Identification of a novel mitophagy-related signature for predicting clinical prognosis and immunotherapy of osteosarcoma DOI Creative Commons
Peichuan Xu,

Jiangminghao Zhao,

Wenrui Zhao

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 2, 2024

Abstract Background Osteosarcoma (OS) is a highly aggressive malignancy characterized by poor prognosis. Mitochondrial autophagy (mitophagy) has been implicated in tumor initiation, progression, and response to therapy, highlighting it potential prognostic indicator therapeutic target cancers. Despite this, the precise mechanisms underlying mitophagy osteosarcoma remain enigmatic. This research aims develop mitophagy-associated signature guide strategies prognosis estimations. Methods Clinical transcriptome data for patients with skeletal muscle tissue were retrieved from UCSC Xena GTEx. Mitophagy-related genes (MRGs) obtained Kyoto Encyclopedia of Genes Genomes (KEGG) website. A predictive risk model was constructed using Least Absolute Shrinkage Selection Operator (LASSO) algorithm Cox regression analysis. To delve into fundamental gene expression mechanisms, we employed Gene Ontology (GO), KEGG, Set Enrichment Analysis (GSEA). Moreover, different immune-related activities between two groups investigated ascertain efficacy immunotherapy. Lastly, functional analysis key MRAS carried out via vitro experiments pan-cancer small molecule drugs that may screened through molecular docking. Results Based on seven mitophagy-related signatures, stratified high- low-risk categories. The exhibited strong capability, as evidenced Kaplan-Meier analysis, time-dependent AUC, Nomogram. Notably, compared group, individuals high-risk group lower stromal, immune, estimate scores.The infiltration immune cells decreased. Further evidence supporting MRAS's protective role against shown in vitro, where upregulating its could suppress proliferation, migration, invasion while stimulating their apoptosis. Pan-cancer further demonstrated variety tumors. Conclusion study identified elucidated impact cells. Consequently, opened up fresh avenues clinical prediction established basis precision therapy osteosarcoma.

Язык: Английский

Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review DOI

Fahad Alsaikhan,

Bagher Farhood

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135893 - 135893

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

7
Redox-responsive self-assembled peptide hydrogel for mitochondrial-targeted anticancer drug delivery DOI
Leixia Mei,

Qing Mei,

Weimiao Dong

и другие.

Applied Materials Today, Год журнала: 2024, Номер 41, С. 102471 - 102471

Опубликована: Окт. 13, 2024

Язык: Английский

Процитировано

4
Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery DOI

Razhan Salah Othman,

Sara Zarei,

Hasan Rezaei Haghighat

и другие.

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(4)

Опубликована: Апрель 1, 2025

ABSTRACT Smart polymeric micelles have emerged as versatile nanocarriers in targeted drug delivery, driven by their unique ability to encapsulate therapeutic agents and deliver them with precision specific sites. This review delves into the recent advancements design, functionality, biomedical applications of these nanostructures, emphasizing role enhancing efficacy while minimizing systemic toxicity. The begins discussing principles behind stimuli‐responsive micelles, exploring mechanisms triggered pH, redox conditions, temperature, light achieve controlled release. It highlights advances functionalization strategies, including surface modifications targeting ligands stimuli‐sensitive linkages, which enhance specificity adaptability pathological microenvironments. Subsequent sections focus on cutting‐edge applications, particularly cancer therapy, regenerative medicine, theranostics, showcasing potential addressing complex clinical challenges. Emerging technologies, such multi‐stimuli‐responsive systems hybrid are explored for overcome limitations loading, stability, release profiles. Despite significant progress, current technologies still face challenges, achieving consistent reproducible loading efficiencies, maintaining stability physiological environments, controlling precise kinetics, ensuring scalable cost‐effective production methods. concludes a discussion challenges future perspectives field, need integrating advanced polymer chemistry, nanotechnology, biomedicine develop next‐generation smart micelles. By providing comprehensive overview, this article aims underscore transformative advancing medicine interventions.

Язык: Английский

Процитировано

0
Targeting immune checkpoints in hepatocellular carcinoma therapy: toward combination strategies with curative potential DOI Creative Commons
Jing Tong,

Yongci Tan,

Wenhao Ouyang

и другие.

Experimental Hematology and Oncology, Год журнала: 2025, Номер 14(1)

Опубликована: Май 2, 2025

Abstract Hepatocellular carcinoma (HCC) is a primary liver cancer characterized by poor immune cell infiltration and strongly immunosuppressive microenvironment. Traditional treatments have often yielded unsatisfactory outcomes due to the insidious onset of disease. Encouragingly, introduction checkpoint inhibitors (ICIs) has significantly transformed approach HCC treatment. Moreover, combining ICIs with other therapies or novel materials considered most promising opportunity in HCC, some these combinations already being evaluated large-scale clinical trials. Unfortunately, trials fail meet their endpoints, few successful ones also face challenges. This indicates that potential treatment remains underutilized, prompting reevaluation this therapy. Therefore, article provides review role checkpoints treatment, research progress combination application aiming open up avenues for development safer more efficient checkpoint-related strategies Graphical abstract

Язык: Английский

Процитировано

0
Identification of a novel mitophagy-related signature for predicting clinical prognosis and immunotherapy of osteosarcoma DOI Creative Commons
Peichuan Xu,

Jiangminghao Zhao,

Wenrui Zhao

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Май 2, 2024

Abstract Background Osteosarcoma (OS) is a highly aggressive malignancy characterized by poor prognosis. Mitochondrial autophagy (mitophagy) has been implicated in tumor initiation, progression, and response to therapy, highlighting it potential prognostic indicator therapeutic target cancers. Despite this, the precise mechanisms underlying mitophagy osteosarcoma remain enigmatic. This research aims develop mitophagy-associated signature guide strategies prognosis estimations. Methods Clinical transcriptome data for patients with skeletal muscle tissue were retrieved from UCSC Xena GTEx. Mitophagy-related genes (MRGs) obtained Kyoto Encyclopedia of Genes Genomes (KEGG) website. A predictive risk model was constructed using Least Absolute Shrinkage Selection Operator (LASSO) algorithm Cox regression analysis. To delve into fundamental gene expression mechanisms, we employed Gene Ontology (GO), KEGG, Set Enrichment Analysis (GSEA). Moreover, different immune-related activities between two groups investigated ascertain efficacy immunotherapy. Lastly, functional analysis key MRAS carried out via vitro experiments pan-cancer small molecule drugs that may screened through molecular docking. Results Based on seven mitophagy-related signatures, stratified high- low-risk categories. The exhibited strong capability, as evidenced Kaplan-Meier analysis, time-dependent AUC, Nomogram. Notably, compared group, individuals high-risk group lower stromal, immune, estimate scores.The infiltration immune cells decreased. Further evidence supporting MRAS's protective role against shown in vitro, where upregulating its could suppress proliferation, migration, invasion while stimulating their apoptosis. Pan-cancer further demonstrated variety tumors. Conclusion study identified elucidated impact cells. Consequently, opened up fresh avenues clinical prediction established basis precision therapy osteosarcoma.

Язык: Английский

Процитировано

0