Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis DOI Creative Commons
Zhixiang Zhang, Zhiqiang Shao,

Zonghan Xu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 20, 2024

Osteoarthritis (OA) and rheumatoid arthritis (RA) are often difficult to distinguish in the early stage of disease. The purpose this study was explore similarities differences between two diseases through Mendelian randomization (MR) transcriptome analysis.

Language: Английский

FCGR1A(CD64) Expression on Monocyte Subsets and FIL1Z(IL-37) Serum Level as Biomarkers of Rheumatoid Arthritis Activity; A Case Controlled Study and In Silico Analysis DOI
Entsar R. Mokhtar, Doaa Aly Abd El-Fattah,

Neama Rmadan Hussein

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155910 - 155910

Published: March 12, 2025

Language: Английский

Citations

0
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis DOI
Lei Zhang,

Guoquan Wu,

Junwei Yao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 143143 - 143143

Published: April 14, 2025

Language: Английский

Citations

0
Post-marketing safety of anakinra and canakinumab: a real-world pharmacovigilance study based on FDA adverse event reporting system DOI Creative Commons
Hao Liu, Wei Yan, Jinsong Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Anakinra and canakinumab are two FDA-approved IL-1 blockers indicated for the treatment of multiple autoinflammatory diseases, yet their safety has not been comprehensively analyzed. We aimed to assess signals associated with anakinra by conducting a pharmacovigilance analysis using FDA Adverse Event Reporting System (FAERS) database. reaction data spanning from first quarter 2004 fourth 2023 was downloaded FAERS A disproportionality utilizing various methods, including reporting odds ratio (ROR), proportional (PRR), Bayesian confidence propagation neural network (BCPNN), Empirical Bayes Geometric Mean (EBGM), conducted. were identified as primary suspect drugs adverse events (AEs) in 7,544 8,044 reports, respectively. The most commonly reported SOCs both general disorders administration site conditions. Subgroup analyses that SOC among health professionals non-health remained consistent across medications. At preferred term (PT) level, drug labeling, common AEs included injection reactions (ISRs) infections. Further revealed higher frequency ISRs anakinra, pain erythema. In contrast, more gastrointestinal (abdominal pain, mouth ulceration, inflammatory bowel disease) respiratory (cough, oropharyngeal rhinorrhea); these conditions predominantly occurred minors. Notably, no significant related tuberculosis infection or reactivation observed, hepatic injury malignancy low. This study confirms favorable profiles canakinumab, offering critical insights into rational usage regulations.

Language: Английский

Citations

0
Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis DOI Creative Commons
Zhixiang Zhang, Zhiqiang Shao,

Zonghan Xu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 20, 2024

Osteoarthritis (OA) and rheumatoid arthritis (RA) are often difficult to distinguish in the early stage of disease. The purpose this study was explore similarities differences between two diseases through Mendelian randomization (MR) transcriptome analysis.

Language: Английский

Citations

0