Methods in pharmacology and toxicology, Год журнала: 2025, Номер unknown, С. 437 - 459
Опубликована: Янв. 1, 2025
Язык: Английский
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5523 - 5544
Опубликована: Июнь 1, 2024
Metal-organic frameworks (MOFs) are porous materials resulting from the coordination of metal clusters or ions with organic ligands, merging macromolecular and chemistry features. Among these, zeolitic imidazolate framework-8 (ZIF-8) stands out as a widely utilized MOF known for its robust stability in aqueous environments owing to interaction between constituent zinc (Zn
Язык: Английский
Процитировано
25
ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(4), С. 967 - 990
Опубликована: Март 19, 2024
Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized effective disease management. Identification key driver mutations molecular profiling have deepened our comprehension genetic alterations in cancer, facilitating targeted therapy immunotherapy selection. Biomarkers such as microsatellite instability (MSI) DNA mismatch repair deficiency (dMMR) guide decisions, opening avenues for immunotherapy. Emerging liquid biopsies, artificial intelligence, machine learning promise to revolutionize early detection, monitoring, selection precision medicine. Despite these advancements, ethical regulatory challenges, including equitable access data privacy, emphasize importance responsible implementation. The dynamic nature with its tumor heterogeneity clonal evolution, underscores necessity adaptive strategies. future lies potential enhance patient care, clinical outcomes, understanding this intricate disease, marked by ongoing evolution field. current reviews focus on providing in-depth knowledge various diverse approaches utilized against at both biochemical levels.
Язык: Английский
Процитировано
19
Chemical Reviews, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Язык: Английский
Процитировано
5
Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 126999 - 126999
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114548 - 114548
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
3
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110854 - 110854
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125354 - 125354
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
AAPS PharmSciTech, Год журнала: 2025, Номер 26(3)
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(8), С. 1848 - 1848
Опубликована: Апрель 18, 2024
In recent years, the frequency of strokes has been on rise year by and become second leading cause death around world, which is characterized a high mortality rate, recurrence disability rate. Ischemic account for large percentage strokes. A reperfusion injury in ischemic complex cascade oxidative stress, neuroinflammation, immune infiltration, mitochondrial damage. Conventional treatments are ineffective, presence blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers turning their attention nano-drug systems. Functionalized systems have widely studied applied study cerebral diseases due favorable biocompatibility, efficiency, strong specificity, specific targeting ability. this paper, we briefly describe pathological process injuries focus therapeutic research progress strokes, aiming provide certain references understand (NDDSs).
Язык: Английский
Процитировано
3
Technology in Cancer Research & Treatment, Год журнала: 2024, Номер 23
Опубликована: Янв. 1, 2024
Single biofilm biomimetic nanodrug delivery systems based on single cell membranes, such as erythrocytes and cancer cells, have immune evasion ability, good biocompatibility, prolonged blood circulation, high tumor targeting. Because of the different characteristics functions each membrane, more researchers are using various hybrid membranes according to their specific needs. This review focuses several types nanodrug-delivery composite biofilms looks forward challenges possible development directions provide reference ideas for future research.
Язык: Английский
Процитировано
3