Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 28, 2024
Sepsis,
a
severe
and
life-threatening
condition
arising
from
dysfunctional
host
response
to
infection,
presents
considerable
challenges
the
health
care
system
is
characterized
by
high
mortality
rates
substantial
economic
costs.
Exosomes
have
garnered
attention
as
potential
diagnostic
markers
because
of
their
capacity
mirror
pathophysiological
milieu
sepsis.
This
discourse
reviews
progression
sepsis
classification
Sepsis
1.0
3.0,
highlighting
imperative
for
sensitive
specific
biomarkers
facilitate
timely
diagnosis
optimize
patient
outcomes.
Existing
biomarkers,
such
procalcitonin
(PCT)
C-reactive
protein
(CRP),
exhibit
certain
limitations,
thereby
prompting
quest
more
dependable
indicators.
Exosomal
cargoes,
which
encompass
proteins
miRNAs,
present
trove
biomarker
candidates,
attributable
stability,
pervasive
presence,
indicative
nature
disease
status.
The
exosomal
in
identification
sepsis-induced
organ
damage,
including
cardiomyopathy,
acute
kidney
injury,
lung
emphasized,
they
provide
real-time
insights
into
cardiac
renal
impairments.
Despite
promising
prospects,
hurdles
persist
standardization
exosome
extraction
need
extensive
clinical
trials
validate
efficacy.
combination
development
sophisticated
detection
techniques
represents
pioneering
strategy
realm
management,
underscoring
significance
further
research
validation.
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 16, 2025
Multiple
Myeloma
(MM)
is
the
second
most
common
malignancy
of
hematopoietic
system,
accounting
for
approximately
10%
all
hematological
malignancies,
and
currently,
there
no
complete
cure.
Existing
research
indicates
that
exosomal
long
non-coding
RNAs
(lncRNAs)
play
a
crucial
regulatory
role
in
initiation
progression
tumors,
involving
various
interactions
such
as
lncRNA-miRNA,
lncRNA-mRNA,
lncRNA-RNA
binding
proteins
(RBP).
Despite
significant
clinical
application
potential
lncRNAs,
this
area
still
faces
challenges
due
to
their
low
abundance
technical
limitations.
To
our
knowledge,
review
first
comprehensively
integrate
elucidate
three
mechanisms
action
lncRNAs
MM,
propose
therapeutic
targets
cases
based
on
these
mechanisms.
We
highlight
latest
advancements
biomarkers
targets,
offering
not
only
comprehensive
analysis
MM
but
also
new
perspectives
methods
future
diagnosis
treatment
multiple
myeloma.
Biology,
Год журнала:
2025,
Номер
14(1), С. 27 - 27
Опубликована: Янв. 1, 2025
Exosomes
are
small
extracellular
vesicles
and
crucial
in
intercellular
communication.
Interestingly,
tumor-derived
exosomes
carry
oncogenic
molecules,
such
as
proteins
microRNAs,
which
can
reprogram
recipient
cells,
promote
angiogenesis,
stimulate
cancer
pre-metastatic
niche,
supporting
growth
metastasis.
On
the
other
hand,
their
biocompatibility,
stability,
ability
to
cross
biological
barriers
make
them
attractive
candidates
for
drug
delivery.
Recent
advances
have
shown
potential
be
used
early
disease
detection
targeted
therapy
by
delivering
therapeutic
agents
specifically
tumor
sites.
Despite
promising
applications,
a
number
of
challenges
remain,
including
exosome
isolation
characterization,
well
inherent
heterogeneity.
Thus,
current
review
aims
describe
roles
health
disease,
discuss
that
hinder
development
into
becoming
useful
medical
tools.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 6231 - 6252
Опубликована: Июнь 1, 2024
Abstract:
Extracellular
vesicles
(EVs)
are
microparticles
released
from
cells
in
both
physiological
and
pathological
conditions
could
be
used
to
monitor
the
progression
of
various
states,
including
neoplastic
diseases.
In
EVs,
tumor-derived
extracellular
(TEVs)
secreted
by
different
tumor
abundant
many
molecular
components,
such
as
proteins,
nucleic
acids,
lipids,
carbohydrates.
TEVs
play
a
crucial
role
forming
advancing
cancer
processes.
Therefore,
regarded
promising
biomarkers
for
early
detection
liquid
biopsy.
However,
currently
developed
TEV
methods
still
face
several
key
scientific
problems
that
need
solved,
low
sensitivity,
poor
specificity,
accuracy.
To
overcome
these
limitations,
DNA
walkers
have
emerged
one
most
popular
nanodevices
exhibit
better
signal
amplification
capability
enable
highly
sensitive
specific
analytes.
Due
their
unique
properties
high
directionality,
flexibility,
efficiency,
hold
great
potential
detecting
TEVs.
This
paper
provides
an
introduction
EVs
walker,
additionally,
it
summarizes
recent
advances
walker-based
(2018–
2024).
The
review
highlights
close
relationship
between
walkers,
aims
offer
valuable
insights
into
inspire
development
reliable,
efficient,
simple,
innovative
based
on
walker
future.
Keywords:
TEVs,
Abstract
Extracellular
vesicles
(EVs)
composed
of
various
biologically
active
constituents,
such
as
proteins,
nucleic
acids,
lipids,
and
metabolites,
have
emerged
a
noteworthy
mode
intercellular
communication.
There
are
several
categories
EVs,
including
exosomes,
microvesicles,
apoptotic
bodies,
which
largely
differ
in
their
mechanisms
formation
secretion.
The
amount
evidence
indicated
that
changes
the
EV
quantity
composition
play
role
multiple
aspects
cancer
development,
transfer
oncogenic
signals,
angiogenesis,
metabolism
remodeling,
immunosuppressive
effects.
As
isolation
technology
characteristics
recognition
improve,
EVs
becoming
more
commonly
used
early
diagnosis
evaluation
treatment
effectiveness
for
cancers.
Actually,
sparked
clinical
interest
potential
use
delivery
vehicles
or
vaccines
innovative
antitumor
techniques.
This
review
will
focus
on
function
biological
molecules
contained
linked
to
progression
participation
intricate
interrelationship
within
tumor
microenvironment.
Furthermore,
efficacy
an
EV‐based
liquid
biopsy
cargo
be
explored.
Finally,
we
explicitly
delineate
limitations
anticancer
therapies
provide
overview
trials
aimed
at
improving
development.
