Multifaceted Role of Nanocomposite Hydrogels in Diabetic Wound Healing: Enhanced Biomedical Applications and Detailed Molecular Mechanisms DOI

Gege Xiong,

Qiwei Chen, Qiuyu Wang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.

Language: Английский

Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings DOI Creative Commons

A. S. Alberts,

Dana-Ionela Tudorache,

Adelina-Gabriela Niculescu

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

Citations

7

Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded with Astragalus membranaceus-Panax notoginseng on wound healing in rats DOI Creative Commons
Jing Li,

Linai Li,

Yue Yu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Skin wound healing is a complex physiological process that involves many different cell types and signaling molecules. In traditional Chinese medicine, A. membranaceus Panax notoginseng are commonly used together for the treatment of injury their significant efficacy. The application new materials may make -P. (AP) play better curative effect. this study, we fabricated Carboxymethyl chitosan-Sodium alginate hydrogel loaded with extract Astragalus - P. (APCS), which showed favorable stability, biocompatibility, ability to rapidly release drugs. Cell culture experiments demonstrated APCS dramatically increased fibroblast proliferation, migration, differentiation into myofibroblast. vivo on SD rats hydrogels significantly accelerated skin healing, reduced inflammatory response, enhanced formation blood vessels, granulation tissues, collagen fibers, promoted re-epithelialization at site. Increased expression catalase, VEGF, PGP9.5 tissue indicated inhibited oxidative stress vascular neuronal regeneration. summary, displayed great potential as dressing achieving satisfactory full-thickness wounds.

Language: Английский

Citations

1

Exploring the therapeutic potential of ligand-decorated nanostructured lipid carriers for targeted solid tumor therapy DOI

Zrien Naz,

Mohammad Fareed,

Abdur Rahman Hamidullah Chaudhary

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 678, P. 125687 - 125687

Published: May 9, 2025

Language: Английский

Citations

0

Mechanistic Wound Healing of Ficus trijuja Leaf Extract and Its Lipid Nanocapsule Supported by Metabolomic Profiling and In Vivo Studies DOI Open Access
Ingy M. Hashad, Shaza H. Aly, Dalia O. Saleh

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 928 - 928

Published: Jan. 23, 2025

This study explores the metabolic profile and wound-healing capabilities of Ficus trijuja, a species within Moraceae family, for first time. plants contain variety secondary metabolites such as flavonoids, triterpenoids, alkaloids, known their antioxidant, anti-inflammatory, cytotoxic properties. Previous studies demonstrated effectiveness extracts in wound healing, with evidence improved contraction, strength, faster epithelization. shows impact F. trijuja extract gel base well when delivered through lipid nanocapsules (LNCs) formula, on all phases rats, by determining expression levels key markers. The results indicated that treatment accelerated particularly applied nanocapsulation, which comparable efficacy to standard treatments like MEBO® approximately 2.62% improvement healing compared itself. Understanding these molecular markers offers insights developing targeted therapies optimize prevent complication development. To unravel phytochemical composition extract, LC-HRESIMS analysis was implemented, revealed 24 belonging different classes terpenoids, megastigmane. In conclusion, both its nanoformulation have proven vivo can be further investigated potential clinical use.

Language: Английский

Citations

0

Polymer‐ and Lipid‐Based Nanostructures Serving Wound Healing Applications: A Review DOI
Fatma Nalan Cetin, Arn Mignon, Sandra Van Vlierberghe

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract Management of hard‐to‐heal wounds often requires specialized care that surpasses the capabilities conventional treatments. Even most advanced commercial products lack functionality to meet needs wounds, especially those complicated by active infection, extreme bleeding, and chronic inflammation. The review explores how supramolecular nanovesicles nanoparticles—such as dendrimers, micelles, polymersomes, lipid‐based nanocarriers—can be key introducing wound healing monitoring properties address complex wounds. Their potential enable functions essential for next‐generation products—such hemostatic functions, transdermal penetration, macrophage polarization, targeted delivery, controlled release pharmaceutical ingredients (antibiotics, gaseous products, anti‐inflammatory drugs, growth factors)—is discussed via an extensive overview recent reports. These studies highlight integration systems in is crucial advancing toward a new generation addressing significant gaps current management practices. Current strategies improvements regarding personalized therapies, promising critically evaluated but underexplored polymer‐based nanovesicles, including polymersomes proteinosomes, healing.

Language: Английский

Citations

2

Tacrolimus: Physicochemical stability challenges, analytical methods, and new formulations DOI Creative Commons

Sara Sajjadi,

Ali Shayanfar,

Farhad Kiafar

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100285 - 100285

Published: Sept. 15, 2024

Language: Английский

Citations

1

Contemporary strategies in glioblastoma therapy: Recent developments and innovations DOI

Mariya Khan,

Modassir Nasim,

Mohammadamin Feizy

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0

Multifaceted Role of Nanocomposite Hydrogels in Diabetic Wound Healing: Enhanced Biomedical Applications and Detailed Molecular Mechanisms DOI

Gege Xiong,

Qiwei Chen, Qiuyu Wang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.

Language: Английский

Citations

0