Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 275 - 300
Опубликована: Окт. 11, 2024
An
extensive
variety
of
etiologies,
including
trauma
and
chronic
health
issues,
can
result
in
peripheral
nerve
injuries.
These
injuries
provide
significant
hurdles
regarding
clinical
care
the
eventual
restoration
usual
ability.
In
response
to
these
obstacles,
nanoparticles
have
become
a
viable
therapeutic
approach
that
has
potential
accelerate
regeneration.
This
chapter
includes
thorough
examination
categories
synthetic
processes
related
nanoparticles.
Here,
will
illustrate
critical
role
play
advancing
field
regeneration
through
this
comprehensive
investigation.
World Journal of Stem Cells,
Год журнала:
2024,
Номер
16(5), С. 467 - 478
Опубликована: Май 23, 2024
Unlike
central
nervous
system
injuries,
peripheral
nerve
injuries
(PNIs)
are
often
characterized
by
more
or
less
successful
axonal
regeneration.
However,
structural
and
functional
recovery
is
a
senile
process
involving
multifaceted
cellular
molecular
processes.
The
contemporary
treatment
options
limited,
with
surgical
intervention
as
the
gold-standard
method;
however,
each
option
has
its
associated
limitations,
especially
when
injury
severe
large
gap.
Recent
advancements
in
cell-based
therapy
cell-free
approaches
using
stem
cell-derived
soluble
insoluble
components
of
cell
secretome
fast-emerging
therapeutic
to
treating
acute
chronic
PNI.
recent
pilot
study
leap
forward
field,
which
expected
pave
way
for
enormous,
systematic,
well-designed
clinical
trials
assess
efficacy
mesenchymal
exosomes
bio-drug
either
alone
part
combinatorial
approach,
an
attempt
synergize
best
novel
address
complexity
neural
repair
Nanotechnology Reviews,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Inducing
an
anti-inflammatory
response
before
neurogenesis
is
crucial
in
effectively
addressing
peripheral
nerve
damage.
Herein,
we
developed
shell-core-structured
nanofilms
(Cur/PLCL@BDNF/CNT)
using
poly-(
l
-Lactide)-Caprolactone
(PLCL)
and
curcumin
(Cur,
agent)
as
the
shell
layer,
carbon
nanotubes
(CNT)
brain-derived
neurotrophic
factor
(BDNF,
a
neurogenic
factor)
core
via
coaxial
electrospinning
technology.
The
resulting
Cur/PLCL@BDNF/CNT
film
exhibited
characteristic
fibrous
structure
with
remarkable
shell-core
architecture,
demonstrating
unweakened
mechanical
properties.
Notably,
it
displayed
sustained
release
kinetics
distinct
stages:
prioritized
Cur
within
initial
12
days
delayed
BDNF
between
10
to
30
days.
Additionally,
demonstrated
high
biocompatibility
Schwann
cells.
Subsequent
vitro
analysis
revealed
potent
capabilities
of
released
from
while
layer
induced
differentiation
was
rolled
into
conduit
then
utilized
for
regeneration
mm
rat
sciatic
defect
model.
staged
facilitated
by
established
microenvironment
initiating
regeneration,
better
restoration.
This
study
emphasizes
significance
temporally
regulating
anti-inflammation
neurogenesis.
Balneo and PRM Research Journal,
Год журнала:
2024,
Номер
15(Vol.15, no. 2), С. 680 - 680
Опубликована: Июнь 21, 2024
Background:
Peripheral
nerve
injuries
(PNI)
can
generate
important
medium-
and
long-term
disability,
as
patients
mostly
complain
about
associated
pain,
sensibility
and,
or
motor
deficit,
even
psychological
manifestations.
Chitosan
different
nanoparticles
types
were
previously
used
in
several
studies
treatment
of
peripheral
injuries.
The
present
study
aimed
to
assess
the
hepatic
responses
at
oral
administration
simple
chitosan
solution
magnetic
iron
oxide
functionalized
with
(CMNPs)
an
experimentally
induced
injury.
(2)
Methods:
CMNPs
administrated,
for
21
days,
animals
treated
groups
compared
a
control
group
(peripheric
injury
without
any
treatment).
toxicity
administered
solutions
was
analyzed
histologically,
through
transmission
electron
microscopy
(TEM)
oxidative
stress
parameters,
comparison
group.
(3)
Results:
Liver
tissue
histological
evaluation
showed
non-significant
degeneration
hepatocytes
group,
slight
periportal
inflammation.
TEM
investigation
revealed
nuclear
mitochondrial
polymorphism
lipid
accumulation
irregular
nucleus
profiles
increased
glycogen
storage
cytosol.
Oxidative
analysis
antioxidant
effect
both
treatments.
(4)
Conclusions:
Compared
treatments
produced
significant
increases
protection,
probably
by
properties.
Histological
modifications
liver
minimal
groups.
unspecific
alterations
structure.
Keywords:
chitosan;
nanoparticles;
injury;
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5951 - 5952
Опубликована: Июнь 1, 2024
Infections
by
bacteria
cause
significant
health
issues,
affecting
approximately
258
million
people
globally
and
leading
to
280,000
deaths
every
year.
1
In
particular,
Staphylococcus
aureus
Pseudomonas
aeruginosa
are
the
dangerous,
often
causing
pneumonia,
bone
heart
infections.
2
At
present,
polymerase
chain
reaction
(PCR)
has
been
widely
used
as
a
reliable
excellent
diagnostic
technique
at
genetic
level
confirm
identify
infected
pathogen.
3However,
PCR
is
expensive,
time-consuming
some
specific
primers
different
microorganisms,
physicians
need
list
potential
microorganisms
before
performing
selective
PCR.Therefore,
providing
accurate
rapid
identification
for
become
mandatory
wide
applications.In
recent
research,
Cheng
his
group
developed
sandwich
SARS
immunoassay
using
magnetic
nanoparticles
(MGNP),
wheat
germ
agglutinin
(WGA),
gold
nanostars
(AuNS)
identifying
bacterial
pathogens.
4As
indicated
in
this
nanomaterials
commonly
enhance
Raman
signal
diagnosing
pathogenic
bacteria.
5heng
et
al
antibodies
S.
P.
aeruginosa,
conjugated
with
MGNP,
capture
probe.AuNS
was
modified
WGA
5.5'-dithiobis-(2-nitrobenzoic
acid)
utilized
signalling
complex
(SERS
tag).Target
were
captured
antibody-conjugated
MGNPs
combined
SERS
tags
form
complex.Since
performance
of
sensor
highly
relies
on
influences
tag,
displayed
highest
binding
affinity
aeruginosa.This
newly
introduced
AuNS,
proved
have
strong
capabilities,
evidenced
tag
attachments
surface
intact
bacteria,
increasing
signal.Additionally,
intensity
enhanced
proportionally
concentrations,
limits
detection
improved
5
7
CFU/mL,
respectively.With
spiked
samples
urine,
researchers
higher
concentrations
(50,
500,
5000
CFU/mL),
clear
observed.However,
it
would
be
better
use
lower
match
levels
urine
samples.Overall,
current
research
shows
pathogen
nanomaterial
platform
that
can
mimicked
other
novel
nanomaterials.The
novelty
work
promising,
biosensor
model
could
well
biomarkers
diagnose
diseases
earlier
stages.Furthermore,
similar
sensing
might
created
open
up
new
possibilities
high-performance
point-of-care
testing.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 275 - 300
Опубликована: Окт. 11, 2024
An
extensive
variety
of
etiologies,
including
trauma
and
chronic
health
issues,
can
result
in
peripheral
nerve
injuries.
These
injuries
provide
significant
hurdles
regarding
clinical
care
the
eventual
restoration
usual
ability.
In
response
to
these
obstacles,
nanoparticles
have
become
a
viable
therapeutic
approach
that
has
potential
accelerate
regeneration.
This
chapter
includes
thorough
examination
categories
synthetic
processes
related
nanoparticles.
Here,
will
illustrate
critical
role
play
advancing
field
regeneration
through
this
comprehensive
investigation.
