Journal of Diabetes & Metabolic Disorders, Год журнала: 2024, Номер 24(1)
Опубликована: Дек. 28, 2024
Язык: Английский
Gut Pathogens, Год журнала: 2023, Номер 15(1)
Опубликована: Март 6, 2023
Parkinson's disease (PD) is the second most common neurodegenerative worldwide. Gut dysbiosis hypothesized to cause PD; therefore, whether probiotics can be used as adjuvants in treatment of PD being actively investigated.We performed a systematic review and meta-analysis evaluate effectiveness probiotic therapy patients.PUBMED/MEDLINE, EMBASE, Cochrane, Scopus, PsycINFO Web Science databases were searched till February 20, 2023. The random effects model effect size was calculated mean difference or standardized difference. We assessed quality evidence using Grade Recommendations Assessment, Development Evaluation (GRADE) approach.Eleven studies involving 840 participants included final analysis. This showed high-quality improvement Unified Rating Scale Part III motor scale (standardized [95% confidence interval]) (- 0.65 [- 1.11 - 0.19]), non-motor symptom 0.81 1.12 0.51]), depression 0.70 0.93 -0.46]). Moderate low significant observed gastrointestinal motility (0.83 [0.45-1.10]), life 1.02 1.66 0.37]), anxiety 0.72 1.10 0.35]), serum inflammatory markers 5.98 9.20 2.75]), diabetes risk 3.46 4.72 2.20]). However, there no improvements Bristol Stool scores, constipation, antioxidant capacity, dyslipidemia. In subgroup analysis, capsules improved compared fermented milk.Probiotic supplements may suitable for improving symptoms reducing depression. Further research warranted determine mechanism action optimal protocol.
Язык: Английский
Процитировано
25
Nutrients, Год журнала: 2023, Номер 15(21), С. 4663 - 4663
Опубликована: Ноя. 3, 2023
The role of probiotic supplementation in type 2 diabetes (T2D) treatment is controversial. present study aimed to assess the effects a multi-strain supplement (LactoLevureR (containing Lactobacillus acidophilus, plantarum, Bifidobacterium lactis, and Saccharomyces boulardii)) over 6 months, primarily on glycemic control as well lipid levels alterations gut microbiome, among individuals with T2D residing Greece. A total 91 adults (mean age [±SD] 65.12 ± 10.92 years, 62.6% males) were randomized receive or matching placebo capsule, once daily, for months. Blood chemistries anthropometric parameters conducted every 3 stool samples collected at baseline Significant reductions HbA1c, fasting blood glucose, cholesterol observed participants treated (n = 46) compared controls 45), even after adjustment greater decrease adiposity (waist circumference). Although there no statistically significant differences diversity microbiome (α β diversity), administration probiotics did influence several genera, metabolites, key enzymes associated diabetes. Overall, LactoLevureR 6-month period was well-tolerated had positive impact metabolic parameters, alongside improvements indices adiposity.
Язык: Английский
Процитировано
25
BMC Gastroenterology, Год журнала: 2024, Номер 24(1)
Опубликована: Авг. 22, 2024
There is a contradiction in the use of microbiota-therapies, including probiotics, prebiotics, and synbiotics, to improve condition patients with nonalcoholic fatty liver disease (NAFLD). The aim this review was evaluate effect microbiota-therapy on injury, inflammation, lipid levels individuals NAFLD. Using Pubmed, Embase, Cochrane Library, Web Science databases were searched for articles prebiotic, probiotic, or synbiotic treatment NAFLD up March 2024. Thirty-four studies involving 12,682 included. Meta-analysis indicated that supplementation significantly improved injury (hepatic fibrosis, SMD = -0.31; 95% CI: -0.53, -0.09; aspartate aminotransferase, -0.35; -0.55, -0.15; alanine -0.48; -0.71, -0.25; alkaline phosphatase, -0.81; -1.55, -0.08), profiles (triglycerides, -0.22; -0.43, -0.02), inflammatory factors (high-density lipoprotein, -0.47; -0.88, -0.06; tumour necrosis factor alpha, -0.86 -1.56, -0.56). Overall, had positive reducing enzymes, profiles, cytokines
Язык: Английский
Процитировано
17
Pharmacological Research, Год журнала: 2024, Номер 208, С. 107398 - 107398
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
11
AJP Endocrinology and Metabolism, Год журнала: 2024, Номер 327(1), С. E89 - E102
Опубликована: Май 29, 2024
The gut microbiome, a complex assembly of microorganisms, significantly impacts human health by influencing nutrient absorption, the immune system, and disease response. These microorganisms form dynamic ecosystem that is critical to maintaining overall well-being. Prebiotics probiotics are pivotal in regulating microbiota composition. nourish beneficial bacteria promote their growth, whereas help maintain balance within microbiome. This intricate extends several aspects health, including integrity barrier, responses, producing metabolites crucial for metabolic health. Dysbiosis, or an imbalance microbiota, has been linked disorders such as type 2 diabetes, obesity, cardiovascular disease. Impaired barrier function, endotoxemia, low-grade inflammation associated with toll-like receptors proinflammatory pathways. Short-chain fatty acids derived from microbial fermentation modulate anti-inflammatory system positively influence probiotics, especially Lactobacillus Bifidobacterium strains, may improve outcomes, glycemic control diabetes. It important consider strain-specific effects study variability when interpreting these findings, highlighting need further research optimize therapeutic potential. aim this report therefore review role prebiotics on microbiome role, integrating broad understanding physiological mechanisms clinical perspective.
Язык: Английский
Процитировано
10
Clinical Nutrition, Год журнала: 2024, Номер 43(4), С. 1041 - 1061
Опубликована: Март 20, 2024
SummaryBackground & aimsThe escalating prevalence of diabetes mellitus may benefit from add-on therapeutic approaches. Given the recognized need for an updated synthesis literature, this systematic review and meta-analysis aimed to synthesize critically assess available randomized controlled trials (RCTs) that investigate efficacy probiotics synbiotics on glycemic control in patients with Type 1 (T1DM) 2 (T2DM) mellitus.MethodsComprehensive searches were conducted PubMed, Embase, CINAHL, Scopus, Web Science, focusing adults T1DM or T2DM. All comparators deemed eligible. Primary outcomes included changes glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), insulin levels. Only RCTs included, Cochrane RoB2 tool assessed risk bias. Random-effect models facilitated data analysis, supplemented by sensitivity, subgroup analyses, meta-regressions.ResultsA total 537 records screened, resulting 41 which comprises 2991 (54% females) diabetes. The revealed statistically significant improvements HbA1c (standardized mean difference (SMD) = −0.282, 95% CI: [-0.37, −0.19], p < 0.001), FPG (SMD −0.175, [-0.26, −0.09], levels −0.273, [-0.35, −0.20], 0.001). A medium degree heterogeneity between studies was found (I2 62.5%), 71.5%), 66.4%) analyses. Subgroup analyses indicated varied based type strains used country. Multispecies particularly effective improving levels.ConclusionThe study findings suggest be as complementary therapies managing Additionally, underscores further tailored research considers variables such strain types geographical factors deepen understanding role these interventions care.Review registration numberPROSPERO (CRD42023396348).
Язык: Английский
Процитировано
9
Advances in Nutrition, Год журнала: 2024, Номер 15(8), С. 100265 - 100265
Опубликована: Июль 6, 2024
Probiotics are typically marketed as foods and dietary supplements, categories for products intended to maintain health in generally healthy populations which, unlike drugs, cannot claim treat or cure disease. This review addresses the existing evidence that probiotics beneficial people. Our approach was perform a descriptive of efficacy can prevent urinary, vaginal, gastrointestinal, respiratory infections, improve risk factors associated with cardiovascular reduce antibiotic use. Other endpoints such mental, dental, immune were not specifically addressed. We concluded there is sufficient safety clinicians consumers consider using specific some indications - use support gut function during tract infections certain However, we did find sufficiently high level unconditional, population-wide recommendations other preventive reviewed Although suggestive benefits probiotics, additional research needed.
Язык: Английский
Процитировано
8
Inflammopharmacology, Год журнала: 2023, Номер 31(5), С. 2253 - 2268
Опубликована: Сен. 12, 2023
Язык: Английский
Процитировано
17
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Июль 24, 2024
Type 2 diabetes mellitus(T2DM) is characterized by hyperglycemia. Gut microbiome adjustment plays a positive part in glucose regulation, which has become hotspot. Probiotics have been studied for their potential to control the gut flora and treat T2DM. However, conclusion of its glucose-lowering effect inconsistent based on different probiotic intervention times.
Язык: Английский
Процитировано
4
Diabetology & Metabolic Syndrome, Год журнала: 2024, Номер 16(1)
Опубликована: Янв. 22, 2024
Abstract Background Abnormalities in glucose and lipid metabolism contribute to the progression exacerbation of type 2 diabetes mellitus (T2DM). Fish oil probiotics are dietary supplements that have potential improve metabolism. However, their efficacy remains unclear T2DM patients. Methods PubMed, Embase, Cochrane Library were retrieved collect randomized controlled trials (RCTs) on fish or probiotic supplementation patients from database inception December 13, 2023. Primary outcome indicators encompassed glycated hemoglobin (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR) blood profile (triglyceride (TG) total cholesterol (TC). Secondary included inflammatory markers such as tumor necrosis factor -α (TNF-α) adipocytokine (including leptin adiponectin). The R software was used statistical analysis, GraphPad Prism figure rendering. Results A 60 RCTs involving 3845 analysis. results showed ( Bifidobacterium, Lactobacillus, Lactococcus, Propionibacterium, etc . ) more effective reducing HOMA-IR than (Surca = 0.935). Bifidobacterium demonstrated highest HbA1c levels 0.963). Regarding metabolism, superior lowering TG TC values 0.978 0.902, respectively). Furthermore, outperformed TNF-α 0.839) 0.712), increasing adiponectin 0.742). Node-splitting analysis good consistency (P > 0.05 direct, indirect, network comparison across various interventions). Conclusions In patients, regulating Probiotics particularly; specifically, higher glucose.
Язык: Английский
Процитировано
3