International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 6829 - 6843
Опубликована: Июль 1, 2024
Background:
With
the
rapid
development
of
nanotechnology,
constructing
a
multifunctional
nanoplatform
that
can
deliver
various
therapeutic
agents
in
different
departments
and
respond
to
endogenous/exogenous
stimuli
for
multimodal
synergistic
cancer
therapy
remains
major
challenge
address
inherent
limitations
chemotherapy.
Methods:
Herein,
we
synthesized
hollow
mesoporous
Prussian
Blue@zinc
phosphate
nanoparticles
load
glucose
oxidase
(GOx)
DOX
(designed
as
HMPB-GOx@ZnP-DOX
NPs)
non-identical
pore
structures
their
HMPB
core
ZnP
shell,
respectively,
photothermally
augmented
chemo-starvation
therapy.
Results:
The
shell
coated
on
core,
addition
providing
space
chemotherapy,
could
also
serve
gatekeeper
protect
GOx
from
premature
leakage
inactivation
before
reaching
tumor
site
because
its
degradation
characteristics
under
mild
acidic
conditions.
Moreover,
loaded
initiate
starvation
by
catalyzing
oxidation
while
causing
an
upgradation
acidity
H
2
O
levels,
which
be
used
forceful
endogenous
trigger
smart
delivery
systems
applications.
decrease
pH
improve
pH-sensitivity
drug
release,
supplied
decomposing
through
catalase-like
activity
HMPBs,
is
beneficial
relieving
adverse
conditions
anti-tumor
activity.
In
addition,
inner
acts
photothermal
agent
generated
hyperthermia
upon
laser
irradiation
external
stimulus
further
promote
release
enzymatic
activities
GOx,
thereby
enabling
synergetic
enhanced
effect.
Importantly,
these
results
indicate
NPs
effectively
inhibit
growth
80.31%
exhibit
no
obvious
systemic
toxicity
mice.
Conclusion:
employed
potential
theranostic
incorporate
multiple
modes
efficiently
tumors.
Keywords:
Blue,
oxidase,
co-delivery
system,
therapy,
chemotherapy
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5523 - 5544
Опубликована: Июнь 1, 2024
Metal-organic
frameworks
(MOFs)
are
porous
materials
resulting
from
the
coordination
of
metal
clusters
or
ions
with
organic
ligands,
merging
macromolecular
and
chemistry
features.
Among
these,
zeolitic
imidazolate
framework-8
(ZIF-8)
stands
out
as
a
widely
utilized
MOF
known
for
its
robust
stability
in
aqueous
environments
owing
to
interaction
between
constituent
zinc
(Zn
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(4), С. 967 - 990
Опубликована: Март 19, 2024
Precision
medicine
is
transforming
colorectal
cancer
treatment
through
the
integration
of
advanced
technologies
and
biomarkers,
enhancing
personalized
effective
disease
management.
Identification
key
driver
mutations
molecular
profiling
have
deepened
our
comprehension
genetic
alterations
in
cancer,
facilitating
targeted
therapy
immunotherapy
selection.
Biomarkers
such
as
microsatellite
instability
(MSI)
DNA
mismatch
repair
deficiency
(dMMR)
guide
decisions,
opening
avenues
for
immunotherapy.
Emerging
liquid
biopsies,
artificial
intelligence,
machine
learning
promise
to
revolutionize
early
detection,
monitoring,
selection
precision
medicine.
Despite
these
advancements,
ethical
regulatory
challenges,
including
equitable
access
data
privacy,
emphasize
importance
responsible
implementation.
The
dynamic
nature
with
its
tumor
heterogeneity
clonal
evolution,
underscores
necessity
adaptive
strategies.
future
lies
potential
enhance
patient
care,
clinical
outcomes,
understanding
this
intricate
disease,
marked
by
ongoing
evolution
field.
current
reviews
focus
on
providing
in-depth
knowledge
various
diverse
approaches
utilized
against
at
both
biochemical
levels.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
International Journal of Applied Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 12 - 22
Опубликована: Янв. 7, 2025
Using
stimuli-responsive
Bio
Interactions
with
controlled
nano-assembly
is
proving
a
potent
method
for
generating
theranostic
nanosystems
that
satisfy
the
needs
of
modern
medicine
example,
targeted
delivery
which
very
helpful
cancer
treatment
minimum
side
effects.
However,
because
limitations
in
our
knowledge,
this
promising
topic
still
proof-of-concept
stage.
This
study
provides
an
overview
most
recent
theoretical
and
experimental
advancements
biological
fate,
functional
activity
nano-assemblies,
nano-bio
interactions
exogenous
stimulus-triggered
systems
(Light-responsive
systems,
Ultrasound-responsive
Magnetic
field-responsive
Thermal-responsive
systems)endogenous
(Ph-Responsive
Systems,
Redox-responsive
Enzyme-responsive
systems)
multi
stimuli
system.
Related
consequences
reactions.
Firstly,
we
intend
to
thoroughly
explain
these
relationships
review.
The
relationship
between
interaction
studies
nano-based
stimuli;
important
physicochemical
characteristics
vivo
stimuli,
such
as
responsive
assembly
disassembly;
applications;
pharmacokinetic
(pk)
parameters
based
on
interaction.
