Obesity and Dyslipidemia: A Review of Current Evidence

Current Obesity Reports, Год журнала: 2023, Номер 12(3), С. 207 - 222

Опубликована: Июль 6, 2023

Язык: Английский

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PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome

EBioMedicine, Год журнала: 2023, Номер 89, С. 104492 - 104492

Опубликована: Март 1, 2023

Язык: Английский

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Multimorbidität bei endokrinologischen Erkrankungen: Klinische Implikationen des PCOS

DMW - Deutsche Medizinische Wochenschrift, Год журнала: 2025, Номер 150(09), С. 496 - 502

Опубликована: Апрель 1, 2025

Polycystic ovary syndrome (PCOS) is one of the most common endocrinological disorders in women reproductive age. It affects up to 15% this population worldwide and characterized by a complex hormonal, metabolic dysfunction. In article, multimorbidity PCOS reviewed, with particular focus on clinical implications management disorder.

Язык: Английский

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The Anti-Mullerian Hormone as a Biomarker of Effectiveness of Metformin Hydrochloride Therapy in Polycystic Ovarian Syndrome and Insulin Resistance

Healthcare, Год журнала: 2025, Номер 13(8), С. 884 - 884

Опубликована: Апрель 11, 2025

Background/Objectives: Among the therapeutic options available for managing PCOS, metformin improves insulin sensitivity, reduces androgen levels, and helps restore menstrual regularity ovulation. While primarily used its metabolic effects, therapy may also influence reproductive parameters, including AMH which are pivotal in improving ovarian function predicting outcomes PCOS. The aim of this study was to search scientific literature analyze correlation between levels hydrochloride women with PCOS IR. Methods: A systematic review conducted using following keywords: polycystic syndrome, anti-Mullerian hormone, resistance, metformin, treatment, biomarker, syndrome. This aimed at investigating potential as a biomarker effectiveness patients Results: Metformin treatment has shown significant reductions serum prolonged therapy. As an sensitizer, hyperinsulinemia, suppresses hyperandrogenism. process inhibits growth antral follicles, is reflected decreased levels. Conclusions: Reductions improvements sensitivity can serve indicators efficacy enhancements these patients. could be considered prognostic marker evaluating decrease indicate improved reduction morphology. However, further research necessary confirm findings determine optimal dosages duration treatment.

Язык: Английский

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Probiotic therapy, a novel and efficient adjuvant approach to improve glycemic status: An umbrella meta-analysis

Pharmacological Research, Год журнала: 2022, Номер 183, С. 106397 - 106397

Опубликована: Авг. 15, 2022

Язык: Английский

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Combined oral contraceptive pill compared with no medical treatment in the management of polycystic ovary syndrome: A systematic review

Clinical Endocrinology, Год журнала: 2023, Номер 99(1), С. 79 - 91

Опубликована: Март 20, 2023

Abstract Objective As part of the update International Evidence‐Based Guidelines for Assessment and Management polycystic ovary syndrome (PCOS), a systematic review was performed to inform evidence‐based recommendations. Design Systematic review. Only randomised controlled trial were included. Patients Women with PCOS; use combined oral contraceptive pills (COCP) compared no medical treatment. Measurements Outcomes designed in collaboration clinical experts, researchers, consumers. Critical outcomes included hirsutism, irregular cycles, quality life, body mass index (BMI), weight. Results 1660 publications identified, but only four studies No could be meta‐analysis. COCP treatment improved cycle regularity (100% vs. 0%, low certainty evidence). showed difference improvement hirsutism or BMI placebo lifestyle; lower weight after (mean [MD] −8.0 (95% confidence interval, CI −11.67); −4.33 kg); life (MD 1.2 [95% 0.96]; 1.44), these results all very evidence. Conclusion show that benefit regulation, other benefits potential adverse effects identified The is frontline PCOS, this still based on established efficacy broader general population. Our research PCOS seriously lacking should prioritised capture core reproductive, metabolic psychological important PCOS.

Язык: Английский

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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice: Compared Evaluation of Liraglutide and Semaglutide Intervention

Diabetes Metabolic Syndrome and Obesity, Год журнала: 2024, Номер Volume 17, С. 865 - 880

Опубликована: Фев. 1, 2024

Purpose: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility in reproductive-age women. Our work aims to evaluate the effects glucagon-like peptide-1 receptor agonists (GLP-1RAs) on gut microbiota, with metabolic parameters including body weight and hormone profile PCOS. Patients Methods: Dehydroepiandrosterone (DHEA)-induced PCOS mice were established then treated two GLP-1RAs: liraglutide novel form semaglutide for four weeks. Changes measured. Fecal samples collected analyzed using metagenomic sequencing. Results: Liraglutide modulated both alpha beta diversity microbiota increased Bacillota-to-Bacteroidota ratio through up-regulating abundance butyrate-producing members Bacillota like Lachnospiraceae. Moreover, showed ability reverse altered microbial composition disrupted functions caused by Semaglutide Helicobacter (p < 0.01) which was only bacteria found negatively correlated weight. pathways involving porphyrin flavonoids after intervention. Conclusion: improved reproductive disorders modulating whole structure The greater efficacy loss compared observed intervention positively related . study may provide new ideas treatment underlying mechanisms GLP-1RAs improve Keywords: PCOS, GLP-1 agonists, metabolism

Язык: Английский

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Approach to Investigation of Hyperandrogenism in a Postmenopausal Woman

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2022, Номер 108(5), С. 1243 - 1253

Опубликована: Ноя. 21, 2022

Abstract Postmenopausal hyperandrogenism is a condition caused by relative or absolute androgen excess originating from the ovaries and/or adrenal glands. Hirsutism, in other words, increased terminal hair growth androgen-dependent areas of body, considered most effective measure women. Other symptoms can be acne and androgenic alopecia development virilization, including clitoromegaly. may also associated with metabolic disorders such as abdominal obesity, insulin resistance, type 2 diabetes. Mild hyperandrogenic due to menopausal transition polycystic ovary syndrome, which likely common cause postmenopausal hyperandrogenism. Virilizing symptoms, on hand, ovarian hyperthecosis an androgen-producing tumor that could malignant. Determination serum testosterone, preferably tandem mass spectrometry, first step endocrine evaluation, providing important information degree excess. Testosterone &gt;5 nmol/L virilization requires prompt investigation rule out instance. To localize source excess, imaging techniques are used, transvaginal ultrasound magnetic resonance (MRI) for computed tomography MRI adrenals. Bilateral oophorectomy surgical removal main curative treatment will ultimately lead histopathological diagnosis. moderate treated antiandrogen therapy specific depending This review summarizes relevant causes women suggests principles clinical treatment.

Язык: Английский

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Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 166, С. 115327 - 115327

Опубликована: Авг. 22, 2023

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age, characterized by androgen-induced oxidative stress leading to several metabolic disorders. In this study, we investigated the potential therapeutic effect caffeic acid on PCOS and its underlying molecular mechanism. We used human ovarian granulosa cell line (KGN cells) induced hydrogen peroxide (H2O2) examine how influences protein expression stress-induced apoptosis-related markers. Our results indicate significantly inhibits intracellular reactive oxygen species (ROS) generation safeguards KGN cells against stress. For in vivo aspect our female Sprague-Dawley (SD) rats were utilized induce model using dehydroepiandrosterone (DHEA). Caffeic was then administered for duration 6 weeks. The outcomes revealed effectively improved irregular estrous cycles, fasting blood glucose levels, liver function, lipid profiles DHEA-induced rats. Additionally, it mitigated hyperandrogenism, enhanced steroidogenesis enzyme expression, modulated expression. findings strongly suggest holds promising reducing damage ameliorating PCOS-related complications modulating ER

Язык: Английский

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Androgen signalling in the ovaries and endometrium

Molecular Human Reproduction, Год журнала: 2023, Номер 29(6)

Опубликована: Май 12, 2023

Abstract Currently, our understanding of hormonal regulation within the female reproductive system is largely based on knowledge estrogen and progesterone signalling. However, while important functions androgens in male physiology are well known, it also recognized that play critical roles system. Further, androgen signalling altered a variety gynaecological conditions, including endometriosis polycystic ovary syndrome, indicative regulatory endometrial ovarian function. Co-regulatory mechanisms exist between different androgens, estrogens, progesterone, resulting complex network steroid hormone interactions. Evidence from animal knockout studies, vitro experiments, human data indicate receptor expression cell-specific menstrual cycle stage-dependent, with cycle, biology, follicular development ovaries. This review will discuss co-regulatory interactions receptors, highlighting complexity pathway endometrium ovaries, synthesis additional alternative pathways previously disregarded as male-specific. Moreover, illustrate challenges faced when studying need for more in-depth, integrative view metabolism

Язык: Английский

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