A Multifunctional Photothermal Electrospun PLGA/MoS2@Pd Nanofiber Membrane for Diabetic Wound Healing DOI Creative Commons
Zhengrong Chen, Q. Mo,

Dandan Mo

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 14, 2024

Abstract Injury caused by excess reactive oxygen species (ROS) may lead to susceptibility bacterial infection and sustained inflammatory response, which are the major factors impeding diabetic wound healing. By utilizing optimal anti-inflammatory, antioxidant antibacterial biomaterials for multifunctional dressings is critical in clinical applications. In this study, a novel electrospun PLGA/MoS2@Pd nanofiber membrane was synthesized encapsulating near-infrared (NIR) responsive MOS2@Pd nanozymes PLGA nanofibers form dressing repair. With excellent biocompatibility hemostatic ability, can effectively reduce oxidative stress damage intracellular expression fibroblasts scavenging ROS. Additionally, exhibited favorable NIR-mediated photothermal activity vitro, with inhibition rates of 97.14% 97.07% against Staphylococcus aureus (S.aureus) Escherichia coli (E.coli), respectively. rat model, NIR-assisted inhibited growth wound, reduced infection-induced promoted tissue epithelialization collagen deposition, resulting healing rate up 98.5% on Day 14. This study highlighted construction platform demonstrated its promising potential as wounds.

Language: Английский

Sinomenine Alleviates Experimental Autoimmune Uveitis in Rats: Possible Involvement of PI3K/AKT and NF-κB Signaling Pathways DOI
Qing Gao, Jun Peng, Meng Xiong

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177571 - 177571

Published: April 1, 2025

Language: Английский

Citations

0
Magnetically attracting hydrogel reshapes iron metabolism for tissue repair DOI Creative Commons
Yichang Xu, Feng Cai,

Yidi Zhou

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(33)

Published: Aug. 16, 2024

Ferroptosis, caused by disorders of iron metabolism, plays a critical role in various diseases, making the regulation metabolism essential for tissue repair. In our analysis degenerated intervertebral disc tissue, we observe positive correlation between concentration extracellular ions (ex-iron) and severity ferroptosis degeneration (IVDD). Hence, inspired magnets attracting metals, combine polyether F127 diacrylate (FDA) with tannin (TA) to construct magnetically hydrogel (FDA-TA). This demonstrates capability adsorb ex-iron remodel cells. Furthermore, it exhibits good toughness self-healing properties. Notably, can activate PI3K-AKT pathway inhibit nuclear receptor coactivator 4–mediated ferritinophagy under enrichment conditions. The curative effect related mechanism are further confirmed vivo. Consequently, on basis pathological mechanism, targeted is designed reshape offering insights

Language: Английский

Citations

2
The Onset of Systemic Lupus Erythematosus Triggers Nucleus Pulposus Cell Pyroptosis to Exacerbate Intervertebral Disc Degeneration DOI Creative Commons

Zhaobai Lao,

X. Fang,

Shuchao Shen

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7705 - 7719

Published: Oct. 1, 2024

Systemic lupus erythematosus (SLE) is an autoimmune disorder marked by immune system dysregulation and autoantibodies production, causing widespread inflammation damage across various body systems. Despite the prevalent back pain in SLE patients, link between intervertebral disc (IVD) degeneration, a primary contributor to pain, remains inadequately understood. This study explored impact of on IVD degeneration using MRL/

Language: Английский

Citations

2
A Multifunctional Photothermal Electrospun PLGA/MoS2@Pd Nanofiber Membrane for Diabetic Wound Healing DOI Creative Commons
Zhengrong Chen, Q. Mo,

Dandan Mo

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 14, 2024

Abstract Injury caused by excess reactive oxygen species (ROS) may lead to susceptibility bacterial infection and sustained inflammatory response, which are the major factors impeding diabetic wound healing. By utilizing optimal anti-inflammatory, antioxidant antibacterial biomaterials for multifunctional dressings is critical in clinical applications. In this study, a novel electrospun PLGA/MoS2@Pd nanofiber membrane was synthesized encapsulating near-infrared (NIR) responsive MOS2@Pd nanozymes PLGA nanofibers form dressing repair. With excellent biocompatibility hemostatic ability, can effectively reduce oxidative stress damage intracellular expression fibroblasts scavenging ROS. Additionally, exhibited favorable NIR-mediated photothermal activity vitro, with inhibition rates of 97.14% 97.07% against Staphylococcus aureus (S.aureus) Escherichia coli (E.coli), respectively. rat model, NIR-assisted inhibited growth wound, reduced infection-induced promoted tissue epithelialization collagen deposition, resulting healing rate up 98.5% on Day 14. This study highlighted construction platform demonstrated its promising potential as wounds.

Language: Английский

Citations

0