Deleted Journal,
Год журнала:
2022,
Номер
27(44), С. 84 - 100
Опубликована: Ноя. 1, 2022
Critically
ill
patients
frequently
experience
sleep
deprivation,
which
has
detrimental
effects
such
as
increased
pain
perception,
impaired
cognitive
function,
and
delirium.Aim:
Evaluate
the
effect
of
implementing
nursing
interventions
bundle
on
quality
associated
delirium
among
at
intensive
care
unit
(ICU).Design:
A
quasi-experimental
research
design
was
utilized
in
this
study.Setting:
Anesthesia
Intensive
Care
Unit
Emergency
hospital
affiliated
to
Tanta
University
hospital.Subjects:
Purposive
sampling
60
adult
critically
who
admitted
selected
setting
divided
into
two
equal
groups;
30
each
(control
study
groups).Tools;
Tool
(I)
Patient
interview
schedule,
tool
(II)
Richard
Campbell
Sleeping
Questionnaire
(RCSQ)
(III)
Delirium
Screening
Checklist
(ICDSC)
Results:
highly
significant
difference
detected
between
control
groups
regarding
their
total
after
applying
intervention
(
P=0.000).The
incidence
30%
group
compared
13.33%
seventh
day
with
differences
(P=0.024).Conclusion:
Implementing
can
improve
decrease
delirium.Recommendation:
Sleep
should
be
integrated
routine
for
ICU
promote
patient
reduce
delirium.
Biomolecules,
Год журнала:
2022,
Номер
12(11), С. 1646 - 1646
Опубликована: Ноя. 7, 2022
Clinical
sequelae
and
symptoms
for
a
considerable
number
of
COVID-19
patients
can
linger
months
beyond
the
acute
stage
SARS-CoV-2
infection,
“long
COVID”.
Among
long-term
consequences
cognitive
issues
(especially
memory
loss
or
“brain
fog”),
chronic
fatigue,
myalgia,
muscular
weakness
resembling
myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS)
are
importance.
Melatonin
may
be
particularly
effective
at
reducing
signs
infection
due
to
its
functions
as
an
antioxidant,
anti-inflammatory,
immuno-modulatory
agent.
is
also
chronobiotic
medication
in
treating
delirium
restoring
circadian
imbalance
seen
COVID
intensive
care
unit.
Additionally,
cytoprotector,
melatonin
aids
prevention
several
comorbidities,
including
diabetes,
metabolic
syndrome,
ischemic
non-ischemic
cardiovascular
diseases.
This
narrative
review
discusses
application
neuroprotective
agent
control
deterioration
(“brain
fog”)
pain
ME/CFS
syndrome-like
documented
long
COVID.
Further
studies
on
therapeutic
use
neurological
warranted.
Journal of Pineal Research,
Год журнала:
2023,
Номер
76(1)
Опубликована: Дек. 11, 2023
Abstract
Because
the
chronobiotic
and
cytoprotective
molecule
melatonin
diminishes
with
age,
its
involvement
in
postmenopausal
senescence
pathology
has
been
considered
since
long.
One
relevant
target
site
aging
individuals
is
bone
where
effects
mediated
by
MT1
MT2
receptors
are
demonstrable.
Precursors
of
cells
located
marrow
exposed
to
high
quantities
possibility
arises
that
acts
a
compound
via
an
autacoid
effect.
Proteins
incorporated
into
matrix,
like
procollagen
type
I
c‐peptide,
augment
after
exposure.
Melatonin
augments
osteoprotegerin,
osteoblastic
protein
inhibits
differentiation
osteoclasts.
Osteoclasts
for
as
they
degrade
partly
generating
free
radicals.
Osteoclast
activity
resorption
impaired
radical
scavenger
properties
melatonin.
The
administration
doses
(less
than
10
mg
daily)
commonly
used
clinical
studies
on
effect
bone.
However,
human
equivalent
allometrically
derived
from
animal
1–1.5
mg/kg/day
range
75
kg
adult,
dose
rarely
clinically.
In
view
absence
toxicity
phase
1
pharmacological
up
100
normal
volunteers,
further
investigation
needed
determine
whether
have
higher
therapeutic
efficacy
preventing
loss.
Molecules,
Год журнала:
2025,
Номер
30(9), С. 1888 - 1888
Опубликована: Апрель 23, 2025
Circadian
rhythms
are
molecular
oscillations
governed
by
transcriptional–translational
feedback
loops
(TTFLs)
operating
in
nearly
all
cell
types
and
fundamental
to
physiological
homeostasis.
Key
circadian
regulators,
such
as
locomotor
output
cycles
kaput
(CLOCK),
brain
muscle
ARNT-like
1
(BMAL1),
period
(PER),
cryptochrome
(CRY)
gene
families,
regulate
intracellular
metabolism,
oxidative
balance,
mitochondrial
function,
synaptic
plasticity.
disruption
is
known
a
central
contributor
the
pathophysiology
of
neurodegenerative
disorders.
Disease-specific
disruptions
clock
expression
melatoninergic
signaling
potential
early-stage
biomarkers.
Melatonin,
neurohormone
secreted
pineal
gland,
modulates
expression,
stability,
inflammatory
responses.
It
also
regulates
epigenetic
metabolic
processes
through
nuclear
receptors
regulators
involved
cellular
stress
pathways,
thereby
exerting
neuroprotective
effects
maintaining
neuronal
integrity.
This
review
provides
recent
findings
from
past
five
years,
highlighting
how
dysregulation
mediates
key
disturbances
translational
circadian-based
therapies
diseases.
Journal of Pineal Research,
Год журнала:
2025,
Номер
77(4)
Опубликована: Июнь 1, 2025
ABSTRACT
Melatonin
is
a
versatile
neurohormone
with
diverse
molecular
functions,
including
sleep
regulation,
inflammation
reduction,
antioxidant
activity,
immune
modulation,
and
anticancer
properties.
In
bone
metabolism,
it
promotes
osteoblast
formation,
inhibits
osteoclast
synchronizes
skeletal
tissue
rhythms
to
support
health.
As
melatonin
not
yet
clinically
used
for
osteoporosis
concerns
about
the
current
treatments'
side
effects
remain,
this
review
highlights
its
role
in
modulating
interactions,
particularly
through
regulation
of
receptor
activator
nuclear
factor‐κB
ligand
osteoprotegerin,
achieve
bone‐forming
antiresorptive
effects.
These
have
been
demonstrated
across
various
concentrations
cell
types
Vivo
models.
Furthermore,
safeguards
microenvironment
by
mitigating
oxidative
stress
inflammation,
protecting
osteoblasts,
preventing
loss,
maintaining
gut
microbiota
brain–gut–bone
axis.
attributes
underscore
melatonin's
potential
as
an
effective
alternative
or
complementary
therapy
promoting
health
managing
osteoporosis.
Future
research
needed
determine
optimal
dosing
timing
maximum
efficacy.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Год журнала:
2023,
Номер
19(2), С. 143 - 148
Опубликована: Апрель 29, 2023
Diabetes
mellitus
(DM)
and
its
complications
are
one
of
the
leading
causes
death
worldwide,
with
approximately
700
million
people
expected
to
suffer
from
DM
by
2045,
according
International
Federation.
is
a
progressive,
chronic
disease
that
affects
various
body
systems
can
lead
serious
physical
health
complications.
Type
2
diabetes
(T2DM)
has
been
shown
be
associated
higher
incidence
sleep
disturbances,
which
may
due
itself
or
secondary
comorbidities
DM.
However,
epidemiological
evidence
suggests
risk
obesity,
metabolic
syndrome,
T2DM
in
individuals
shorter
duration
poor
quality
sleep.
Therefore,
an
assessment
sleep,
disorders
their
pharmacological
correction
recommended
as
comprehensive
medical
examination
for
existing
groups
at
development.
Among
pharmacotherapeutic
agents
treatment
disorders,
melatonin
(N-acetyl-5-methoxytryptamine)
attracts
special
attention.
It
indoleamine,
pineal
hormone
synthesized
human
body,
name
related
ability
aggregate
melanin
pigment
granules.
found
directly
participates
many
biological
processes
limits
oxidative
stress
both
extracellularly
intracellularly.
Endogenous
linear
kinetics,
half-life
usual
form
rapid
release
ranges
45
65
minutes,
it
quickly
metabolized
completely
excreted
after
3–4
hours.
Currently,
1
mg
prolonged-release
forms
available,
provide
slower
longer
absorption,
delayed
lower
peak
dose,
levels
maintained
8
10
hours—
similar
physiological
secretion
curve
endogenous
melatonin.
Since
dose
much
than
immediate
forms,
this
will
help
reduce
possible
side
effects,
including
patients
