Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis DOI Creative Commons
Zhixiang Zhang, Zhiqiang Shao,

Zonghan Xu

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 20, 2024

Osteoarthritis (OA) and rheumatoid arthritis (RA) are often difficult to distinguish in the early stage of disease. The purpose this study was explore similarities differences between two diseases through Mendelian randomization (MR) transcriptome analysis.

Язык: Английский

FCGR1A(CD64) Expression on Monocyte Subsets and FIL1Z(IL-37) Serum Level as Biomarkers of Rheumatoid Arthritis Activity; A Case Controlled Study and In Silico Analysis DOI
Entsar R. Mokhtar, Doaa Aly Abd El-Fattah,

Neama Rmadan Hussein

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер 269, С. 155910 - 155910

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis DOI
Lei Zhang,

Guoquan Wu,

Junwei Yao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 143143 - 143143

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Post-marketing safety of anakinra and canakinumab: a real-world pharmacovigilance study based on FDA adverse event reporting system DOI Creative Commons
Hao Liu, Wei Yan, Jinsong Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 30, 2025

Anakinra and canakinumab are two FDA-approved IL-1 blockers indicated for the treatment of multiple autoinflammatory diseases, yet their safety has not been comprehensively analyzed. We aimed to assess signals associated with anakinra by conducting a pharmacovigilance analysis using FDA Adverse Event Reporting System (FAERS) database. reaction data spanning from first quarter 2004 fourth 2023 was downloaded FAERS A disproportionality utilizing various methods, including reporting odds ratio (ROR), proportional (PRR), Bayesian confidence propagation neural network (BCPNN), Empirical Bayes Geometric Mean (EBGM), conducted. were identified as primary suspect drugs adverse events (AEs) in 7,544 8,044 reports, respectively. The most commonly reported SOCs both general disorders administration site conditions. Subgroup analyses that SOC among health professionals non-health remained consistent across medications. At preferred term (PT) level, drug labeling, common AEs included injection reactions (ISRs) infections. Further revealed higher frequency ISRs anakinra, pain erythema. In contrast, more gastrointestinal (abdominal pain, mouth ulceration, inflammatory bowel disease) respiratory (cough, oropharyngeal rhinorrhea); these conditions predominantly occurred minors. Notably, no significant related tuberculosis infection or reactivation observed, hepatic injury malignancy low. This study confirms favorable profiles canakinumab, offering critical insights into rational usage regulations.

Язык: Английский

Процитировано

0
IL‐37 Mitigates the Inflammatory Response in Macrophages Induced by SARS‐CoV‐2 Omicron Infection Through the NF‐κB Signaling Pathway DOI Creative Commons
Feifei Qi, Yiwei Yan,

Mingya Liu

и другие.

MedComm, Год журнала: 2025, Номер 6(6)

Опубликована: Май 31, 2025

ABSTRACT The expression levels of macrophage‐associated cytokines are significantly greater in COVID‐19 patients than healthy individuals. Exploring strategies to modulate pathological cytokine storms can effectively prevent the development severe coronavirus infection‐induced pneumonia. Treatment with interleukin‐37 (IL‐37), an anti‐inflammatory factor, has unique and antiviral effects on infections caused by various pathogens. In this study, we investigated effect IL‐37 treatment SARS‐CoV‐2 Omicron‐infection induced inflammatory response its molecular mechanism. Our results demonstrated that alleviated symptoms, reduced viral loads, suppressed production proinflammatory chemokines both systemically (in serum) locally lungs), attenuated lung lesions cell infiltration Omicron‐infected mice. factors were macrophage‐related, particularly CCL3 CCL4, which inhibited. Furthermore, proportion M1‐type macrophages lungs addition, found targeted M1 through modulation NF‐κB signaling pathway suppress proinflammtory during Omicron infection. This study elucidated Omicron‐induced while identifying specific target site, thereby providing fundamental insights for exploring potential clinical therapeutic interventions.

Язык: Английский

Процитировано

0
Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis DOI Creative Commons
Zhixiang Zhang, Zhiqiang Shao,

Zonghan Xu

и другие.

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 20, 2024

Osteoarthritis (OA) and rheumatoid arthritis (RA) are often difficult to distinguish in the early stage of disease. The purpose this study was explore similarities differences between two diseases through Mendelian randomization (MR) transcriptome analysis.

Язык: Английский

Процитировано

0