
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Май 2, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Май 2, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
7Applied Materials Today, Год журнала: 2024, Номер 41, С. 102471 - 102471
Опубликована: Окт. 13, 2024
Язык: Английский
Процитировано
4Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)
Опубликована: Апрель 1, 2025
ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.
Язык: Английский
Процитировано
0Experimental Hematology and Oncology, Год журнала: 2025, Номер 14(1)
Опубликована: Май 2, 2025
Abstract Hepatocellular carcinoma (HCC) is a primary liver cancer characterized by poor immune cell infiltration and strongly immunosuppressive microenvironment. Traditional treatments have often yielded unsatisfactory outcomes due to the insidious onset of disease. Encouragingly, introduction checkpoint inhibitors (ICIs) has significantly transformed approach HCC treatment. Moreover, combining ICIs with other therapies or novel materials considered most promising opportunity in HCC, some these combinations already being evaluated large-scale clinical trials. Unfortunately, trials fail meet their endpoints, few successful ones also face challenges. This indicates that potential treatment remains underutilized, prompting reevaluation this therapy. Therefore, article provides review role checkpoints treatment, research progress combination application aiming open up avenues for development safer more efficient checkpoint-related strategies Graphical abstract
Язык: Английский
Процитировано
0Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Май 2, 2024
Язык: Английский
Процитировано
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