Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 23, 2024
Tuberculosis
(TB),
caused
by
the
bacterial
pathogen
Mycobacterium
tuberculosis
(MTB)
,
remains
one
of
most
prevalent
and
deadly
infectious
diseases
worldwide.
Currently,
there
are
complex
interactions
between
host
cells
pathogens
in
TB.
The
onset,
progression,
regression
TB
correlated
not
only
with
virulence
MTB
but
also
immunity
patients.
Exosomes
cell-secreted
membrane-bound
nanovesicles
lipid
bilayers
that
contain
a
variety
biomolecules,
such
as
metabolites,
lipids,
proteins,
nucleic
acids.
Exosome-mediated
cell−cell
communication
microenvironment
represent
crucial
mechanisms
through
which
exosomes
exert
their
functional
effects.
harbor
wide
range
regulatory
roles
physiological
pathological
conditions,
including
infection.
can
regulate
immune
response,
metabolism,
cellular
death
to
remodel
progression
During
infection,
display
distinctive
profiles
quantities
may
act
diagnostic
biomarkers,
suggesting
provide
revealing
glimpse
into
evolving
landscape
infections.
Furthermore,
derived
from
mesenchymal
stem
be
harnessed
vaccine
platforms
drug
delivery
vehicles
for
precise
targeting
treatment
In
this
review,
we
highlight
functions
influence
Additionally,
unravel
critical
significance
exosomal
constituents
diagnosis
therapeutic
applications
TB,
aiming
offer
novel
perspectives
strategies
combating
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
264, С. 130728 - 130728
Опубликована: Март 11, 2024
Exosomes
(EXOs),
minute
membranous
structures
originating
from
diverse
biological
sources,
have
recently
seized
the
attention
of
researchers
due
to
their
theranostic
potential
for
neurological
diseases.
Released
actively
by
various
cells,
including
stem
adipose
tissue,
and
immune
EXOs
wield
substantial
regulatory
influence
over
intricate
landscape
complications,
exhibiting
both
positive
negative
modulatory
effects.
In
AD,
play
a
pivotal
role
in
disseminating
breaking
down
amyloid-β
protein.
Moreover,
derived
mesenchymal
cells
showcase
remarkable
capacity
mitigate
pro-inflammatory
phenotypes
regulating
miRNAs
neurodegenerative
These
vesicles
possess
unique
ability
traverse
blood-brain
barrier,
governing
aggregation
mutant
huntingtin
Understanding
exosomal
functions
within
CNS
holds
significant
promise
enhancing
treatment
efficacy
This
review
intricately
examines
mechanisms
involving
disease
development,
highlighting
therapeutic
prospects
exploring
utility
exosome-based
nanomedicine
complications.
Additionally,
delves
into
challenges
associated
with
drug
delivery
brain,
emphasizing
complexities
inherent
this
critical
aspect
neurotherapeutics.
Bioactive Materials,
Год журнала:
2024,
Номер
36, С. 126 - 156
Опубликована: Март 2, 2024
Small
extracellular
vesicles
(sEVs)
are
known
to
be
secreted
by
a
vast
majority
of
cells.
These
sEVs,
specifically
exosomes,
induce
specific
cell-to-cell
interactions
and
can
activate
signaling
pathways
in
recipient
cells
through
fusion
or
interaction.
nanovesicles
possess
several
desirable
properties,
making
them
ideal
for
regenerative
medicine
nanomedicine
applications.
properties
include
exceptional
stability,
biocompatibility,
wide
biodistribution,
minimal
immunogenicity.
However,
the
practical
utilization
particularly
clinical
settings
at
large
scale,
is
hindered
expensive
procedures
required
their
isolation,
limited
circulation
lifetime,
suboptimal
targeting
capacity.
Despite
these
challenges,
sEVs
have
demonstrated
remarkable
ability
accommodate
various
cargoes
found
extensive
applications
biomedical
sciences.
To
overcome
limitations
broaden
potential
applications,
researchers
should
strive
deepen
understanding
current
loading,
characterization
techniques.
Additionally,
acquiring
fundamental
knowledge
about
origins
employing
state-of-the-art
methodologies
expand
research
scope.
This
review
provides
comprehensive
overview
exosome-based
strategies
diverse
domains,
encompassing
cancer
therapy,
immunotherapy,
biomarker
Furthermore,
we
emphasize
immense
exosomes
medicine.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1285 - 1302
Опубликована: Янв. 1, 2025
Treatment
for
bone
and
joint
tuberculosis
(BJTB)
is
challenging
due
to
its
refractory
recurrent
nature.
This
study
aimed
develop
a
bioimplantable
scaffold
with
osteoinductive
antituberculosis
characteristics
treat
BJTB.
built
on
oxidized
hyaluronic
acid
carboxymethyl
chitosan
hydrogel
mixed
hydroxyapatite
as
tissue
engineered
material.
In
order
make
the
have
biological
activity
of
promoting
repair,
exosomes
(Exoeng)
were
added
innovatively.
addition,
drug-loaded
liposomes
equipped
an
aldehyde
group
surface
are
cross-linked
amine
skeleton
participate
in
Schiff
base
reaction.
The
designed
has
self-healing
injectability
exhibit
excellent
anti-tuberculosis
repair
activities.
Exoeng
strongly
stimulates
cellular
angiogenesis
osteogenic
differentiation.
coated
can
release
three
kinds
drugs
smoothly
slowly,
achieving
long
term
anti-tuberculosis.
composite
bio-scaffold
shows
good
long-term
abilities,
which
expected
provide
viable
treatment
plan
bone-related
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
Extracellular
vesicles
(EVs)
are
nanosized
particles
that
released
from
cells
and
reflect
the
characteristics
of
mother
cell.
Recently,
EVs
have
been
used
in
several
types
studies
across
many
different
fields.
In
field
EV
research,
multiple
cell
culture
isolation
techniques
highlighted
importance.
Various
strategies,
including
exclusive
component
media,
three-dimensional
(3D)
cultures,
hypoxic
conditions,
proposed
for
to
control
function
EVs.
Ultracentrifugation,
ultrafiltration,
precipitation,
tangential
flow
filtration
(TFF)
utilized
isolation.
Although
isolated
their
own
functionalities,
researchers
trying
functionalize
by
applying
various
engineering
approaches.
Gene
editing,
exogenous,
endogenous,
hybridization
methods
four
well-known
functionalization
strategies.
engineered
through
these
processes
has
applied
regenerative
medicine,
kidney
diseases,
osteoarthritis,
rheumatoid
arthritis,
nervous
system-related
others.
this
review,
it
was
focused
on
approaches
applications
medicine.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Дек. 20, 2023
Exosomes
are
extracellular
vesicles
with
the
diameter
of
30
~
150
nm,
and
widely
involved
in
intercellular
communication,
disease
diagnosis
drug
delivery
carriers
for
targeted
therapy.
Therapeutic
application
exosomes
as
is
limited
due
to
lack
sources
methods
obtaining
adequate
exosomes.
Milk
contains
abundant
exosomes,
several
studies
have
shown
that
milk-derived
play
crucial
roles
preventing
treating
intestinal
diseases.
In
this
review,
we
summarized
biogenesis,
secretion
structure,
current
novel
used
extraction
identification
well
discussed
role
diseases,
such
inflammatory
bowel
disease,
necrotizing
enterocolitis,
colorectal
cancer,
ischemia
reperfusion
injury
by
regulating
immune
homeostasis,
restoring
gut
microbiota
composition
improving
structure
integrity,
alleviating
conditions
oxidative
stress,
cell
apoptosis
inflammation,
reducing
mitochondrial
reactive
oxygen
species
(ROS)
lysosome
accumulation
both
humans
animals.
addition,
future
prospects
standardization
milk
exosome
production
platform
obtain
higher
concentration
purity,
complete
derived
from
milk.
Several
vivo
clinical
needed
establish
an
effective
efficient
system,
promote
its
treatment
various
diseases
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114955 - 114955
Опубликована: Июнь 1, 2023
Bioactive
natural
products
(BNPs)
are
the
marrow
of
medicinal
plants,
which
secondary
metabolites
organisms
and
have
been
most
famous
drug
discovery
database.
for
their
enormous
number
great
safety
in
medical
applications.
However,
BNPs
troubled
by
poor
druggability
compared
with
synthesis
drugs
challenged
as
medicine
(only
a
few
applied
clinical
settings).
In
order
to
find
reasonable
solution
improving
BNPs,
this
review
summarizes
bioactive
nature
based
on
pharmacological
research
tries
explain
reasons
BNPs.
And
then
focused
boosting
loaded
delivery
systems,
further
concludes
advantages
systems
improvement
from
perspective
nature,
discusses
why
need
predicts
next
direction.
