The role of graphene quantum dots in cutting‐edge medical therapies
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(9)
Опубликована: Сен. 1, 2024
Abstract
Graphene
quantum
dots
(GQDs),
owing
to
their
unique
optical,
electrical,
and
chemical
properties,
have
emerged
as
promising
nanomaterials
for
various
biomedical
applications.
This
review
provides
a
comprehensive
overview
of
the
latest
advancements
in
utilization
GQDs
tissue
engineering,
wound
healing,
drug
delivery
systems,
other
therapies.
The
inherent
properties
GQDs,
including
high
biocompatibility,
tunable
photoluminescence,
significant
surface
area,
make
them
ideal
candidates
enhancing
medical
treatments
diagnostics.
In
improve
mechanical
biological
performance
scaffolds,
promoting
cell
proliferation
differentiation.
For
enhance
antimicrobial
activity
facilitate
faster
regeneration.
Their
potential
DDS
is
highlighted
by
ability
deliver
therapeutic
agents
efficiently,
ensuring
targeted
controlled
release.
Additionally,
play
crucial
role
therapies,
particularly
cancer
treatment,
efficacy
reducing
side
effects.
While
offer
diagnostics,
challenges
such
understanding
long‐term
cytotoxicity
at
higher
concentrations,
need
standardized
synthesis
methods
remain
critical
areas
further
research.
also
discusses
future
directions
opportunities
emphasizing
transformative
advancing
modern
healthcare
solutions.
insights
presented
here
contribute
expanding
field
GQD
research,
highlighting
significantly
patient
outcomes
drive
innovations.
Язык: Английский
Zwitterionic Polymers for Biomedical Applications: Antimicrobial and Antifouling Strategies toward Implantable Medical Devices and Drug Delivery
Sara Moayedi,
Weibo Xia,
Liam Lundergan
и другие.
Langmuir,
Год журнала:
2024,
Номер
40(44), С. 23125 - 23145
Опубликована: Окт. 25, 2024
Poly(ethylene
glycol)
(PEG)
is
extensively
utilized
in
biomedical
applications
due
to
its
biocompatibility;
however,
thermal
instability
and
susceptibility
oxidative
degradation
significantly
constrain
long-term
effectiveness.
Zwitterionic
polymers,
characterized
by
their
distinctive
structure,
enhanced
stability,
superior
biocompatibility,
offer
a
more
advantageous
alternative.
These
polymers
exhibit
super
hydrophilicity,
resist
nonspecific
protein
adsorption,
maintain
stability
biological
environments
charge-neutral
ionic
nature.
enhance
anticancer
drug
delivery
precisely
targeting
tumor
cells
facilitating
an
efficient
release.
Their
inherent
antifouling
properties
prolonged
circulation
within
the
bloodstream
render
them
highly
suitable
for
redox-sensitive
carriers,
thereby
augmenting
antitumor
efficacy.
Moreover,
zwitterionic
markedly
mitigate
biofouling
implants,
biosensors,
wound
dressings,
improving
both
functionality
therapeutic
outcomes.
advantages
arise
from
formation
of
robust
hydration
layers,
which
hemocompatibility
inhibit
adhesion
proteins,
platelets,
bacteria.
including
sulfobetaine
(SB),
phosphorylcholine
(PC),
carboxybetaine
(CB),
are
increasingly
employed
blood-contacting
devices
as
effective
coating
materials
implantable
devices.
This
mini-review
paper
aims
explore
recent
diverse
highlight
compared
with
unmodified
polymers.
We
will
cover
use
systems,
nanocarriers,
antibiofouling
antibacterial
activities
devices,
tissue
engineering,
diagnostic
demonstrating
how
unique
can
translate
into
different
applications.
Through
this
exploration,
Perspective
display
potential
innovative
polymer
field
engineering
beyond.
Язык: Английский
Graphene Quantum Dots as Antifibrotic Therapy for Kidney Disease
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Graphene
quantum
dots
(GQDs)
have
received
much
attention
for
their
biomedical
applications,
such
as
bioimaging
and
drug
delivery.
Additionally,
they
antioxidant
anti-inflammatory
properties.
We
used
GQDs
to
treat
renal
fibrosis
confirmed
ability
protect
cells
from
excessive
oxidative
stress
in
vitro
vivo.
Tubulointerstitial
was
induced
by
unilateral
ureteral
obstruction
(UUO)
7-
8-week-old
male
C57BL/6
mice.
were
administered
intravenous
injection
mimic
clinical
treatment.
The
levels
of
stress,
ROS
production,
apoptosis
proinflammatory
cytokines
the
activity
TGFβ1/Smad
pathway
evaluated
after
treatment
with
GQDs.
In
vitro,
rhTGF-β1
induce
primary
kidney
tubule
epithelial
cells.
alleviated
morphological
changes
UUO
induction.
At
mRNA
protein
levels,
significantly
reduced
expression
fibrotic
markers
cytokines,
decreased
production
TGF-β1
expression,
affected
Smad-dependent
signaling
pathways.
inhibited
rhTGF-β1-induced
epithelial-to-mesenchymal
transition
accumulation.
This
study
revealed
role
fibrosis:
effectively
attenuated
major
fibrogenesis
events
inhibiting
accumulation
vicious
cycle
TGF-β1/Smad
pathways,
well
alleviating
cell
inflammation.
Thus,
may
be
a
therapeutic
option
chronic
disease
progression.
Язык: Английский
Nanozymes for Treating Ocular Diseases
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 13, 2024
Nanozymes,
characterized
by
their
nanoscale
size
and
enzyme-like
catalytic
activities,
exhibit
diverse
therapeutic
potentials,
including
anti-oxidative,
anti-inflammatory,
anti-microbial,
anti-angiogenic
effects.
These
properties
make
them
highly
valuable
in
nanomedicine,
particularly
ocular
therapy,
bypassing
the
need
for
systemic
delivery.
Nanozymes
show
significant
promise
tackling
multi-factored
diseases,
those
influenced
oxidation
inflammation,
like
dry
eye
disease,
age-related
macular
degeneration.
Their
small
size,
coupled
with
ease
of
modification
integration
into
soft
materials,
facilitates
effective
penetration
barriers,
thereby
enabling
targeted
or
prolonged
therapy
within
eye.
This
review
is
dedicated
to
exploring
diseases
that
are
intricately
linked
shedding
light
on
role
nanozymes
managing
these
conditions.
Additionally,
recent
studies
elucidating
advanced
applications
therapeutics,
along
materials
disease
management,
discussed.
Finally,
this
outlines
directions
future
investigations
aimed
at
bridging
gap
between
nanozyme
research
clinical
applications.
Язык: Английский
Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation
Weijie Zhuang,
Kuangwu Pan,
Jie Wu
и другие.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 12, 2025
While
radiotherapy-induced
immunogenic
cell
death
(ICD)
holds
potential
for
enhancing
cancer
immunotherapy,
the
conventional
high-dose
irradiation
often
leads
to
an
immunosuppressive
microenvironment
and
systemic
toxicity.
Therefore,
a
biomimetic
nanoplatform
membrane
coated-nitrogen-doped
graphene
quantum
dots
combined
with
Au
nanoparticles
(C-GAP)
was
developed
in
this
study.
Firstly,
homologous
traceable
targeting
features
of
C-GAP
enables
tumor-selective
accumulation,
providing
reference
selection
timing
radiotherapy.
Secondly,
radiosensitization
by
Low-dose
(LDI)
amplifies
reactive
oxygen
species
(ROS)
generation
trigger
potent
ICD.
Thirdly,
remarkable
immune
remodeling
induced
enhances
CD8+
T
infiltration
effector
function.
Single-cell
RNA
sequencing
revealed
that
C-GAP-LDI
combination
upregulates
TNF
CCL
signaling
pathway
expression
tumor-infiltrating
cells
which
potentiates
tumor
eradication.
Our
findings
present
novel
approach
safe
effective
radioimmunotherapy,
where
sensitized
LDI
achieves
therapeutic
enhancement
through
precise
ICD
induction
activation.
Язык: Английский
Bringing ophthalmology into the scientific world: Novel nanoparticle-based strategies for ocular drug delivery
The Ocular Surface,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations
Biosensors,
Год журнала:
2025,
Номер
15(4), С. 242 - 242
Опубликована: Апрель 11, 2025
Brain
aging
is
a
complex
process
regulated
by
genetic,
environmental,
and
metabolic
factors,
increasing
evidence
suggests
that
environmental
pollutants
can
significantly
accelerate
this
interfering
with
oxidative
stress,
neuroinflammation,
mitochondrial
function-related
signaling
pathways.
Traditional
studies
have
focused
on
the
direct
damage
of
macromolecules
(e.g.,
proteins,
DNA),
while
central
role
senescence-associated
small
molecules
ROS,
PGE2,
lactate)
in
early
regulatory
mechanisms
has
been
long
neglected.
In
study,
we
innovatively
proposed
cascade
framework
"small
molecule
imbalance-signaling
pathway
dysregulation-macromolecule
collapse",
which
reveals
exacerbate
dynamics
brain
through
activation
NLRP3
inflammatory
vesicles
inhibition
HIF-1α.
Meanwhile,
to
address
technical
bottleneck
spatiotemporal
monitoring,
paper
systematically
reviews
cutting-edge
detection
tools
such
as
electrochemical
sensors,
genetically
encoded
fluorescent
probes
antioxidant
quantum
dots
(AQDs).
Among
them,
AQDs
show
unique
advantages
real-time
monitoring
ROS
fluctuations
intervention
virtue
their
ultra-high
specific
surface
area,
controllable
modification,
free
radical
scavenging
ability.
By
integrating
multimodal
techniques
mechanism
studies,
work
provides
new
perspective
for
analyzing
pollutant-induced
lays
methodological
foundation
strategies
based
networks.
Язык: Английский
Inactivation of Antibiotic Resistant Bacteria by Nitrogen-Doped Carbon Quantum Dots through Spontaneous Generation of Intracellular and Extracellular Reactive Oxygen Species
Weibo Xia,
Zixia Wu,
Bingying Hou
и другие.
Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101428 - 101428
Опубликована: Дек. 24, 2024
The
widespread
antibiotic
resistance
has
called
for
alternative
antimicrobial
agents.
Carbon
nanomaterials,
especially
carbon
quantum
dots
(CQDs),
may
be
promising
alternatives
due
to
their
desirable
physicochemical
properties
and
potential
activity,
but
mechanism
remains
investigated.
In
this
study,
nitrogen-doped
(N-CQDs)
were
synthesized
inactivate
antibiotic-resistant
bacteria
treat
bacterial
keratitis.
N-CQDs
via
a
facile
hydrothermal
approach
displayed
uniform
particle
size
of
less
than
10
nm,
featuring
graphitic
structure
functional
groups
including
-OH
-NH2.
demonstrated
activity
against
Staphylococcus
aureus
(S.
aureus)
methicillin-resistant
S.
aureus,
which
was
both
dose-
time-dependent,
reducing
the
survival
rate
below
1
%.
confirmed
by
live/dead
staining.
in
vivo
studies,
more
efficient
treating
drug-resistant
keratitis
corneal
damage
compared
common
levofloxacin.
shown
generate
intracellular
extracellular
ROS,
potentially
caused
oxidative
stress,
membrane
disruption,
cell
death.
This
supported
scanning
transmission
electron
microscopy,
significant
regulation
genes
related
increased
protein
lactate
dehydrogenase
leakage.
study
provided
insight
into
development,
application,
applications.
Язык: Английский