The Effect of Modified Qiyuan Paste on Mice with Low Immunity and Sleep Deprivation by Regulating GABA Nerve and Immune System DOI Creative Commons

Mei Rong,

Jiu Jie Jia,

Min Qiu Lin

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 6, 2024

Abstract Background Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, rendering them more susceptible to the infiltration of pathogenic factors. LJC is obtained by modifing Qiyuan Paste, a traditional Chinese medicine formula for nourishing Yin blood calming mind with long history. Studies have shown that Dendrobium officinale can improve immune function deprivation mice. Based on (TCM) theory, was prepared adding Paste Decoction. Methods Yin deficiency syndrome indicators such as back temperature grip strength mice each group were measured, behavioral tests pentobarbital sodium induced test performed. Automatic biochemical analyzer, enzyme-linked immunosorbent assay (ELISA) kit other methods used detect routine, serum immunoglobulin (IgG, IgA, IgM), complement (C3, C4, ACP) LDH content spleen, hemolysin delayed hypersensitivity (DTH) levels. The levels γ-aminobutyric acid (GABA) glutamate (Glu) detected high performance liquid chromatography (HPLC). Hematoxylin-eosin (H&E) staining Nissl evaluate histological changes hypothalamus tissue. Western blot immunohistochemistry expression GABA pathway proteins GABRA1, GAD, GAT1, GABAT1, CD4+ CD8+ thymus spleen tissues. Results Of note, could prolong duration, improved pathological hippocampus, effectively up-regulated brain mice, down-regulated Glu Glu/GABA ratio, increased GAD decreased GABAT1 disorders. Importantly, damaged tissues model increase activities ACP immunocompromised At same time, levels, IgG, IgM after administration , manifested content, enhanced delayed-type response. In addition, significantly C3 number white cells lymphocytes blood, percentage neutrophils. Conclusions LJC insufficient sleep. mechanism may be regulate GABA/Glu metabolism related enhance specific non-specific functions

Язык: Английский

COVID-19 and Sleep Disturbances: A Literature Review of Clinical Evidence DOI Creative Commons

Likhita Shaik,

Sydney Boike,

Kannan Ramar

и другие.

Medicina, Год журнала: 2023, Номер 59(5), С. 818 - 818

Опубликована: Апрель 22, 2023

The need for adequate good quality sleep to optimally function is well known. Over years, various physical, psychological, biological, and social factors have been investigated understand their impact on sleep. However, understanding the etiological processes that are involved in causing disturbances (SD) as impacted by stressful phases such pandemics has not studied. Many management strategies surfaced during latest “coronavirus disease of 2019 (COVID-19) pandemic. occurrence these SD infected uninfected individuals poses a investigate linked this phase. Some include practices distancing, masking, vaccines, medications availability, changes routines, lifestyles. As status infection improved, collective term all prolonged effects COVID-19 after resolution primary called post-COVID-19 syndrome (PCS) surfaced. Apart from impacting infectious phase, aftereffects virus left an even greater PCS. Various mechanisms hypothesized be PCS, but available data inconclusive. Further, varied patterns incidence SDs differed many factors, age, gender, geographical location, making clinical more challenging. This review elucidates coronavirus 2 (SARS-CoV-2) (COVID) health We also different causal relationships, strategies, knowledge gaps related

Язык: Английский

Процитировано

20
The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system DOI Creative Commons

Mei Rong,

Jiujie Jia,

Min-Qiu Lin

и другие.

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Июнь 12, 2024

Abstract Background Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, which render them susceptible to the infiltration of pathogenic factors. LJC, has a long history traditional Chinese medicine for nourishing Yin blood calming mind, is obtained by modifying Qiyuan paste. Dendrobium officinale Kimura et Migo been shown improve immune function sleep-deprived mice. In this study, based on theory, LJC was prepared adding D. paste decoction. Methods Indicators deficiency syndrome, such as back temperature grip strength, were measured each group mice; furthermore, behavioral tests pentobarbital sodium-induced performed. An automatic biochemical analyzer, enzyme-linked immunosorbent assay kit, other methods used determine routine parameters, serum immunoglobulin (IgG, IgA, IgM), cont (C3, C4), acid phosphatase (ACP) lactate dehydrogenase (LDH) levels spleen, hemolysin, delayed-type hypersensitivity (DTH) levels. addition, γ-aminobutyric (GABA) glutamate (Glu) detected using high-performance liquid chromatography (HPLC). Hematoxylin–eosin staining Nissl assess histological alterations hypothalamus tissue. Western blot immunohistochemistry detect expressions GABA pathway proteins GABRA1, GAD, GAT1, GABAT1 those CD 4+ 8+ thymus spleen tissues. Results The findings indicated that prolonged duration, improved pathological changes hippocampus, effectively upregulated content mice, downregulated Glu Glu/GABA ratio, enhanced decreased expression assuage disorders. Importantly, alleviated damage tissues model mice activities ACP LDH immunocompromised Moreover, hemolysin IgG, IgM increased after administration, manifested content, DTH response. significantly complement C3 C4, number white cells lymphocytes, percentage neutrophils blood. Conclusions can lead improvements models with insufficient sleep. underlying mechanism may involve regulation GABA/Glu metabolism pathway-related brain enhancing their specific nonspecific functions. Graphical

Язык: Английский

Процитировано

3
Analysis of risk factors and construction of a prediction model for posttraumatic stress disorder among Chinese college students during the COVID-19 pandemic DOI

Guangjian Li,

Xugui Sun,

Tingye Gao

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 362, С. 230 - 236

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

2
The Association Between Lifestyle Factors and COVID-19 Among Older Adults in Southern California: The Loma Linda Longevity Study DOI
Alaa Alabadi-Bierman,

Rhonda Spencer-Hwang,

W. Lawrence Beeson

и другие.

Journal of Applied Gerontology, Год журнала: 2024, Номер 43(10), С. 1560 - 1569

Опубликована: Март 31, 2024

Amid a global aging trend, particularly notable in the U.S., there is growing focus on achieving enhanced longevity and well-being. We evaluated association between lifestyle factors (sleep, diet, healthy index) COVID-19 infection an older adult population San Bernardino Riverside counties Southern California, United States. A sample of 380 adults ≥75 years old were surveyed cross-sectionally self-reported behaviors infection. The results revealed that half participants reported Participants who slept less than 7 hours or more 8 hours/night had higher odds those 7–8 (OR = 1.62, 95% CI: 1.03, 2.55). Healthy significantly associated with reduced 0.61, 0.40, 0.92). In conclusion, adequate sleep may be protective against among should investigated further.

Язык: Английский

Процитировано

1
Shift Work, Sleep and Well-Being: A Qualitative Study on the Experience of Rotating Shift Workers DOI
Moitrayee Das, Sasmita Palo

Management and Labour Studies, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

This study critically investigates the impact of sleep deprivation on well-being shift workers in a Mumbai-based manufacturing facility, highlighting significant yet often overlooked occupational health concern. Employing robust, two-phase mixed-methods approach, phase 1 quantitatively assessed patterns, quality and daytime sleepiness 85 shop floor using diaries, Fitbit wristbands, Actigraphy validated tools such as Epworth Sleepiness Scale Pittsburgh Sleep Quality Index. Phase 2 comprised in-depth qualitative interviews with 14 experiencing poor sleep, alongside four plant managers family members. Thematic analysis interview data revealed compelling narrative: work fundamentally disrupts circadian rhythms, precipitating irregular chronic marked decline workers’ physical psychological well-being. The also identifies effective strategies to mitigate adverse effects work. It contributes valuable insights, proposing framework for future studies develop targeted, evidence-based interventions that address critical issue among workers.

Язык: Английский

Процитировано

1
Alteration of white matter microstructure in patients with sleep disorders after COVID-19 infection DOI

Haixia Qin,

Gaoxiong Duan,

Kaixuan Zhou

и другие.

Sleep Medicine, Год журнала: 2023, Номер 114, С. 109 - 118

Опубликована: Дек. 26, 2023

Язык: Английский

Процитировано

1
The Effect of Modified Qiyuan Paste on Mice with Low Immunity and Sleep Deprivation by Regulating GABA Nerve and Immune System DOI Creative Commons

Mei Rong,

Jiu Jie Jia,

Min Qiu Lin

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 6, 2024

Abstract Background Low immunity and sleep disorders are prevalent suboptimal health conditions in contemporary populations, rendering them more susceptible to the infiltration of pathogenic factors. LJC is obtained by modifing Qiyuan Paste, a traditional Chinese medicine formula for nourishing Yin blood calming mind with long history. Studies have shown that Dendrobium officinale can improve immune function deprivation mice. Based on (TCM) theory, was prepared adding Paste Decoction. Methods Yin deficiency syndrome indicators such as back temperature grip strength mice each group were measured, behavioral tests pentobarbital sodium induced test performed. Automatic biochemical analyzer, enzyme-linked immunosorbent assay (ELISA) kit other methods used detect routine, serum immunoglobulin (IgG, IgA, IgM), complement (C3, C4, ACP) LDH content spleen, hemolysin delayed hypersensitivity (DTH) levels. The levels γ-aminobutyric acid (GABA) glutamate (Glu) detected high performance liquid chromatography (HPLC). Hematoxylin-eosin (H&E) staining Nissl evaluate histological changes hypothalamus tissue. Western blot immunohistochemistry expression GABA pathway proteins GABRA1, GAD, GAT1, GABAT1, CD4+ CD8+ thymus spleen tissues. Results Of note, could prolong duration, improved pathological hippocampus, effectively up-regulated brain mice, down-regulated Glu Glu/GABA ratio, increased GAD decreased GABAT1 disorders. Importantly, damaged tissues model increase activities ACP immunocompromised At same time, levels, IgG, IgM after administration , manifested content, enhanced delayed-type response. In addition, significantly C3 number white cells lymphocytes blood, percentage neutrophils. Conclusions LJC insufficient sleep. mechanism may be regulate GABA/Glu metabolism related enhance specific non-specific functions

Язык: Английский

Процитировано

0