Tissue and Cell, Год журнала: 2024, Номер 91, С. 102624 - 102624
Опубликована: Ноя. 19, 2024
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)
Опубликована: Янв. 13, 2025
The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.
Язык: Английский
Процитировано
19
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 483 - 503
Опубликована: Янв. 1, 2025
Abstract: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part immunotherapy. However, improve efficacy therapy is currently major challenge. Nanomaterials show their unique advantages whole process. At present, nanomaterials have achieved significant accomplishments medical applications, particularly field cancer-targeted therapy, showing enormous potential. It confirmed can not only directly target CAFs, but also interact with microenvironment (TME) immune affect tumorigenesis. As for treatment, could enhance therapeutic effect many ways. Therefore, this review, we first summarized current understanding complex interactions between TME, cells, cells. Next, discussed common modern medicine respective impacts on tumors. Finally, focus application nano drug delivery system therapy. Keywords: cancer-associated fibroblasts, delivery, nanomedicine, immunotherapy
Язык: Английский
Процитировано
3
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101626 - 101626
Опубликована: Март 1, 2025
Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.
Язык: Английский
Процитировано
3
Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 17, 2025
Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.
Язык: Английский
Процитировано
2
APL Bioengineering, Год журнала: 2025, Номер 9(1)
Опубликована: Март 1, 2025
Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment by promoting growth, immune evasion, and metastasis. Recently, drug delivery systems targeting CAFs have emerged as promising long-term effective approach to cancer treatment. Advances nanotechnology, particular, led development of nanomedicine designed specifically target CAFs, offering new possibilities for precise personalized therapies. This article reviews recent progress using nanocarriers that CAFs. Additionally, we explore potential combining multiple therapies, such chemotherapy immunotherapy, with enhance efficacy overcome resistance. Although many preclinical studies show promise, clinical application still faces considerable challenges, especially terms penetration large-scale production. Therefore, this review aims provide fresh perspective on CAF-targeted highlight future research directions applications.
Язык: Английский
Процитировано
1
Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 564 - 586
Опубликована: Дек. 5, 2024
Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science
Язык: Английский
Процитировано
7
Nanomaterials, Год журнала: 2024, Номер 14(19), С. 1598 - 1598
Опубликована: Окт. 3, 2024
This article explores the emerging field of nanomedicine as a drug delivery system, aimed at enhancing therapeutic efficacy active pharmaceutical ingredients in medicinal plants. The traditional methods applying plants present several limitations, such low bioavailability, poor solubility, challenges accurately controlling dosage, and inadequate targeting. Nanoformulations represent an innovative approach preparation that employs nanotechnology to produce nanoscale particles or carriers, which are designed overcome these limitations. offer distinct advantages, significantly solubility bioavailability drugs, particularly for poorly soluble components These formulations effectively enhance thereby facilitating better absorption utilization by human body, turn improves efficacy. Furthermore, enables targeted delivery, ensuring precise administration lesion site minimizing side effects on healthy tissues. Additionally, nanoformulations can regulate release rates, extend duration action, stability treatment effects. However, certain limitations potential risks; their safety require further investigation, regarding toxicity with long-term use. Nevertheless, nanomaterials demonstrate substantial augmenting plants, offering novel approaches methodologies development application.
Язык: Английский
Процитировано
6
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105938 - 105938
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
4
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104705 - 104705
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2024, Номер 91, С. 102624 - 102624
Опубликована: Ноя. 19, 2024
Язык: Английский
Процитировано
3