Sinomenine Alleviates Experimental Autoimmune Uveitis in Rats: Possible Involvement of PI3K/AKT and NF-κB Signaling Pathways
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177571 - 177571
Опубликована: Апрель 1, 2025
Язык: Английский
Magnetically attracting hydrogel reshapes iron metabolism for tissue repair
Science Advances,
Год журнала:
2024,
Номер
10(33)
Опубликована: Авг. 16, 2024
Ferroptosis,
caused
by
disorders
of
iron
metabolism,
plays
a
critical
role
in
various
diseases,
making
the
regulation
metabolism
essential
for
tissue
repair.
In
our
analysis
degenerated
intervertebral
disc
tissue,
we
observe
positive
correlation
between
concentration
extracellular
ions
(ex-iron)
and
severity
ferroptosis
degeneration
(IVDD).
Hence,
inspired
magnets
attracting
metals,
combine
polyether
F127
diacrylate
(FDA)
with
tannin
(TA)
to
construct
magnetically
hydrogel
(FDA-TA).
This
demonstrates
capability
adsorb
ex-iron
remodel
cells.
Furthermore,
it
exhibits
good
toughness
self-healing
properties.
Notably,
can
activate
PI3K-AKT
pathway
inhibit
nuclear
receptor
coactivator
4–mediated
ferritinophagy
under
enrichment
conditions.
The
curative
effect
related
mechanism
are
further
confirmed
vivo.
Consequently,
on
basis
pathological
mechanism,
targeted
is
designed
reshape
offering
insights
Язык: Английский
The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration
Zhaobai Lao,
X. Fang,
Shuchao Shen
и другие.
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 7705 - 7719
Опубликована: Окт. 1, 2024
Systemic
lupus
erythematosus
(SLE)
is
an
autoimmune
disorder
marked
by
immune
system
dysregulation
and
autoantibodies
production,
causing
widespread
inflammation
damage
across
various
body
systems.
Despite
the
prevalent
back
pain
in
SLE
patients,
link
between
intervertebral
disc
(IVD)
degeneration,
a
primary
contributor
to
pain,
remains
inadequately
understood.
This
study
explored
impact
of
on
IVD
degeneration
using
MRL/
Язык: Английский
A Multifunctional Photothermal Electrospun PLGA/MoS2@Pd Nanofiber Membrane for Diabetic Wound Healing
Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 14, 2024
Abstract
Injury
caused
by
excess
reactive
oxygen
species
(ROS)
may
lead
to
susceptibility
bacterial
infection
and
sustained
inflammatory
response,
which
are
the
major
factors
impeding
diabetic
wound
healing.
By
utilizing
optimal
anti-inflammatory,
antioxidant
antibacterial
biomaterials
for
multifunctional
dressings
is
critical
in
clinical
applications.
In
this
study,
a
novel
electrospun
PLGA/MoS2@Pd
nanofiber
membrane
was
synthesized
encapsulating
near-infrared
(NIR)
responsive
MOS2@Pd
nanozymes
PLGA
nanofibers
form
dressing
repair.
With
excellent
biocompatibility
hemostatic
ability,
can
effectively
reduce
oxidative
stress
damage
intracellular
expression
fibroblasts
scavenging
ROS.
Additionally,
exhibited
favorable
NIR-mediated
photothermal
activity
vitro,
with
inhibition
rates
of
97.14%
97.07%
against
Staphylococcus
aureus
(S.aureus)
Escherichia
coli
(E.coli),
respectively.
rat
model,
NIR-assisted
inhibited
growth
wound,
reduced
infection-induced
promoted
tissue
epithelialization
collagen
deposition,
resulting
healing
rate
up
98.5%
on
Day
14.
This
study
highlighted
construction
platform
demonstrated
its
promising
potential
as
wounds.
Язык: Английский