26th International Conference on Optical Fiber Sensors, Год журнала: 2023, Номер unknown, С. Th5.1 - Th5.1
Опубликована: Янв. 1, 2023
The paper provides an overall picture of the technological roadmap aimed to develop Lab on fiber (LOF) assisted needles for in-vivo liquid and tissue biopsy support light localized therapies precision medicine.
Язык: Английский
Saudi Pharmaceutical Journal, Год журнала: 2024, Номер 32(5), С. 102064 - 102064
Опубликована: Апрель 7, 2024
Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for treatment of HCC; however, reported response rate to such therapeutic suboptimal (<3%). Piperine (PIP) an alkaloid demonstrated exert direct tumoricidal activity HCC and improve pharmacokinetic profiles anticancer drugs including SORA. In this study, we developed strategy efficacy outcomes using PIP as add-on support first-line SORA biodegradable Poly (D, L-Lactide-co-glycolide, PLGA) nanoparticles (NPs). (both exhibit low aqueous solubility) were co-loaded into PLGA NPs (PNPs) stabilized with various concentrations polyvinyl alcohol (PVA). The PIP-loaded PNPs (SP-PNPs) characterized Fourier Transform Infrared (FTIR) Spectroscopy, X-ray Powder Diffraction (XRD), Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), Release these from SP-PNPs was investigated vitro at both physiological acidic pH, kinetic models employed assess mechanism drug release. against cells (HepG2) also evaluated. FTIR XRD analyses revealed that encapsulated amorphous state, no observed chemical interactions among or excipients. Assessment release pH 5 7.4 showed loaded 0.5 % PVA released sustained manner, unlike pure drugs, which exhibited relatively fast spherical, had average size 224 nm, encapsulation efficiency (SORA ∼ 82 %, 79 %), well superior cytotoxicity compared monotherapy vitro. These results suggest combining may be effective set comprehensive vivo study evaluate safety novel formulation murine model.
Язык: Английский
Процитировано
10
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 13, 2024
Current research in cancer therapy focuses on personalized therapies, through nanotechnology-based targeted drug delivery systems. Particularly, controlled release with nanoparticles (NPs) can be designed to safely transport various active agents, optimizing specific organs and tumors, minimizing side effects. The use of microfluidics (MFs) this field has stood out against conventional methods by allowing precise control over parameters like size, structure, composition, mechanical/biological properties nanoscale carriers. This review compiles applications the production core-shell NPs (CSNPs) for therapy, discussing versatility inherent microchannel and/or micromixer setups showcasing how these utilized individually or combination, as well technology allows development new advances more efficient fabrication nanoformulations. Recent biological studies have achieved an effective, safe, otherwise unreliable encapsulants such small interfering RNA (siRNA), plasmid DNA (pDNA), cisplatin a result precisely tuned nanocarriers, showing that is paving way innovative strategies nanofabrication, characterized continuous high reproducibility. Finally, analyzes technical, biological, technological limitations currently prevent from becoming standard.
Язык: Английский
Процитировано
10
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
The liver performs crucial roles in energy metabolism, detoxification, and immune regulation. Hepatic diseases, including hepatitis, fibrosis, cancer, have posed a significant threat to global health, emphasizing the critical need for development of novel effective treatment approaches. Nanotechnology, an emerging technology, has been extensively researched medicine. Among many types nanomaterials, polymeric nanoparticles (NPs) are widely used drug delivery systems. Compared traditional therapies, they offer advantages disease by improving outcomes reducing side effects. This review introduced discussed application natural polymers synthetic their management. Furthermore, this paper reviewed -mainly chitosan (CS), hyaluronic acid (HA), polyethylene glycol (PEG) poly (lactic-co-glycolic acid) (PLGA)-in treatment, focusing on use various systems pure bioactive compounds origin, drugs, nucleic acids, peptides, others. Finally, challenges future perspectives NPs were provide guidance further research directions, with aim promoting clinical nanotherapeutics treating hepatic diseases.
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 299, С. 140030 - 140030
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117118 - 117118
Опубликована: Июль 14, 2024
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.
Язык: Английский
Процитировано
7
Nanomedicine, Год журнала: 2023, Номер 18(23), С. 1613 - 1634
Опубликована: Окт. 1, 2023
To develop hyaluronic acid (HA)-coated poly-lactic-co-glycolic (PLGA)-polysarcosine (PSAR) coupled sorafenib tosylate (SF) polymeric nanoparticles for targeted colon cancer therapy.
Язык: Английский
Процитировано
10
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(7), С. 4336 - 4346
Опубликована: Июнь 8, 2024
Prostate cancer (PCa) with a high incidence worldwide is serious threat to men's health. Despite the continuous development of treatment strategies for PCa in recent years, long-term prognosis patients still poor. Hence, discovery and novel, secure, efficient therapeutic approaches hold significant clinical significance. Although sorafenib (SOR) displays potential as option PCa, its efficacy hindered by drug resistance, limited water solubility, rapid metabolism. Therefore, we proposed prepare nanoparticles (named SOR@8P4 NPs) utilizing phenylalanine-based poly(ester amide) polymer (8P4) carrier enhance solubility stability SOR improve targeting bioavailability. NPs had showed acid-responsive release at acidic tumor microenvironment. Additionally, demonstrated more remarkable anticancer, antimetastatic, antiproliferative abilities vitro, compared those free drugs. significantly inhibited growth vivo. In summary, delivery system provides new ideas PCa.
Язык: Английский
Процитировано
3
Journal of Hepatocellular Carcinoma, Год журнала: 2024, Номер Volume 11, С. 1265 - 1278
Опубликована: Июль 1, 2024
Abstract: Ferroptosis is a type of cell death that relies on iron and distinguished by the occurrence lipid peroxidation buildup reactive oxygen species. has been demonstrated to have significant impact advancement resistance treatment hepatocellular carcinoma (HCC), thereby highlighting its potential as viable therapeutic target. was observed in HCC tissues contrast normal liver tissue. The inhibition ferroptosis found increase viability cells decrease their susceptibility various anticancer therapies, including chemotherapy, radiotherapy, immune checkpoint blockade. administration drugs directly modulate regulators or induce excessive production lipid-reactive species enhance responsiveness drug-resistant treatment. However, precise mechanism underlying this phenomenon remains ambiguous. This review presents comprehensive overview crucial role played enhancing efficacy for (HCC). main aim study examine feasibility utilizing approach improve overcome drug resistance. Keywords: ferroptosis, carcinoma, tyrosine kinase inhibitor, immunosuppressive therapy, radiotherapy
Язык: Английский
Процитировано
3
Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2024, Номер unknown, С. 102508 - 102508
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
3
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 26, 2025
Nanomedicine has received much attention for its potential applications in the diagnosis and treatment of liver cancer. However, no bibliometric evaluation been conducted to present an assessment scientific progress field. The aim this study is comprehensively catalog cooperation influence journals, countries, institutions, authors field nanomedicine cancer from perspective bibliometrics, evaluate clustering evolution knowledge structure, uncover hot topics emerging themes. Articles reviews related were retrieved Web Science Core Literature Library using Topic Search. #1 T= ("Hepatic Neoplasm*" OR "Liver Neoplasm" Cancer*" "Hepatocellular "Hepatic Cancer*"), #2 "nano*", search strategy set as AND limited Citation Index Expanded database source, with limitation publication types language/time. Bibliometric studies CiteSpace VOSviewer. 2,648 articles included 2000 2024. number regarding showed increasing trend. Analysis most productive journals shows that are specialized nanoscience nanotechnology, pharmacology pharmacy, chemistry multidisciplinary. These publications mainly come 8,782 institutions 297 countries led by China United States America. Shao D published papers among publications, while Jemal A had co-citations. macroscopical sketch micro-representation whole realized through co-citation analysis. Hepatocellular carcinoma, targeted delivery, sorafenib nanoparticles, others current developing areas study. keywords "nanocrystals," "biodistribution," "particles" also may be focus new trends future research. In study, bibliometrics visual methods used review research comprehensively. article will help scholars gain a better understanding dynamic point directions
Язык: Английский
Процитировано
0