exosomes.
it
examines
pathological
mechanisms
diseases,
tumors,
Furthermore,
this
highlights
significance
microbial-derived
Strategies
specific
applications
scaffold-loaded
further
summarized,
especially
some
new
techniques
such
large-scale
loading
technique,
macromolecular
development
nano-scaffold-loaded
delivery.
benefits
using
gut-related
discussed.
challenges,
opportunities,
prospects
exosome-based
disease
diagnosis
summarized
both
preclinical
clinical
viewpoints.
Keywords:
diagnosis,
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 126 - 156
Опубликована: Март 2, 2024
Small
extracellular
vesicles
(sEVs)
are
known
to
be
secreted
by
a
vast
majority
of
cells.
These
sEVs,
specifically
exosomes,
induce
specific
cell-to-cell
interactions
and
can
activate
signaling
pathways
in
recipient
cells
through
fusion
or
interaction.
nanovesicles
possess
several
desirable
properties,
making
them
ideal
for
regenerative
medicine
nanomedicine
applications.
properties
include
exceptional
stability,
biocompatibility,
wide
biodistribution,
minimal
immunogenicity.
However,
the
practical
utilization
particularly
clinical
settings
at
large
scale,
is
hindered
expensive
procedures
required
their
isolation,
limited
circulation
lifetime,
suboptimal
targeting
capacity.
Despite
these
challenges,
sEVs
have
demonstrated
remarkable
ability
accommodate
various
cargoes
found
extensive
applications
biomedical
sciences.
To
overcome
limitations
broaden
potential
applications,
researchers
should
strive
deepen
understanding
current
loading,
characterization
techniques.
Additionally,
acquiring
fundamental
knowledge
about
origins
employing
state-of-the-art
methodologies
expand
research
scope.
This
review
provides
comprehensive
overview
exosome-based
strategies
diverse
domains,
encompassing
cancer
therapy,
immunotherapy,
biomarker
Furthermore,
we
emphasize
immense
exosomes
medicine.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 4, 2024
Abstract
Messenger
RNA
(mRNA)
has
emerged
as
a
promising
therapeutic
molecule
with
numerous
clinical
applications
in
treating
central
nervous
system
disorders,
tumors,
COVID-19,
and
other
diseases.
mRNA
therapies
must
be
encapsulated
into
safe,
stable,
effective
delivery
vehicles
to
preserve
the
cargo
from
degradation
prevent
immunogenicity.
Exosomes
have
gained
growing
attention
because
of
their
good
biocompatibility,
low
immunogenicity,
small
size,
unique
capacity
traverse
physiological
barriers,
cell-specific
tropism.
Moreover,
these
exosomes
can
engineered
utilize
natural
carriers
target
specific
cells
or
tissues.
This
targeted
approach
will
enhance
efficacy
reduce
side
effects
mRNAs.
However,
difficulties
such
lack
consistent
reliable
methods
for
exosome
purification
efficient
encapsulation
large
mRNAs
addressed.
article
outlines
current
breakthroughs
cell-derived
vesicle-mediated
its
biomedical
applications.
Graphical
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 1, 2024
Abstract
Inflammatory
bowel
disease
(IBD)
is
closely
linked
to
the
homeostasis
of
intestinal
environment,
and
exosomes
can
be
used
treat
IBD
due
their
high
biocompatibility
ability
effectively
absorbed
by
tract.
However,
Ginseng-derived
nanoparticles
(GDNPs)
have
not
been
studied
in
this
context
mechanism
action
remains
unclear.
Here,
we
investigated
GDNPs
mediate
intercellular
communication
a
complex
inflammatory
microenvironment
order
IBD.
We
found
that
scavenge
reactive
oxygen
species
from
immune
cells
epithelial
cells,
inhibit
expression
pro-inflammatory
factors,
promote
proliferation
differentiation
stem
as
well
enhancing
diversity
flora.
significantly
stabilise
barrier
thereby
promoting
tissue
repair.
Overall,
proved
ameliorate
inflammation
oxidative
stress
vivo
vitro,
acting
on
TLR4/MAPK
p62/Keap1/Nrf2
pathways,
exerting
an
anti-inflammatory
antioxidant
effect.
mitigated
mice
reducing
factors
improving
environment.
This
study
offers
new
evidence
potential
therapeutic
effects
IBD,
providing
conceptual
ground
for
alternative
strategy.
Graphical
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117302 - 117302
Опубликована: Авг. 19, 2024
Inflammatory
bowel
disease
(IBD),
including
Crohn's
and
ulcerative
colitis,
is
a
complex
disorder
with
an
unknown
cause.
However,
the
dysbiosis
of
gut
microbiome
has
been
found
to
play
role
in
IBD
etiology,
exacerbated
immune
responses
defective
intestinal
barrier
integrity.
The
can
also
be
potential
biomarker
for
several
diseases,
IBD.
Currently,
conventional
treatments
targeting
pro-inflammatory
cytokines
pathways
IBD-associated
do
not
yield
effective
results.
Other
therapies
that
directly
target
dysbiotic
outcomes
are
emerging.
We
review
health
its
as
diagnostic,
prognostic,
therapeutic
This
explores
emerging
advancements
microbiome-associated
alterations
IBD,
such
nanoparticle
or
encapsulation
delivery,
fecal
microbiota
transplantation,
nutritional
therapies,
microbiome/probiotic
engineering,
phage
therapy,
mesenchymal
stem
cells
(MSCs),
proteins,
herbal
formulas.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1189 - 1204
Опубликована: Фев. 1, 2024
Abstract:
Tissue
engineering
holds
great
potential
for
tissue
repair
and
rejuvenation.
Plant-derived
exosome-like
nanoparticles
(ELNs)
have
recently
emerged
as
a
promising
avenue
in
engineering.
However,
there
is
an
urgent
need
to
understand
how
plant
ELNs
can
be
therapeutically
applied
clinical
disease
management,
especially
regeneration.
In
this
review,
we
comprehensively
examine
the
properties,
characteristics,
isolation
techniques
of
ELNs.
We
also
discuss
their
impact
on
immune
system,
compatibility
with
human
body,
role
To
ensure
suitability
engineering,
explore
various
modification
strategies.
Additionally,
provide
insights
into
progress
commercialization
industrial
perspectives
This
review
aims
highlight
regenerative
medicine
by
exploring
current
research
landscape
key
findings.
Keywords:
plant,
nanoparticles,
nanomedicine,
cartilage,
wound,
bone
Bacteria
form
a
highly
complex
ecosystem
in
the
gastrointestinal
(GI)
tract.
In
recent
years,
mounting
evidence
has
shown
that
bacteria
can
release
nanoscale
phospholipid
bilayer
particles
encapsulate
nucleic
acids,
proteins,
lipids,
and
other
molecules.
Extracellular
vesicles
(EVs)
are
secreted
by
microorganisms
transport
variety
of
important
factors,
such
as
virulence
antibiotics,
HGT,
defensive
factors
produced
host
eukaryotic
cells.
addition,
these
EVs
vital
facilitating
communication
between
microbiota
host.
Therefore,
bacterial
play
crucial
role
maintaining
GI
tract's
health
proper
functioning.
this
review,
we
outlined
structure
composition
EVs.
Additionally,
highlighted
critical
immune
regulation
balance
gut
microbiota.
To
further
elucidate
progress
field
intestinal
research
to
provide
reference
for
future
EV
studies,
also
discussed
clinical
pharmacological
potential
EVs,
well
necessary
efforts
required
understand
mechanisms
interaction
pathogenesis.
Nutrients,
Год журнала:
2023,
Номер
15(22), С. 4722 - 4722
Опубликована: Ноя. 8, 2023
Inflammatory
bowel
disease
(IBD)
is
a
chronic
and
recurrent
disease.
It
has
been
observed
that
the
incidence
prevalence
of
IBD
are
increasing,
which
consequently
raises
risk
developing
colon
cancer.
Recently,
regulation
intestinal
barrier
by
probiotics
become
an
effective
treatment
for
colitis.
Akkermansia
muciniphila-derived
extracellular
vesicles
(Akk
EVs)
nano-vesicles
contain
multiple
bioactive
macromolecules
with
potential
to
modulate
barrier.
In
this
study,
we
used
ultrafiltration
in
conjunction
high-speed
centrifugation
extract
Akk
EVs.
A
lipopolysaccharide
(LPS)-induced
RAW264.7
cell
model
was
established
assess
anti-inflammatory
effects
found
EVs
were
able
be
absorbed
cells
significantly
reduce
expression
nitric
oxide
(NO),
TNF-α,
IL-1β
(p
<
0.05).
We
explored
preventative
on
colitis
regulating
using
mouse
caused
dextran
sulfate
sodium
(DSS).
The
findings
demonstrated
effectively
prevented
symptoms
reduced
colonic
tissue
injury.
Additionally,
enhanced
effectiveness
elevating
MUC2
(0.53
±
0.07),
improving
mucus
integrity,
reducing
permeability
Moreover,
increased
proportion
beneficial
bacteria
Firmicutes
(33.01
0.09%)
downregulated
harmful
Proteobacteria
(0.32
0.27%).
These
suggest
possess
ability
regulate
immune
responses,
protect
barriers,
gut
microbiota.
research
presents
intervention
approach
prevent