Menstrual disorders following COVID-19 vaccination: a review using a systematic search

Frontiers in Drug Safety and Regulation, Год журнала: 2024, Номер 4

Опубликована: Янв. 31, 2024

Introduction: Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of vaccines Moderna Pfizer. The aim this review, using a systematic search, is provide an overview available literature on risk vaccination. Methods: review conducted according Preferred Reporting Items for Systematic reviews Meta-Analysis (PRISMA) guidelines. A PubMed search performed 15 August 2023, including solely quantitative studies in English Dutch. Results: total 61 were included, which 40 cross-sectional studies, 18 cohort three self-controlled case series. Outcomes included wide variety disorders, changes cycle length ( n = 54), amount 44), menses 30), experience (pre)menstrual pain 21), breakthrough 18). All found higher percentage at least one disorder first different types doses. Discussion: In conclusion, evidence suggests that may cause women reproductive age. However, there need more longitudinal because important limitations study designs many studies. Although short-lived predominantly mild, it healthcare professionals be informed about these potential adverse reactions assess events clinical trials vaccines.

Язык: Английский

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Effects of COVID-19 Infection and Vaccination on the Female Reproductive System: A Narrative Review

Balkan Medical Journal, Год журнала: 2023, Номер 40(3), С. 153 - 164

Опубликована: Апрель 28, 2023

Several studies and research papers have been published to elucidate understand the mechanism of coronavirus disease 2019 (COVID-19) pandemic its long-term effects on human body. COVID-19 affects a number organs, including female reproductive system. However, less attention has given system due their low morbidity. The results investigating relationship between infection ovarian function in women age shown harmless involvement infection. reported oocyte quality, function, dysfunctions uterine endometrium menstrual cycle. findings these indicate that negatively follicular microenvironment dysregulate function. Although health studied humans animals, very few examined how objective this review is summarize current literature categorize system, ovaries, uterus, hormonal profiles. maturation, oxidative stress, which causes chromosomal instability apoptosis vitro fertilization cycle, high-quality embryos, premature insufficiency, vein thrombosis, hypercoagulable state, women’s hypothalamus-pituitary-ovary axis, sex hormones, estrogen, progesterone, anti-Müllerian hormone, are discussed particular.

Язык: Английский

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Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 10, 2022

Purpose The purpose of this study was to describe the current knowledge on potential endocrine adverse effects post-COVID-19 vaccines. Methods A PubMed/MEDLINE, Web Science, and Scopus research performed. Case reports, case series, original studies, reviews written in English published online up 31 July 2022 were selected reviewed. final reference list defined based relevance each paper scope review. Results available data showed that side are generally rare with favorable outcome, being thyroid disorders most common. Conversely, type 1 diabetes mellitus rare; adrenal pituitary events even anecdotal. Finally, clinical studies suggest no impact female reproductive system male couple fertility. Conclusion Overall, these show that, after 2 years COVID-19 vaccines, is not heavily threatened.

Язык: Английский

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Menstrual abnormalities post-COVID vaccination: a cross-sectional study on adult Lebanese women

Irish Journal of Medical Science (1971 -), Год журнала: 2022, Номер 192(3), С. 1163 - 1170

Опубликована: Июль 26, 2022

Язык: Английский

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Menstrual Cycle Parameters Are Not Significantly Different After COVID-19 Vaccination

Journal of Women s Health, Год журнала: 2022, Номер 31(8), С. 1097 - 1102

Опубликована: Июнь 20, 2022

Background: Some studies have suggested minor changes in the menstrual cycle after COVID-19 vaccination, but more detailed analyses of are needed to evaluate specific that not affected by survey-based recall bias. Materials and Methods: Using a pretest-post-test quasi-experimental evaluation parameters before we conducted an anonymous online survey two groups North American women who prospectively monitor their daily including bleeding patterns, urinary hormone levels using ClearBlue Fertility Monitor, or cervical mucus observations. The primary outcome measures were length, length menses, volume, estimated day ovulation (EDO), luteal phase signs ovulation. Perceived (subjective) stressors also evaluated this study as secondary measures. Results: Of 279 initiated survey, 76 met inclusion criteria provided 588 cycles for analysis (227 pre-vaccine cycles, 145 vaccine 216 post-vaccine cycles). Although 22% subjectively identified cycle, there no significant differences (cycle EOD, length) between pre-vaccine, vaccine, cycles. Conclusions: vaccines associated with parameters. individual woman must be compared statistical avoid confirmation

Язык: Английский

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Association between COVID-19 vaccines and the menstrual cycle in young Japanese women

Journal of Infection and Chemotherapy, Год журнала: 2023, Номер 29(5), С. 513 - 518

Опубликована: Янв. 7, 2023

Язык: Английский

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Menstrual abnormalities after COVID‐19 vaccination in the Netherlands: A description of spontaneous and longitudinal patient‐reported data

British Journal of Clinical Pharmacology, Год журнала: 2023, Номер 89(10), С. 3126 - 3138

Опубликована: Май 24, 2023

During the COVID-19 vaccination campaigns, number of reports menstrual abnormalities increased rapidly. Here, we describe nature and potential risk factors associated with based on spontaneously reporting data as well from a prospective cohort event monitoring (CEM) study these are poorly studied.Reports received by Netherlands Pharmacovigilance Centre Lareb in spontaneous system between February 2021 April 2022 were summarized. In addition, logistic regression analysis was performed reported CEM to assess association person characteristics, prior SARS-CoV-2 infection use hormonal contraceptives occurrence after vaccination.We analysed over 24 000 500 episodes (among 16 929 included women) study. The showed an incidence 41.4 per 1000 women aged ≤54 years. Amenorrhoea/oligomenorrhoea heavy bleeding collectively accounted for about half all reported. Significant associations observed age group 25-34 years (odds ratio 2.18; 95% confidence interval 1.45-3.41) Pfizer vaccine 3.04; 2.36-3.93). No body mass index presence most comorbidities assessed.The high disorders among years, this observation supported reports. This suggests that relation is plausible should be further investigated.

Язык: Английский

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Associations Among Menstrual Cycle Length, Coronavirus Disease 2019 (COVID-19), and Vaccination

Obstetrics and Gynecology, Год журнала: 2023, Номер 143(1), С. 83 - 91

Опубликована: Авг. 10, 2023

To assess whether coronavirus disease 2019 (COVID-19) is associated with menstrual cycle length changes and, if so, how that compares those undergoing vaccination or no event (control).We conducted a retrospective cohort analysis in which we analyzed prospectively tracked cycle-length data from users of period tracker application who also responded to survey regarding COVID-19 symptoms and vaccination. We restricted our sample aged 16-45 years, normal lengths (24-38 days) regular tracking behavior during the five cycles around similar time for experiencing (control group). calculated within-user change (days) three consecutive preevent average (either vaccination, disease, neither; 1-3) (cycle 4) postevent 5) cycles. used mixed-effects models estimate age- country-adjusted difference across groups.We included 6,514 110 countries representing 32,570 (COVID-19 symptoms: 1,450; vaccination: 4,643; control: 421). The experienced 1.45-day adjusted increase 4 compared their (95% CI 0.86-2.04). vaccinated group 1.14-day vaccine) 0.60-1.69). control (neither vaccine nor disease) 0.68-day decrease -1.18 -0.19) period. Post hoc tests showed significant differences magnitude between cohorts. In both cohorts, disappeared cycle.Experiencing small These resolve quickly within next cycle.

Язык: Английский

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Effect of COVID-19 vaccination on the menstrual cycle

Frontiers in Medicine, Год журнала: 2022, Номер 9

Опубликована: Дек. 16, 2022

Numerous anecdotal accounts and qualitative research studies have reported on post-vaccination menstrual irregularities in women of reproductive age. However, none quantified the impact. This is first systematic review meta-analysis to quantify characterize associated with vaccination for A search July 20, 2022, retrieved articles published between December 1, 2019, from MEDLINE, Embase, Web Science. The included were full texts written English that vaccinated vs. unvaccinated quality was evaluated using Study Quality Assessment Tool Observation Cohort Cross-Sectional Studies. Four observational included. Review Manager used generating a forest plot odds ratios (ORs) at 95% confidence interval (CI), finding statistically significant associations 25,054 age (OR = 1.91, CI: 1.76–2.07) overall effect mean ( Z 16.01, p < 0.0001). heterogeneous dispersion values (χ 2 195.10 df 3, 0.00001, I 98%). findings this are limited by availability quantitative data. results implications treating informing them about potential side effects vaccinations.

Язык: Английский

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The Moderator Effect of Subthreshold Autistic Traits on the Relationship between Quality of Life and Internet Addiction

Healthcare, Год журнала: 2023, Номер 11(2), С. 186 - 186

Опубликована: Янв. 7, 2023

People with sub-threshold autistic traits (SATs) are more prone to develop addictive behaviors such the ones linked Internet abuse. The restrictions for anti-COVID-19 distancing measures encourage social isolation and, consequently, increase screen time, which may lead addiction (IA). However, a better quality of life (QoL) have function as protective factor against development IA. This study wanted investigate relation between SATs, QoL, and overuse in group 141 university students North Italy. Participants completed battery tests. Results suggest that QoL is predictive IA relationship significantly moderated by SATs. could mean SATs might represent risk IA, even when people life. Differences female male discussed, well possible implications practice.

Язык: Английский

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