Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 27, 2022
Observations
of
women
and
clinicians
indicated
that
the
prevalence
menstrual
cycle
problems
has
escalated
during
COVID-19
pandemic.
However,
it
was
not
clear
whether
observed
changes
were
related
to
vaccination,
disease
itself
or
pandemic-induced
psychological
alterations.
To
systematically
analyze
this
question,
we
conducted
a
human
online
survey
in
aged
between
18
65
Hungary.
The
1563
individuals
analyzed
our
study
relation
infection,
pandemic
mental
health.
We
found
no
association
vaccine
types
infection
changes.
also
evaluated
alterations
focusing
on
three
parameters
including
length,
menses
length
regularity
phases:
pre-peak,
peak
post-peak
period
Our
finding
did
change
any
periods.
increased,
while
decreased
significantly
when
comparing
pre-
In
addition,
exhibited
both
correlated
with
severity
depression
period,
therefore
concluded
reported
abnormalities
Hungary
might
be
result
elevated
depressive
symptoms.
Frontiers in Drug Safety and Regulation,
Год журнала:
2024,
Номер
4
Опубликована: Янв. 31, 2024
Introduction:
Menstrual
disorders
are
commonly
reported
after
COVID-19
vaccination
and
heavy
menstrual
bleeding
was
added
to
the
product
information
of
vaccines
Moderna
Pfizer.
The
aim
this
review,
using
a
systematic
search,
is
provide
an
overview
available
literature
on
risk
vaccination.
Methods:
review
conducted
according
Preferred
Reporting
Items
for
Systematic
reviews
Meta-Analysis
(PRISMA)
guidelines.
A
PubMed
search
performed
15
August
2023,
including
solely
quantitative
studies
in
English
Dutch.
Results:
total
61
were
included,
which
40
cross-sectional
studies,
18
cohort
three
self-controlled
case
series.
Outcomes
included
wide
variety
disorders,
changes
cycle
length
(
n
=
54),
amount
44),
menses
30),
experience
(pre)menstrual
pain
21),
breakthrough
18).
All
found
higher
percentage
at
least
one
disorder
first
different
types
doses.
Discussion:
In
conclusion,
evidence
suggests
that
may
cause
women
reproductive
age.
However,
there
need
more
longitudinal
because
important
limitations
study
designs
many
studies.
Although
short-lived
predominantly
mild,
it
healthcare
professionals
be
informed
about
these
potential
adverse
reactions
assess
events
clinical
trials
vaccines.
Balkan Medical Journal,
Год журнала:
2023,
Номер
40(3), С. 153 - 164
Опубликована: Апрель 28, 2023
Several
studies
and
research
papers
have
been
published
to
elucidate
understand
the
mechanism
of
coronavirus
disease
2019
(COVID-19)
pandemic
its
long-term
effects
on
human
body.
COVID-19
affects
a
number
organs,
including
female
reproductive
system.
However,
less
attention
has
given
system
due
their
low
morbidity.
The
results
investigating
relationship
between
infection
ovarian
function
in
women
age
shown
harmless
involvement
infection.
reported
oocyte
quality,
function,
dysfunctions
uterine
endometrium
menstrual
cycle.
findings
these
indicate
that
negatively
follicular
microenvironment
dysregulate
function.
Although
health
studied
humans
animals,
very
few
examined
how
objective
this
review
is
summarize
current
literature
categorize
system,
ovaries,
uterus,
hormonal
profiles.
maturation,
oxidative
stress,
which
causes
chromosomal
instability
apoptosis
vitro
fertilization
cycle,
high-quality
embryos,
premature
insufficiency,
vein
thrombosis,
hypercoagulable
state,
women’s
hypothalamus-pituitary-ovary
axis,
sex
hormones,
estrogen,
progesterone,
anti-Müllerian
hormone,
are
discussed
particular.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 10, 2022
Purpose
The
purpose
of
this
study
was
to
describe
the
current
knowledge
on
potential
endocrine
adverse
effects
post-COVID-19
vaccines.
Methods
A
PubMed/MEDLINE,
Web
Science,
and
Scopus
research
performed.
Case
reports,
case
series,
original
studies,
reviews
written
in
English
published
online
up
31
July
2022
were
selected
reviewed.
final
reference
list
defined
based
relevance
each
paper
scope
review.
Results
available
data
showed
that
side
are
generally
rare
with
favorable
outcome,
being
thyroid
disorders
most
common.
Conversely,
type
1
diabetes
mellitus
rare;
adrenal
pituitary
events
even
anecdotal.
Finally,
clinical
studies
suggest
no
impact
female
reproductive
system
male
couple
fertility.
Conclusion
Overall,
these
show
that,
after
2
years
COVID-19
vaccines,
is
not
heavily
threatened.
Journal of Women s Health,
Год журнала:
2022,
Номер
31(8), С. 1097 - 1102
Опубликована: Июнь 20, 2022
Background:
Some
studies
have
suggested
minor
changes
in
the
menstrual
cycle
after
COVID-19
vaccination,
but
more
detailed
analyses
of
are
needed
to
evaluate
specific
that
not
affected
by
survey-based
recall
bias.
Materials
and
Methods:
Using
a
pretest-post-test
quasi-experimental
evaluation
parameters
before
we
conducted
an
anonymous
online
survey
two
groups
North
American
women
who
prospectively
monitor
their
daily
including
bleeding
patterns,
urinary
hormone
levels
using
ClearBlue
Fertility
Monitor,
or
cervical
mucus
observations.
The
primary
outcome
measures
were
length,
length
menses,
volume,
estimated
day
ovulation
(EDO),
luteal
phase
signs
ovulation.
Perceived
(subjective)
stressors
also
evaluated
this
study
as
secondary
measures.
Results:
Of
279
initiated
survey,
76
met
inclusion
criteria
provided
588
cycles
for
analysis
(227
pre-vaccine
cycles,
145
vaccine
216
post-vaccine
cycles).
Although
22%
subjectively
identified
cycle,
there
no
significant
differences
(cycle
EOD,
length)
between
pre-vaccine,
vaccine,
cycles.
Conclusions:
vaccines
associated
with
parameters.
individual
woman
must
be
compared
statistical
avoid
confirmation
British Journal of Clinical Pharmacology,
Год журнала:
2023,
Номер
89(10), С. 3126 - 3138
Опубликована: Май 24, 2023
During
the
COVID-19
vaccination
campaigns,
number
of
reports
menstrual
abnormalities
increased
rapidly.
Here,
we
describe
nature
and
potential
risk
factors
associated
with
based
on
spontaneously
reporting
data
as
well
from
a
prospective
cohort
event
monitoring
(CEM)
study
these
are
poorly
studied.Reports
received
by
Netherlands
Pharmacovigilance
Centre
Lareb
in
spontaneous
system
between
February
2021
April
2022
were
summarized.
In
addition,
logistic
regression
analysis
was
performed
reported
CEM
to
assess
association
person
characteristics,
prior
SARS-CoV-2
infection
use
hormonal
contraceptives
occurrence
after
vaccination.We
analysed
over
24
000
500
episodes
(among
16
929
included
women)
study.
The
showed
an
incidence
41.4
per
1000
women
aged
≤54
years.
Amenorrhoea/oligomenorrhoea
heavy
bleeding
collectively
accounted
for
about
half
all
reported.
Significant
associations
observed
age
group
25-34
years
(odds
ratio
2.18;
95%
confidence
interval
1.45-3.41)
Pfizer
vaccine
3.04;
2.36-3.93).
No
body
mass
index
presence
most
comorbidities
assessed.The
high
disorders
among
years,
this
observation
supported
reports.
This
suggests
that
relation
is
plausible
should
be
further
investigated.
Obstetrics and Gynecology,
Год журнала:
2023,
Номер
143(1), С. 83 - 91
Опубликована: Авг. 10, 2023
To
assess
whether
coronavirus
disease
2019
(COVID-19)
is
associated
with
menstrual
cycle
length
changes
and,
if
so,
how
that
compares
those
undergoing
vaccination
or
no
event
(control).We
conducted
a
retrospective
cohort
analysis
in
which
we
analyzed
prospectively
tracked
cycle-length
data
from
users
of
period
tracker
application
who
also
responded
to
survey
regarding
COVID-19
symptoms
and
vaccination.
We
restricted
our
sample
aged
16-45
years,
normal
lengths
(24-38
days)
regular
tracking
behavior
during
the
five
cycles
around
similar
time
for
experiencing
(control
group).
calculated
within-user
change
(days)
three
consecutive
preevent
average
(either
vaccination,
disease,
neither;
1-3)
(cycle
4)
postevent
5)
cycles.
used
mixed-effects
models
estimate
age-
country-adjusted
difference
across
groups.We
included
6,514
110
countries
representing
32,570
(COVID-19
symptoms:
1,450;
vaccination:
4,643;
control:
421).
The
experienced
1.45-day
adjusted
increase
4
compared
their
(95%
CI
0.86-2.04).
vaccinated
group
1.14-day
vaccine)
0.60-1.69).
control
(neither
vaccine
nor
disease)
0.68-day
decrease
-1.18
-0.19)
period.
Post
hoc
tests
showed
significant
differences
magnitude
between
cohorts.
In
both
cohorts,
disappeared
cycle.Experiencing
small
These
resolve
quickly
within
next
cycle.
Numerous
anecdotal
accounts
and
qualitative
research
studies
have
reported
on
post-vaccination
menstrual
irregularities
in
women
of
reproductive
age.
However,
none
quantified
the
impact.
This
is
first
systematic
review
meta-analysis
to
quantify
characterize
associated
with
vaccination
for
A
search
July
20,
2022,
retrieved
articles
published
between
December
1,
2019,
from
MEDLINE,
Embase,
Web
Science.
The
included
were
full
texts
written
English
that
vaccinated
vs.
unvaccinated
quality
was
evaluated
using
Study
Quality
Assessment
Tool
Observation
Cohort
Cross-Sectional
Studies.
Four
observational
included.
Review
Manager
used
generating
a
forest
plot
odds
ratios
(ORs)
at
95%
confidence
interval
(CI),
finding
statistically
significant
associations
25,054
age
(OR
=
1.91,
CI:
1.76–2.07)
overall
effect
mean
(
Z
16.01,
p
<
0.0001).
heterogeneous
dispersion
values
(χ
2
195.10
df
3,
0.00001,
I
98%).
findings
this
are
limited
by
availability
quantitative
data.
results
implications
treating
informing
them
about
potential
side
effects
vaccinations.
Healthcare,
Год журнала:
2023,
Номер
11(2), С. 186 - 186
Опубликована: Янв. 7, 2023
People
with
sub-threshold
autistic
traits
(SATs)
are
more
prone
to
develop
addictive
behaviors
such
the
ones
linked
Internet
abuse.
The
restrictions
for
anti-COVID-19
distancing
measures
encourage
social
isolation
and,
consequently,
increase
screen
time,
which
may
lead
addiction
(IA).
However,
a
better
quality
of
life
(QoL)
have
function
as
protective
factor
against
development
IA.
This
study
wanted
investigate
relation
between
SATs,
QoL,
and
overuse
in
group
141
university
students
North
Italy.
Participants
completed
battery
tests.
Results
suggest
that
QoL
is
predictive
IA
relationship
significantly
moderated
by
SATs.
could
mean
SATs
might
represent
risk
IA,
even
when
people
life.
Differences
female
male
discussed,
well
possible
implications
practice.