Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1 DOI Creative Commons

Radwa H. Lutfy,

Amina E. Essawy, Haitham S. Mohammed

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(4), P. 919 - 934

Published: Dec. 20, 2023

The growing prevalence of aged sleep-deprived nations is turning into a pandemic state. Acute sleep deprivation (SD) accompanies aging, changing the hippocampal cellular pattern, neurogenesis pathway expression, and aggravating cognitive deterioration. present study investigated ability Near Infra Red (NIR) light laser to ameliorate impairment induced by SD in young senile rats. Wistar rats ≤ 2 months (young) ≥ 14 (senile) were for 72 h with or without transcranial administration NIR 830 nm. Our results showed that photobiomodulation (PBM) attenuated deterioration made young, but not rats, while both exhibited decreased anxiety (mania)-like behavior response PBM. PBM had an inhibitory effect on AChE, enhanced production ACh, ROS, regulated cell apoptosis factors such as Bax Bcl-2. increased mRNA expression BDNF GLP-1 thus facilitating neuronal survival differentiation. findings also revealed age exerts additive factor assaults produced where damages 2-month less severe than those one. In conclusion, seems promote longevity cells combating elevating neurotrophic factors, improving performance. provide possible candidate insults accompanying aging SD.

Language: Английский

Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression DOI Creative Commons
Bingqi Guo,

Mengyao Zhang,

Wensi Hao

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 9, 2023

Abstract Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration. A variety neuromodulation techniques that regulate regional brain activities have been used to treat refractory mood disorders. However, their efficacy varies from person lack reliable indicator. This review summarizes clinical animal studies on inflammation in neural circuits related anxiety depression evidence therapies neuroinflammation treatment neurological diseases. Neuromodulation therapies, including transcranial magnetic stimulation (TMS), electrical (TES), electroconvulsive therapy (ECT), photobiomodulation (PBM), ultrasound (TUS), deep (DBS), vagus nerve (VNS), all reported attenuate reduce release pro-inflammatory factors, which may be one reasons for improvement. provides a better understanding effective mechanism indicates inflammatory biomarkers serve as reference assessment pathological conditions options depression.

Language: Английский

Citations

169
Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review DOI

Ethar Ahmed Mosilhy,

Eman E. Alshial, Mennatullah Mohamed Eltaras

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 307, P. 120869 - 120869

Published: Aug. 6, 2022

Language: Английский

Citations

56
Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges DOI Creative Commons

Chongyun Wu,

Luoman Yang,

Shu Feng

et al.

Inflammation and Regeneration, Journal Year: 2022, Volume and Issue: 42(1)

Published: Oct. 3, 2022

Abstract Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and most common form dementia. Characterized by loss learning, memory, problem-solving, language, other thinking abilities, AD exerts a detrimental effect on both patients’ families’ quality life. Although there have been significant advances in understanding mechanism underlying pathogenesis progression AD, no cure for AD. The failure numerous molecular targeted pharmacologic clinical trials leads to an emerging research shift toward non-invasive therapies, especially multiple treatments. In this paper, we reviewed widely studied including photobiomodulation (PBM), transcranial magnetic stimulation (TMS), direct current (tDCS), exercise therapy. Firstly, pathological changes challenges studies. We then introduced these therapies discussed factors that may affect effects therapies. Additionally, review possible mechanisms effects. Finally, summarized treatments future studies applications. concluded it would be critical understand exact find optimal treatment parameters improve translational value Moreover, combined use also promising direction sheds light or prevention

Language: Английский

Citations

48
Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation DOI
David Richer Araujo Coelho, Joshua D. Salvi, Willians Fernando Vieira

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(3)

Published: March 1, 2024

Abstract Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric that affects about 2%–3% of the global population. Despite availability several treatments, many patients with OCD do not respond adequately, highlighting need for new therapeutic approaches. Recent studies have associated various inflammatory processes pathogenesis OCD, including alterations in peripheral immune cells, cytokine levels, and neuroinflammation. These findings suggest inflammation could be promising target intervention. Transcranial photobiomodulation (t‐PBM) near‐infrared light noninvasive neuromodulation technique has shown potential disorders. However, its efficacy remains to fully explored. This study aimed review literature on detailing associations T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, IL‐6. We also examined hypothesis‐based t‐PBM targeting these pathways focusing mechanisms modulation oxidative stress, regulation cell function, reduction deactivation neurotoxic microglia, upregulation BDNF gene expression. Our suggests promising, intervention modulate underlying processes. Future research should focus randomized clinical trials assess t‐PBM's optimal treatment parameters OCD. Biomarker analyses neuroimaging will important understanding relationship between symptom improvement following sessions.

Language: Английский

Citations

12
Boosting psychological change: Combining non-invasive brain stimulation with psychotherapy DOI Creative Commons
Elisa Tatti, Angela Phillips,

Rachel Paciorek

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104867 - 104867

Published: Sept. 16, 2022

Language: Английский

Citations

34
Transcranial photobiomodulation in children aged 2–6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology DOI Creative Commons

Yuliy Fradkin,

Luis De Taboada,

Margaret Naeser

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: April 26, 2024

Small pilot studies have suggested that transcranial photobiomodulation (tPBM) could help reduce symptoms of neurological conditions, such as depression, traumatic brain injury, and autism spectrum disorder (ASD).

Language: Английский

Citations

8
Opportunities and obstacles in non-invasive brain stimulation DOI Creative Commons
Jake Toth, Danielle L. Kurtin, Méadhbh B. Brosnan

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 18, 2024

Non-invasive brain stimulation (NIBS) is a complex and multifaceted approach to modulating activity holds the potential for broad accessibility. This work discusses mechanisms of four distinct approaches non-invasively: electrical currents, magnetic fields, light, ultrasound. We examine dual stochastic deterministic nature its implications NIBS, highlighting challenges posed by inter-individual variability, nebulous dose-response relationships, biases neuroanatomical heterogeneity. Looking forward, we propose five areas opportunity future research: closed-loop stimulation, consistent intended target region, reducing bias, multimodal approaches, strategies address low sample sizes.

Language: Английский

Citations

7
Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring DOI Creative Commons
Luodan Yang, Yan Dong,

Chongyun Wu

et al.

Theranostics, Journal Year: 2020, Volume and Issue: 11(3), P. 1269 - 1294

Published: Dec. 16, 2020

Neonatal hypoxic-ischemic (HI) injury is a severe complication often leading to neonatal death and long-term neurobehavioral deficits in children. Currently, the only treatment option available for HI therapeutic hypothermia. However, necessary specialized equipment, possible adverse side effects, limited effectiveness of this therapy creates an urgent need development new methods. Photobiomodulation (PBM) has been shown be neuroprotective against multiple brain disorders animal models, as well human studies. effects PBM on remain unclear. Methods: Two-minutes (808 nm continuous wave laser, 8 mW/cm2 brain) was applied three times weekly abdomen pregnant rats from gestation day 1 (GD1) GD21. After right common carotid artery ligation, cortex- hippocampus-related behavioral due insult were measured using battery tests. The pretreatment infarct size; synaptic, dendritic, white matter damage; neuronal degeneration; apoptosis; mitochondrial function; fragmentation; oxidative stress; gliosis then assessed. Results: Prenatal significantly improved survival rate decreased size after insult. Behavioral tests revealed that prenatal alleviated cortex-related motor memory learning dysfunction. In addition, function integrity protected animals treated with PBM. Additional studies HI-induced neuroinflammation, stress, myeloid cell/astrocyte activation. Conclusion: exerts rats. Underlying mechanisms neuroprotection may include preservation function, reduction inflammation, stress. Our findings support use high-risk pregnancies alleviate or prevent perinatal period.

Language: Английский

Citations

40
Defining Surgical Terminology and Risk for Brain Computer Interface Technologies DOI Creative Commons
Eric C. Leuthardt, Daniel W. Moran, Tim Mullen

et al.

Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: March 26, 2021

With the emergence of numerous brain computer interfaces (BCI), their form factors, and clinical applications terminology to describe deployment associated risk has been vague. The terms “minimally invasive” or “non-invasive” have commonly used, but can vary widely based on factor anatomic location. Thus, taken together, there needs be a that best accommodates surgical footprint BCI attendant risks. This work presents semantic framework describes from procedural standpoint its profile. We propose extending common invasive/non-invasive distinction for systems accommodate three categories in which anatomically with patient whether not procedure is required deployment: (1) Non-invasive —BCI components do penetrate body, (2) Embedded —components are penetrative, deeper than inner table skull, (3) Intracranial –components located within skull possibly volume. Each class separate profile should considered when being applied given population. Optimally, balancing this need provides most ethical these emerging classes devices. As BCIs gain larger adoption, becomes standardized, having an improved, more precise language will better serve clinicians, patients, consumers discussing technologies, particularly context procedures.

Language: Английский

Citations

37
Transcranial photobiomodulation-induced changes in human brain functional connectivity and network metrics mapped by whole-head functional near-infrared spectroscopy in vivo DOI Creative Commons

Elizabeth L. Urquhart,

Hashini Wanniarachchi, Xinlong Wang

et al.

Biomedical Optics Express, Journal Year: 2020, Volume and Issue: 11(10), P. 5783 - 5783

Published: Sept. 13, 2020

Transcranial photobiomodulation (tPBM) with near-infrared light on the human head has been shown to enhance cognition. In this study, tPBM-induced effects resting state brain networks were investigated using 111-channel functional spectroscopy over whole head. Measurements collected and without 8-minute tPBM in 19 adults. Functional connectivity (FC) network metrics quantified Pearson’s correlation coefficients graph theory analysis (GTA), respectively, for periods of pre-, during, post-tPBM. Our results revealed that (1) enhanced information processing speed efficiency network, (2) increased FC significantly frontal-parietal shedding a better understanding networks.

Language: Английский

Citations

33