Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

Translational Psychiatry, Год журнала: 2023, Номер 13(1)

Опубликована: Янв. 9, 2023

Abstract Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration. A variety neuromodulation techniques that regulate regional brain activities have been used to treat refractory mood disorders. However, their efficacy varies from person lack reliable indicator. This review summarizes clinical animal studies on inflammation in neural circuits related anxiety depression evidence therapies neuroinflammation treatment neurological diseases. Neuromodulation therapies, including transcranial magnetic stimulation (TMS), electrical (TES), electroconvulsive therapy (ECT), photobiomodulation (PBM), ultrasound (TUS), deep (DBS), vagus nerve (VNS), all reported attenuate reduce release pro-inflammatory factors, which may be one reasons for improvement. provides a better understanding effective mechanism indicates inflammatory biomarkers serve as reference assessment pathological conditions options depression.

Язык: Английский

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Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review

Life Sciences, Год журнала: 2022, Номер 307, С. 120869 - 120869

Опубликована: Авг. 6, 2022

Язык: Английский

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Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges

Inflammation and Regeneration, Год журнала: 2022, Номер 42(1)

Опубликована: Окт. 3, 2022

Abstract Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and most common form dementia. Characterized by loss learning, memory, problem-solving, language, other thinking abilities, AD exerts a detrimental effect on both patients’ families’ quality life. Although there have been significant advances in understanding mechanism underlying pathogenesis progression AD, no cure for AD. The failure numerous molecular targeted pharmacologic clinical trials leads to an emerging research shift toward non-invasive therapies, especially multiple treatments. In this paper, we reviewed widely studied including photobiomodulation (PBM), transcranial magnetic stimulation (TMS), direct current (tDCS), exercise therapy. Firstly, pathological changes challenges studies. We then introduced these therapies discussed factors that may affect effects therapies. Additionally, review possible mechanisms effects. Finally, summarized treatments future studies applications. concluded it would be critical understand exact find optimal treatment parameters improve translational value Moreover, combined use also promising direction sheds light or prevention

Язык: Английский

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Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation

Journal of Neuroscience Research, Год журнала: 2024, Номер 102(3)

Опубликована: Март 1, 2024

Abstract Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric that affects about 2%–3% of the global population. Despite availability several treatments, many patients with OCD do not respond adequately, highlighting need for new therapeutic approaches. Recent studies have associated various inflammatory processes pathogenesis OCD, including alterations in peripheral immune cells, cytokine levels, and neuroinflammation. These findings suggest inflammation could be promising target intervention. Transcranial photobiomodulation (t‐PBM) near‐infrared light noninvasive neuromodulation technique has shown potential disorders. However, its efficacy remains to fully explored. This study aimed review literature on detailing associations T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, IL‐6. We also examined hypothesis‐based t‐PBM targeting these pathways focusing mechanisms modulation oxidative stress, regulation cell function, reduction deactivation neurotoxic microglia, upregulation BDNF gene expression. Our suggests promising, intervention modulate underlying processes. Future research should focus randomized clinical trials assess t‐PBM's optimal treatment parameters OCD. Biomarker analyses neuroimaging will important understanding relationship between symptom improvement following sessions.

Язык: Английский

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Boosting psychological change: Combining non-invasive brain stimulation with psychotherapy

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 142, С. 104867 - 104867

Опубликована: Сен. 16, 2022

Язык: Английский

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Transcranial photobiomodulation in children aged 2–6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Апрель 26, 2024

Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological conditions, such as depression, traumatic brain injury, and autism spectrum disorder (ASD).

Язык: Английский

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Opportunities and obstacles in non-invasive brain stimulation

Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Март 18, 2024

Non-invasive brain stimulation (NIBS) is a complex and multifaceted approach to modulating activity holds the potential for broad accessibility. This work discusses mechanisms of four distinct approaches non-invasively: electrical currents, magnetic fields, light, ultrasound. We examine dual stochastic deterministic nature its implications NIBS, highlighting challenges posed by inter-individual variability, nebulous dose-response relationships, biases neuroanatomical heterogeneity. Looking forward, we propose five areas opportunity future research: closed-loop stimulation, consistent intended target region, reducing bias, multimodal approaches, strategies address low sample sizes.

Язык: Английский

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Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring

Theranostics, Год журнала: 2020, Номер 11(3), С. 1269 - 1294

Опубликована: Дек. 16, 2020

Neonatal hypoxic-ischemic (HI) injury is a severe complication often leading to neonatal death and long-term neurobehavioral deficits in children. Currently, the only treatment option available for HI therapeutic hypothermia. However, necessary specialized equipment, possible adverse side effects, limited effectiveness of this therapy creates an urgent need development new methods. Photobiomodulation (PBM) has been shown be neuroprotective against multiple brain disorders animal models, as well human studies. effects PBM on remain unclear. Methods: Two-minutes (808 nm continuous wave laser, 8 mW/cm2 brain) was applied three times weekly abdomen pregnant rats from gestation day 1 (GD1) GD21. After right common carotid artery ligation, cortex- hippocampus-related behavioral due insult were measured using battery tests. The pretreatment infarct size; synaptic, dendritic, white matter damage; neuronal degeneration; apoptosis; mitochondrial function; fragmentation; oxidative stress; gliosis then assessed. Results: Prenatal significantly improved survival rate decreased size after insult. Behavioral tests revealed that prenatal alleviated cortex-related motor memory learning dysfunction. In addition, function integrity protected animals treated with PBM. Additional studies HI-induced neuroinflammation, stress, myeloid cell/astrocyte activation. Conclusion: exerts rats. Underlying mechanisms neuroprotection may include preservation function, reduction inflammation, stress. Our findings support use high-risk pregnancies alleviate or prevent perinatal period.

Язык: Английский

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Defining Surgical Terminology and Risk for Brain Computer Interface Technologies

Frontiers in Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Март 26, 2021

With the emergence of numerous brain computer interfaces (BCI), their form factors, and clinical applications terminology to describe deployment associated risk has been vague. The terms “minimally invasive” or “non-invasive” have commonly used, but can vary widely based on factor anatomic location. Thus, taken together, there needs be a that best accommodates surgical footprint BCI attendant risks. This work presents semantic framework describes from procedural standpoint its profile. We propose extending common invasive/non-invasive distinction for systems accommodate three categories in which anatomically with patient whether not procedure is required deployment: (1) Non-invasive —BCI components do penetrate body, (2) Embedded —components are penetrative, deeper than inner table skull, (3) Intracranial –components located within skull possibly volume. Each class separate profile should considered when being applied given population. Optimally, balancing this need provides most ethical these emerging classes devices. As BCIs gain larger adoption, becomes standardized, having an improved, more precise language will better serve clinicians, patients, consumers discussing technologies, particularly context procedures.

Язык: Английский

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Photobiomodulation for Major Depressive Disorder: Linking Transcranial Infrared Light, Biophotons and Oxidative Stress

Harvard Review of Psychiatry, Год журнала: 2023, Номер 31(3), С. 124 - 141

Опубликована: Май 1, 2023

Abstract Incompletely treated major depressive disorder (MDD) poses an enormous global health burden. Conventional treatment for MDD consists of pharmacotherapy and psychotherapy, though a significant number patients do not achieve remission with such treatments. Transcranial photobiomodulation (t-PBM) is promising novel therapy that uses extracranial light, especially in the near-infrared (NIR) red spectra, biological therapeutic effects. The aims this Review are to evaluate current clinical preclinical literature on t-PBM discuss candidate mechanisms effects MDD, specific attention biophotons oxidative stress. A search PubMed ClinicalTrials.gov identified studies using as primary focus. After systematic screening, only 19 containing original data were included review (9 10 trials). Study results demonstrate consensus safe potentially effective treatment; however, varying parameters among complicate definitive conclusions about efficacy. Among other action, stimulates complex IV mitochondrial respiratory chain induces increase cellular energy metabolism. We suggest future trials include measures better understand action optimize efficiency. Of particular interest going forward will be studying potential t-PBM—an external light source NIR spectra—on neural circuitry implicated depression.

Язык: Английский

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