Foods,
Год журнала:
2023,
Номер
12(6), С. 1143 - 1143
Опубликована: Март 8, 2023
Traditionally
made
doenjang
(TMD)
produced
by
the
long-term
fermentation
of
soybeans
with
salt
may
improve
symptoms
estrogen
deficiency.
We
aimed
to
evaluate
effects
four
TMD
types,
containing
low
and
high
amounts
Bacillus
species
biogenic
amines
(HBHA,
HBLA,
LBHA,
LBLA),
on
energy,
glucose,
lipid
metabolism,
altering
gut
microbiota
in
estrogen-deficient
ovariectomized
(OVX)
rats.
Their
mechanisms
were
also
examined.
The
OVX
rats
divided
into
control,
cooked
soybean
(CSB),
HBHA,
LBLA
groups.
Sham-operated
normal
control
group.
Serum
17β-estradiol
concentrations
similar
among
all
Tail
skin
temperatures,
which
are
indicative
hot
flashes,
higher
than
HBHA
HBLA
groups
Weight
gain
visceral
fat
mass
lower
CSB
intake
but
not
as
Lean
body
showed
a
trend
opposite
that
respective
hepatic
triglyceride
content
decreased
compared
mRNA
expressions
peroxisome
proliferator-activated
receptor-γ
(PPAR-γ)
carnitine
palmitoyltransferase-1
group,
PPAR-γ
expression
was
more
elevated
group
morphology
intestines
improved
an
enhanced
improvement
LBHA
increased
α-diversity
cecal
control.
Akkermenia
Lactobacillus
estrogen,
forkhead
box
proteins
class-O
subgroup,
insulin-signaling
pathways
prevented
their
decrement.
In
conclusion,
treatment
potentially
improves
deficiency
unfermented
soybeans.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6566 - 6566
Опубликована: Март 31, 2023
Early
and
premature
menopause,
or
ovarian
insufficiency
(POI),
affects
1%
of
women
under
the
age
40
years.
This
paper
reviews
main
aspects
early
menopause
their
impact
on
cognitive
decline.
Based
literature,
complaints
are
more
common
near
menopause:
a
phase
marked
by
decrease
in
hormone
levels,
especially
estrogen.
A
reduction
estrogen
puts
at
higher
risk
for
cardiovascular
disease,
parkinsonism,
depression,
osteoporosis,
hypertension,
weight
gain,
midlife
diabetes,
as
well
disorders
dementia,
such
Alzheimer's
disease
(AD).
Experimental
epidemiological
studies
suggest
that
female
sex
hormones
have
long-lasting
neuroprotective
anti-aging
properties.
Estrogens
seem
to
prevent
arising
from
cholinergic
deficit
animals
middle
central
nervous
system
(CNS)
directly
indirectly,
both
transiently
long
term,
leads
impairment
even
mainly
due
levels
comorbidity
with
factors,
autoimmune
diseases,
aging.
Menopausal
therapy
60
years
may
provide
"window
opportunity"
reduce
mild
(MCI)
AD
later
life.
Women
earlier
should
be
taken
care
various
specialists
gynecologists,
endocrinologists,
neurologists,
psychiatrists
order
maintain
mental
health
highest
possible
level.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Март 17, 2023
Dysbiosis
characterises
breast
cancer
through
direct
or
indirect
interference
in
a
variety
of
biological
pathways;
therefore,
specific
microbial
patterns
and
diversity
may
be
biomarker
for
the
diagnosis
prognosis
cancer.
However,
there
is
still
much
to
determine
about
complex
interplay
gut
microbiome
cancer.This
study
aims
evaluate
alteration
patients
compared
with
control
subjects,
explore
intestine
modification
from
range
different
treatments,
identify
impact
on
same
treatment-receiving
patients.A
literature
search
was
conducted
using
electronic
databases
such
as
PubMed,
Embase,
CENTRAL
up
April
2021.
The
limited
adult
women
English
language.
results
were
synthesised
qualitatively
quantitatively
random-effects
meta-analysis.A
total
33
articles
32
studies
included
review,
representing
19
case-control,
eight
cohorts,
five
nonrandomised
intervention
researches.
bacterial
species
elevated
cases
tumours,
significant
increase
Methylobacterium
radiotolerans
(p
=
0.015),
healthy
tissue.
Meta-analysis
α-diversity
indexes
Shannon
index
0.0005),
observed
0.006),
faint's
phylogenetic
<
0.00001)
revealed
low
intestinal
microbiota
abundance
pattern
identified
sample
types,
detection
methods,
menopausal
status,
nationality,
obesity,
sleep
quality,
several
interventions
qualitative
analysis.This
systematic
review
elucidates
network
microbiome,
cancer,
therapeutic
options,
objective
providing
link
stronger
research
towards
personalised
medicine
improve
their
quality
life.
Cell Host & Microbe,
Год журнала:
2024,
Номер
32(6), С. 925 - 944.e10
Опубликована: Май 15, 2024
Hormones
and
neurotransmitters
are
essential
to
homeostasis,
their
disruptions
connected
diseases
ranging
from
cancer
anxiety.
The
differential
reactivation
of
endobiotic
glucuronides
by
gut
microbial
β-glucuronidase
(GUS)
enzymes
may
influence
interindividual
differences
in
the
onset
treatment
disease.
Using
multi-omic,
vitro,
vivo
approaches,
we
show
that
germ-free
mice
have
reduced
levels
active
endobiotics
distinct
Loop
1
FMN
GUS
drive
hormone
neurotransmitter
reactivation.
We
demonstrate
a
range
FDA-approved
drugs
prevent
this
intercepting
catalytic
cycle
conserved
fashion.
Finally,
find
inhibiting
conventional
reduces
free
serotonin
increases
its
inactive
glucuronide
serum
intestines.
Our
results
illuminate
indispensability
sustaining
homeostasis
indicate
therapeutic
metabolism
promote
response
variabilities.
Microbial Biotechnology,
Год журнала:
2024,
Номер
17(4)
Опубликована: Апрель 1, 2024
Abstract
Alzheimer's
disease
is
a
complex
and
progressive
condition
that
affects
essential
neurological
functions
such
as
memory
reasoning.
In
the
brain,
neuronal
loss,
synaptic
dysfunction,
proteinopathy,
neurofibrillary
tangles,
neuroinflammation
are
hallmarks
of
pathophysiology.
addition,
recent
evidence
has
highlighted
microbes,
whether
commensal
or
pathogenic,
also
have
ability
to
interact
with
their
host
regulate
its
immune
system,
therefore
participating
in
exchanges
lead
peripheral
inflammation
neuropathology.
Because
this
intimate
relationship,
bacteria,
viruses,
fungi,
protozoa
been
implicated
development
disease.
Here,
we
bring
together
current
most
role
microbes
disease,
raising
burning
questions
need
be
addressed
guide
therapeutic
approaches
potential
prophylactic
strategies.
Applied Sciences,
Год журнала:
2025,
Номер
15(2), С. 522 - 522
Опубликована: Янв. 8, 2025
The
health-promoting,
preventive,
protective,
and
therapeutic
applications
of
the
natural
compound
sulforaphane
(SF)
produced
from
its
biogenic
precursor
in
broccoli,
glucoraphanin,
are
extremely
well
established.
SF
has
been
subject
thousands
studies
over
125
clinical
trials.
many
mechanisms
action
mammalian
systems
have
extensively
documented.
is
most
potent
naturally
occurring
inducer
Keap1/Nrf2
pathway,
which
well-known
for
upregulation
antioxidant
detoxification
activation
pathways
resulting
inhibition
inflammation.
Much
this
regulation
involves
various
hormonal
axes
body.
However,
influence
on
hormone-mediated
health
conditions
remains
unexplored
recent
scholarly
reviews.
This
review
aims
to
address
gap
by
exploring
these
interactions,
with
a
focus
wellness
issues
specific
both
females
males.
Women
suffer
from
various
distress
and
disturbances
after
menopause,
including
osteoporosis,
a
risk
factor
associated
with
multiple
diseases.
Altered
gut
microbiota
has
been
implicated
in
postmenopausal
osteoporosis.
In
this
study,
to
understand
signatures
fecal
metabolite
changes
women
108
were
recruited
for
intestinal
detection.
Among
these
participants,
98
patients,
who
met
the
inclusion
criteria,
divided
into
osteoporosis
(PMO)
non-postmenopausal
(non-PMO)
groups
based
on
bone
mineral
density
(BMD).
The
compositions
of
bacteria
fungi
examined
by
16
S
rRNA
gene
sequencing
ITS
sequencing,
respectively.
Meanwhile,
metabolites
analyzed
using
liquid
chromatography
coupled
mass
spectrometry
(LC-MS).We
found
that
bacterial
α-diversity
β-diversity
significantly
altered
PMO
compared
non-PMO
patients.
Interestingly,
composition
showed
larger
changes,
differences
more
significant
between
Metabolomics
analysis
revealed
metabolites,
such
as
levulinic
acid,
N-Acetylneuraminic
corresponding
signaling
pathways
also
changed
significantly,
especially
alpha-Linolenic
acid
metabolism
selenocompound
metabolism.
screened
differential
bacteria,
fungi,
closely
correlated
clinical
findings
two
groups,
example,
genus,
Fusobacterium,
fungal
Devriesia,
metabolite,
L-pipecolic
BMD.Our
indicated
there
remarkable
women,
notably
patients'
BMD
and
findings.
These
correlations
provide
novel
insights
mechanism
development,
potential
early
diagnostic
indicators,
new
therapeutic
approaches
improve
health
women.
Pathophysiology,
Год журнала:
2024,
Номер
31(3), С. 309 - 330
Опубликована: Июнь 21, 2024
Understanding
how
gut
flora
interacts
with
oxidative
stress
has
been
the
subject
of
significant
research
in
recent
years.
There
is
much
evidence
demonstrating
existence
microbiome–oxidative
interaction.
However,
biochemical
basis
this
interaction
still
unclear.
In
narrative
review,
possible
pathways
microbiota
and
are
presented,
among
which
genetic
underpinnings
play
an
important
role.
Trimethylamine-N-oxide,
mitochondria,
short-chain
fatty
acids,
melatonin
also
appear
to
roles.
Moreover,
relationship
between
microbiome
obesity,
metabolic
syndrome,
chronic
ethanol
consumption,
dietary
supplements,
medications
considered.
An
investigation
correlation
bacterial
community
features
OS
parameter
changes
under
normal
pathological
conditions
might
provide
information
for
determination
new
methods.
Furthermore,
such
could
contribute
establishing
a
foundation
determining
linkers
microbiome–OS
association.
Alzheimer s Research & Therapy,
Год журнала:
2024,
Номер
16(1)
Опубликована: Май 20, 2024
Abstract
Background
The
gut-derived
metabolite
Trimethylamine
N-oxide
(TMAO)
and
its
precursors
-
betaine,
carnitine,
choline,
deoxycarnitine
–
have
been
associated
with
an
increased
risk
of
cardiovascular
disease,
but
their
relation
to
cognition,
neuroimaging
markers,
dementia
remains
uncertain.
Methods
In
the
population-based
Rotterdam
Study,
we
used
multivariable
regression
models
study
associations
between
plasma
TMAO,
precursors,
cognition
in
3,143
participants.
Subsequently,
examined
link
structural
brain
MRI
markers
2,047
participants,
a
partial
validation
Leiden
Longevity
Study
(
n
=
318).
Among
2,517
assessed
incident
using
Cox
proportional
hazard
models.
Following
this,
stratified
longitudinal
by
medication
use
sex,
after
which
conducted
sensitivity
analysis
for
individuals
impaired
renal
function.
Results
Overall,
TMAO
was
not
or
dementia.
Instead,
higher
choline
significantly
poor
(adjusted
mean
difference:
-0.170
[95%
confidence
interval
(CI)
-0.297;-0.043]),
atrophy
more
cerebral
small
vessel
such
as
white
matter
hyperintensity
volume
(0.237
CI:
0.076;0.397]).
By
contrast,
carnitine
concurred
lower
(-0.177
-0.343;-0.010]).
Only
among
function,
appeared
increase
(hazard
ratio
(HR):
1.73
1.16;2.60]).
No
notable
differences
were
observed
analyses.
Conclusions
Plasma
opposed
found
be
cognitive
decline,
atrophy,
disease.
These
findings
illustrate
complexity
relationships
emphasize
need
concurrent
elucidate
gut-brain
mechanisms.
