Drug development & registration,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Introduction.
Cellular
systems
for
targeted
delivery
of
drug
and
biological
molecules
(drug
systems,
DDSs)
are
currently
considered
as
a
promising
solution
to
the
problems
nano-
micro-sized
carriers.
Text.
The
review
briefly
examines
fundamental
applied
issues
in
development
cellular
DDSs,
morphofunctional
diversity
which
theoretically
makes
it
possible
solve
pharmacotherapy
various
diseases.
Sources
presented
summarizing
clinical
protocols
use
are,
however,
limited
antitumor
anti-inflammatory
therapy.
advantages,
well
particular
general
disadvantages
using
certain
cells
(blood
cells,
immunocytes,
stem
cells)
platforms
translation
into
practice
vehicles
drugs
(antibiotics,
cytostatics,
monoclonal
antibodies,
enzymes,
etc.)
loaded
DDSs.
Conclusion.
Despite
obvious
impressive
successes
research
this
area,
difficult
path
lies
ahead
optimizing
processes
controlled
release
Pharmaceutics,
Год журнала:
2025,
Номер
17(6), С. 705 - 705
Опубликована: Май 27, 2025
Background/Objectives:
In
vitro,
vancomycin
(VAN)
and
tetrahydrolipstatin
(THL)
together
have
been
shown
to
synergistically
inhibit
Mycobacterium
tuberculosis
(Mtb),
the
world’s
most
infectious
killer.
The
poor
oral
bioavailability
of
VAN
THL
predominant
tropism
Mtb
infection
lungs
alveolar
macrophages
make
pulmonary
administration
highly
attractive.
This
study
aimed
develop
assess
efficacy
dry
powders
for
inhalation
microparticles
embedded
with
THL.
Methods:
produced
by
spray-drying,
or
without
hydrogenated
castor
oil
(HCO),
were
characterized
their
physicochemical
properties
among
others
HPLC-DAD.
fast-screening
impactor
was
used
determine
powder
aerodynamic
properties,
releases
established
from
paddle
over
disk
method.
Biological
activities
assessed
in
a
new
M.
bovis-infected
macrophage
model
Mtb-infected
mice.
Results
Discussion:
addition
25%
HCO
enables
co-deposition
(fine
particle
dose)
at
desired
weight
ratio
co-releasing
aqueous
media.
Microparticles
0%
50%
drastically
reduced
cytoplasmic
bovis
survival
(99.9%
62.5%,
respectively),
higher
low
concentration.
Consequently,
VAN/THL
evaluated
Although
no
decrease
lung
burden
observed
after
two
weeks
administration,
endotracheal
500
mg/kg
50
administrated
three
times
during
five
days
concomitantly
daily
rifampicin
(10
mg/kg)
demonstrated
2-fold
bacterial
reduction
compared
group
treated
RIF
alone.
Conclusions:
crucial
obtaining
fine
dose
synergistic
(VAN/THL
10:1)
releasing
both
drugs
With
first-line
rifampicin,
VAN/THL/25%
able
exert
potential
anti-tubercular
effect
vivo
mice
days.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 13615 - 13651
Опубликована: Дек. 1, 2024
Macrophage
is
an
important
component
in
the
tumor
immune
microenvironment,
which
exerts
significant
influence
on
development
and
metastasis.
Due
to
their
dual
nature
of
promoting
suppressing
inflammation,
macrophages
can
serve
as
both
targets
for
immunotherapy
tools
treating
malignancies.
However,
abundant
infiltration
tumor-associated
dominated
by
immunosuppressive
phenotype
maintains
a
pro-tumor
engineering
using
nanotechnology
manipulate
microenvironment
represent
feasible
approach
cancer
immunotherapy.
Additionally,
considering
phagocytic
specifically
tumor-targeting
capabilities
M1
macrophages,
manipulated
through
cellular
nanotechnology,
well
macrophage-derived
exosomes
macrophage
membranes,
also
become
effective
treatment.
In
conclusion,
nanotherapeutics
targeting
remains
immense
potential
macrophage-mediated
treatment
methods
will
further
enhance
our
understanding,
diagnosis,
various
malignants.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13167 - 13167
Опубликована: Дек. 7, 2024
Hepatocellular
carcinoma
(HCC)
represents
a
significant
clinical
burden
globally
and
is
predicted
to
continue
increase
in
incidence
for
the
foreseeable
future.
The
treatment
of
HCC
complicated
by
fact
that,
majority
cases,
it
develops
on
background
advanced
chronic
inflammatory
liver
disease.
Chronic
inflammation
can
foster
an
immunosuppressive
microenvironment
that
promotes
tumour
progression
metastasis.
In
this
setting,
macrophages
make
up
major
immune
component
microenvironment,
review,
we
focus
their
contribution
development
progression.
Tumour-associated
(TAMs)
are
largely
derived
from
infiltrating
monocytes
potent
anti-inflammatory
phenotype
be
induced
factors
found
within
such
as
growth
factors,
cytokines,
hypoxia,
extracellular
matrix
(ECM)
proteins.
general,
experimental
evidence
suggest
TAMs
exhibit
variety
functions
aid
progression,
including
promotion
angiogenesis,
resistance
drug
therapy,
releasing
support
cell
proliferation
Despite
tumour-promoting
profile,
there
underlying
plasticity
these
cells
targeted
help
reprogramme
drive
tumour-specific
responses.
We
discuss
potential
targeting
therapeutically
either
altering
or
therapy
approaches
taking
advantage
infiltrative
properties
circulation
into
tissue.
Journal of advanced health research & clinical medicine.,
Год журнала:
2024,
Номер
1(1), С. 3 - 12
Опубликована: Янв. 1, 2024
The
prevalence
of
atherosclerotic
cardiovascular
disease
(CVD)
is
alarmingly
increasing
across
the
world.
Despite
a
more
detailed
understanding
cardiac
macrophage
heterogeneity
lacking,
their
crucial
role
in
development
and
rupture
plaque
described
as
well.
Furthermore,
functional
plasticity
has
been
involved
myocardial
remodeling
scar
formation
postinfarct
tissue.
Among
two
types
macrophages
that
exists,
classical
M1
incidence
coronary
artery
lesions,
while
alternate
M2
are
postinfarction
tissue
repair.
Different
cytokines
chemokines
released
from
pro-inflammatory
type
augment
rupture.
More
accumulation
was
evident
rupture-prone
areas
plaque.
cells
were
found
stable
regions
plaque,
away
lipid
core
thus
resist
foam
cell
formation.
Persistent
inflammation
hallmark
chronic
heart
failure.
subtypes
macrophages,
such
M2a,
M2b,
M2c,
M2d,
described.
M2b
inhibit
leukocyte
infiltration
may
have
anti-atherosclerotic
effects/protection
disease,
among
others.
Various
detection
methods
for
polarization
described,
which
include
identification
surface
markers/secretary
proteins
using
quantitative
polymerase
chain
reaction
(PCR),
enzyme-linked
immunosorbent
assay
(ELISA),
Western
blot,
flow
cytometric
analysis,
immunohistochemistry.
Considering
maintenance
homeostasis,
balanced
offers
new
ideal
target
therapeutic
manipulation.
This
review
article
discusses
an
update
on
CVD.
Drug development & registration,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Introduction.
Cellular
systems
for
targeted
delivery
of
drug
and
biological
molecules
(drug
systems,
DDSs)
are
currently
considered
as
a
promising
solution
to
the
problems
nano-
micro-sized
carriers.
Text.
The
review
briefly
examines
fundamental
applied
issues
in
development
cellular
DDSs,
morphofunctional
diversity
which
theoretically
makes
it
possible
solve
pharmacotherapy
various
diseases.
Sources
presented
summarizing
clinical
protocols
use
are,
however,
limited
antitumor
anti-inflammatory
therapy.
advantages,
well
particular
general
disadvantages
using
certain
cells
(blood
cells,
immunocytes,
stem
cells)
platforms
translation
into
practice
vehicles
drugs
(antibiotics,
cytostatics,
monoclonal
antibodies,
enzymes,
etc.)
loaded
DDSs.
Conclusion.
Despite
obvious
impressive
successes
research
this
area,
difficult
path
lies
ahead
optimizing
processes
controlled
release
