Improvement of Estrogen Deficiency Symptoms by the Intake of Long-Term Fermented Soybeans (Doenjang) Rich in Bacillus Species through Modulating Gut Microbiota in Estrogen-Deficient Rats DOI Creative Commons
Ting Zhang, Yue Yu, Su-Ji Jeong

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(6), P. 1143 - 1143

Published: March 8, 2023

Traditionally made doenjang (TMD) produced by the long-term fermentation of soybeans with salt may improve symptoms estrogen deficiency. We aimed to evaluate effects four TMD types, containing low and high amounts Bacillus species biogenic amines (HBHA, HBLA, LBHA, LBLA), on energy, glucose, lipid metabolism, altering gut microbiota in estrogen-deficient ovariectomized (OVX) rats. Their mechanisms were also examined. The OVX rats divided into control, cooked soybean (CSB), HBHA, LBLA groups. Sham-operated normal control group. Serum 17β-estradiol concentrations similar among all Tail skin temperatures, which are indicative hot flashes, higher than HBHA HBLA groups Weight gain visceral fat mass lower CSB intake but not as Lean body showed a trend opposite that respective hepatic triglyceride content decreased compared mRNA expressions peroxisome proliferator-activated receptor-γ (PPAR-γ) carnitine palmitoyltransferase-1 group, PPAR-γ expression was more elevated group morphology intestines improved an enhanced improvement LBHA increased α-diversity cecal control. Akkermenia Lactobacillus estrogen, forkhead box proteins class-O subgroup, insulin-signaling pathways prevented their decrement. In conclusion, treatment potentially improves deficiency unfermented soybeans.

Language: Английский

Cognitive Decline in Early and Premature Menopause DOI Open Access
Marta Sochocka, Julia Karska, Magdalena Pszczołowska

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6566 - 6566

Published: March 31, 2023

Early and premature menopause, or ovarian insufficiency (POI), affects 1% of women under the age 40 years. This paper reviews main aspects early menopause their impact on cognitive decline. Based literature, complaints are more common near menopause: a phase marked by decrease in hormone levels, especially estrogen. A reduction estrogen puts at higher risk for cardiovascular disease, parkinsonism, depression, osteoporosis, hypertension, weight gain, midlife diabetes, as well disorders dementia, such Alzheimer's disease (AD). Experimental epidemiological studies suggest that female sex hormones have long-lasting neuroprotective anti-aging properties. Estrogens seem to prevent arising from cholinergic deficit animals middle central nervous system (CNS) directly indirectly, both transiently long term, leads impairment even mainly due levels comorbidity with factors, autoimmune diseases, aging. Menopausal therapy 60 years may provide "window opportunity" reduce mild (MCI) AD later life. Women earlier should be taken care various specialists gynecologists, endocrinologists, neurologists, psychiatrists order maintain mental health highest possible level.

Language: Английский

Citations

52
Human gut, breast, and oral microbiome in breast cancer: A systematic review and meta-analysis DOI Creative Commons
May Soe Thu, Korn Chotirosniramit, Tanawin Nopsopon

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: March 17, 2023

Dysbiosis characterises breast cancer through direct or indirect interference in a variety of biological pathways; therefore, specific microbial patterns and diversity may be biomarker for the diagnosis prognosis cancer. However, there is still much to determine about complex interplay gut microbiome cancer.This study aims evaluate alteration patients compared with control subjects, explore intestine modification from range different treatments, identify impact on same treatment-receiving patients.A literature search was conducted using electronic databases such as PubMed, Embase, CENTRAL up April 2021. The limited adult women English language. results were synthesised qualitatively quantitatively random-effects meta-analysis.A total 33 articles 32 studies included review, representing 19 case-control, eight cohorts, five nonrandomised intervention researches. bacterial species elevated cases tumours, significant increase Methylobacterium radiotolerans (p = 0.015), healthy tissue. Meta-analysis α-diversity indexes Shannon index 0.0005), observed 0.006), faint's phylogenetic < 0.00001) revealed low intestinal microbiota abundance pattern identified sample types, detection methods, menopausal status, nationality, obesity, sleep quality, several interventions qualitative analysis.This systematic review elucidates network microbiome, cancer, therapeutic options, objective providing link stronger research towards personalised medicine improve their quality life.

Language: Английский

Citations

26
Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics DOI Creative Commons
Joshua B. Simpson, Morgan E. Walker,

Joshua J. Sekela

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(6), P. 925 - 944.e10

Published: May 15, 2024

Hormones and neurotransmitters are essential to homeostasis, their disruptions connected diseases ranging from cancer anxiety. The differential reactivation of endobiotic glucuronides by gut microbial β-glucuronidase (GUS) enzymes may influence interindividual differences in the onset treatment disease. Using multi-omic, vitro, vivo approaches, we show that germ-free mice have reduced levels active endobiotics distinct Loop 1 FMN GUS drive hormone neurotransmitter reactivation. We demonstrate a range FDA-approved drugs prevent this intercepting catalytic cycle conserved fashion. Finally, find inhibiting conventional reduces free serotonin increases its inactive glucuronide serum intestines. Our results illuminate indispensability sustaining homeostasis indicate therapeutic metabolism promote response variabilities.

Language: Английский

Citations

14
Do microbes play a role in Alzheimer's disease? DOI Creative Commons
Zoë Williams, Léonie Láng, Sarah Nicolas

et al.

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(4)

Published: April 1, 2024

Abstract Alzheimer's disease is a complex and progressive condition that affects essential neurological functions such as memory reasoning. In the brain, neuronal loss, synaptic dysfunction, proteinopathy, neurofibrillary tangles, neuroinflammation are hallmarks of pathophysiology. addition, recent evidence has highlighted microbes, whether commensal or pathogenic, also have ability to interact with their host regulate its immune system, therefore participating in exchanges lead peripheral inflammation neuropathology. Because this intimate relationship, bacteria, viruses, fungi, protozoa been implicated development disease. Here, we bring together current most role microbes disease, raising burning questions need be addressed guide therapeutic approaches potential prophylactic strategies.

Language: Английский

Citations

10
The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review DOI Creative Commons
Jed W. Fahey,

Mirran Raphaely

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 522 - 522

Published: Jan. 8, 2025

The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been subject thousands studies over 125 clinical trials. many mechanisms action mammalian systems have extensively documented. is most potent naturally occurring inducer Keap1/Nrf2 pathway, which well-known for upregulation antioxidant detoxification activation pathways resulting inhibition inflammation. Much this regulation involves various hormonal axes body. However, influence on hormone-mediated health conditions remains unexplored recent scholarly reviews. This review aims to address gap by exploring these interactions, with a focus wellness issues specific both females males.

Language: Английский

Citations

1
Menopausal shift on women’s health and microbial niches DOI Creative Commons
Maria Nieto, Maria J. Rus, Victoria Areal‐Quecuty

et al.

npj Women s Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 14, 2025

Language: Английский

Citations

1
Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis DOI Creative Commons
Han Wang, Jing Liu,

Zuoxing Wu

et al.

Gut Pathogens, Journal Year: 2023, Volume and Issue: 15(1)

Published: July 6, 2023

Women suffer from various distress and disturbances after menopause, including osteoporosis, a risk factor associated with multiple diseases. Altered gut microbiota has been implicated in postmenopausal osteoporosis. In this study, to understand signatures fecal metabolite changes women 108 were recruited for intestinal detection. Among these participants, 98 patients, who met the inclusion criteria, divided into osteoporosis (PMO) non-postmenopausal (non-PMO) groups based on bone mineral density (BMD). The compositions of bacteria fungi examined by 16 S rRNA gene sequencing ITS sequencing, respectively. Meanwhile, metabolites analyzed using liquid chromatography coupled mass spectrometry (LC-MS).We found that bacterial α-diversity β-diversity significantly altered PMO compared non-PMO patients. Interestingly, composition showed larger changes, differences more significant between Metabolomics analysis revealed metabolites, such as levulinic acid, N-Acetylneuraminic corresponding signaling pathways also changed significantly, especially alpha-Linolenic acid metabolism selenocompound metabolism. screened differential bacteria, fungi, closely correlated clinical findings two groups, example, genus, Fusobacterium, fungal Devriesia, metabolite, L-pipecolic BMD.Our indicated there remarkable women, notably patients' BMD ​​and findings. These correlations provide novel insights mechanism development, potential early diagnostic indicators, new therapeutic approaches improve health women.

Language: Английский

Citations

20
Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health DOI Creative Commons
Н. В. Семенова, N.E. Garashchenko, С. И. Колесников

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 309 - 330

Published: June 21, 2024

Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating existence microbiome–oxidative interaction. However, biochemical basis this interaction still unclear. In narrative review, possible pathways microbiota and are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, melatonin also appear to roles. Moreover, relationship between microbiome obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, medications considered. An investigation correlation bacterial community features OS parameter changes under normal pathological conditions might provide information for determination new methods. Furthermore, such could contribute establishing a foundation determining linkers microbiome–OS association.

Language: Английский

Citations

7
Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia DOI Creative Commons
Amber Yaqub, Dina Vojinović, Meike W. Vernooij

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 20, 2024

Abstract Background The gut-derived metabolite Trimethylamine N-oxide (TMAO) and its precursors - betaine, carnitine, choline, deoxycarnitine – have been associated with an increased risk of cardiovascular disease, but their relation to cognition, neuroimaging markers, dementia remains uncertain. Methods In the population-based Rotterdam Study, we used multivariable regression models study associations between plasma TMAO, precursors, cognition in 3,143 participants. Subsequently, examined link structural brain MRI markers 2,047 participants, a partial validation Leiden Longevity Study ( n = 318). Among 2,517 assessed incident using Cox proportional hazard models. Following this, stratified longitudinal by medication use sex, after which conducted sensitivity analysis for individuals impaired renal function. Results Overall, TMAO was not or dementia. Instead, higher choline significantly poor (adjusted mean difference: -0.170 [95% confidence interval (CI) -0.297;-0.043]), atrophy more cerebral small vessel such as white matter hyperintensity volume (0.237 CI: 0.076;0.397]). By contrast, carnitine concurred lower (-0.177 -0.343;-0.010]). Only among function, appeared increase (hazard ratio (HR): 1.73 1.16;2.60]). No notable differences were observed analyses. Conclusions Plasma opposed found be cognitive decline, atrophy, disease. These findings illustrate complexity relationships emphasize need concurrent elucidate gut-brain mechanisms.

Language: Английский

Citations

5
Can probiotics decrease the risk of postmenopausal osteoporosis in women? DOI
Iskandar Azmy Harahap, Joanna Suliburska

PharmaNutrition, Journal Year: 2023, Volume and Issue: 24, P. 100336 - 100336

Published: March 9, 2023

Language: Английский

Citations

12