Correlation Between PhenoAgeAccel and Clinical Outcomes in Atrial Fibrillation Patients Undergoing Radiofrequency Catheter Ablation
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 6293 - 6304
Опубликована: Май 1, 2025
To
investigate
the
relationship
between
phenotypic
age
(PhenoAge)
and
accelerated
(PhenoAgeAccel)
recurrence
of
atrial
fibrillation
(AF)
in
patients
after
radiofrequency
catheter
ablation
(RFCA).
Preoperative
PhenoAge
PhenoAgeAccel
were
determined
AF
undergoing
RFCA.
We
used
logistic
regression
models
subgroup
analysis
to
study
risk
recurrence.
As
for
revealing
value
predicting
recurrence,
ROC
curve
was
performed.
further
detect
enhancement
role
APPLE
score
a
model
established
factors
C-statistics,
net
reclassification
improvement
(NRI),
integrated
discrimination
(IDI)
conducted.
A
total
322
with
who
underwent
RFCA
our
hospital
included
present
study.
The
mean
follow-up
period
21
months.
frequency
increased
gradually
as
index
rose.
optimal
cut-off
-0.338.
Patients
≥
-0.338
had
significantly
greater
likelihood
experiencing
recurrent
than
those
<-0.338
(OR
3.989,
95%
CI
2.006-7.933,
p
<
0.001).
association
also
reflected
each
subgroup.
Incorporating
into
existing
may
result
enhancements
NRI
IDI
(p<0.05),
respectively.
positively
independently
associated
following
Язык: Английский
Inflammatory Burden Index Associated with Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation
Si-Liang Peng,
Feng Li,
Mengchao Jin
и другие.
Therapeutics and Clinical Risk Management,
Год журнала:
2025,
Номер
Volume 21, С. 681 - 689
Опубликована: Май 1, 2025
Recurrence
rates
of
atrial
fibrillation
(AF)
remain
high
after
radiofrequency
catheter
ablation
(RFCA),
and
inflammation
plays
an
important
role
in
the
process.
Inflammatory
burden
index
(IBI)
as
a
new
inflammatory
marker
has
been
found
to
be
associated
with
worse
prognosis
cardiovascular
disease.
But
there
are
no
studies
on
its
predicting
AF
recurrence.
The
aim
this
study
was
assess
value
IBI
recurrence
RFCA.
This
single-center
retrospective
observational
study.
Consecutive
enrolment
PersAF
who
underwent
first-time
between
January
2021
June
2024.
Burden
Index
calculated
C-reactive
protein
(CRP)
×
neutrophil/lymphocyte
(NLR).
A
total
142
(27.2%)
patients
experienced
Multivariate
analysis
showed
that
(OR
=
1.599;
95%
CI:
1.028
~
2.486,
p
0.018),
CHA2DS2-VASc
score≥2
1.769;
1.142
2.741,
0.011),
LAD
1.098;
1.054
1.145,
<
0.001)
1.028;
1.007
1.050,
0.009),
were
independent
predictors
ROC
shows
superiority
(AUC=0.695,
0.647
0.743,
over
CRP
NLR
When
integrated
into
traditional
model
(including
PersAF,
Score),
discrimination
reclassification
accuracy
for
significantly
improved.
load
Integration
can
improve
about
Язык: Английский
Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients
Future Cardiology,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Янв. 28, 2025
Decreased
left
atrial
appendage
emptying
velocity
(LAAV)
is
a
marker
for
thrombus
formation.
This
study
evaluates
the
association
between
LAAV
and
inflammatory
indices
in
non-valvular
fibrillation
(AF)
patients.
The
population
was
1428
patients
with
AF,
875
of
whom
enrolled.
Based
on
LAAV,
were
divided
into
three
groups
262
<25
cm/s,
360
25
to
55
253
>55
cm/s
assess
compare
terms
indices,
including
platelet-to-lymphocyte
ratio,
neutrophil-to-lymphocyte
systemic
immune
inflammation
index,
neutrophil
-
platelet
ratio
white
blood
cell-to-platelet
(WPR).
There
no
statistical
difference
level
groups,
none
them
related
(p
>
.05)
except
WPR
weak
negative
correlation
=
0.01,
r
-0.10).
Patients
lower
found
have
higher
age
0.001),
decreased
ventricular
ejection
fraction
0.001)
greater
volume
index
0.001).
did
not
show
any
AF
WPR.
Язык: Английский
A Shocking Outcome: Cardioversion-Induced Flash Pulmonary Edema
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Atrial
fibrillation
(AF)
is
the
most
common
major
cardiac
rhythm
disorder
in
adults
and
causes
considerable
morbidity
mortality,
particularly
elderly
patients.
We
present
case
of
a
75-year-old
female
admitted
for
acute
heart
failure
with
history
AF
recurrent
exacerbations.
Despite
aggressive
medical
management
amiodarone
diuretics,
patient
continued
to
deteriorate.
The
cardiology
team
recommended
electrical
cardioversion
re-establish
normal
sinus
rhythm.
By
doing
so,
developed
flash
pulmonary
edema
after
procedure
required
immediate
intubation
mechanical
ventilation.
There
was
need
tracheostomy
facilitate
prolonged
ventilatory
support
some
time.
Over
time,
they
were
weaned
off
ventilator
discharged
home
full
recovery.
This
illustrates
challenges
managing
an
possible
risks
due
cardioversion.
Язык: Английский
Relationship Between Epicardial Adipose Tissue and Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Introduction
and
aim:
Heart
failure
with
preserved
ejection
fraction
(HFpEF)
is
a
significant
clinical
challenge,
often
coexisting
atrial
fibrillation
(AF),
which
exacerbates
patient
outcomes
by
increasing
risks
of
stroke,
hospitalizations,
mortality.
Recent
studies
suggest
that
epicardial
adipose
tissue
(EAT),
metabolically
active
fat
depot,
may
contribute
to
AF
pathogenesis
promoting
remodeling
fibrosis.
This
study
aimed
evaluate
the
relationship
between
EAT
thickness
in
HFpEF
patients.
Materials
methods:
A
total
110
patients
were
included,
20
(18.2%)
having
documented
AF.
was
measured
using
transthoracic
echocardiography,
confirmed
via
electrocardiography.
Results:
Patients
had
significantly
greater
compared
those
without
(8.3
±
0.9
mm
vs.
7.1
0.8
mm,
p
<
0.001).
Receiver
operating
characteristic
(ROC)
analysis
demonstrated
strong
predictor
(AUC
=
0.87,
0.001),
cut-off
value
7.5
achieving
89%
sensitivity
75%
specificity.
Conclusion:
These
findings
indicate
increased
independently
associated
patients,
highlighting
its
potential
as
biomarker
for
risk
stratification.
Future
should
explore
whether
targeting
could
improve
this
high-risk
population.
Язык: Английский
Effect of atrial fibrosis on clot burden score and physicochemical properties of thrombus in patients with ischaemic stroke occurring in non-valvular atrial fibrillation
PeerJ,
Год журнала:
2025,
Номер
13, С. e19173 - e19173
Опубликована: Март 24, 2025
Background
To
investigate
the
effect
of
degree
atrial
fibrosis
on
clot
burden
score
(CBS)
and
physicochemical
properties
in
patients
with
acute
ischaemic
stroke
(AIS)
due
to
non-valvular
fibrillation
(NVAF).
Methods
A
total
117
AIS
NVAF
attending
Department
Cardiovascular
Medicine
Cerebrovascular
Diagnostic
Treatment
Centre
between
August
2021
May
2024
were
included
study.
Baseline
clinical
data,
biochemical
indexes,
imaging
data
collected,
divided
into
93
cases
CBS
(score
0–6)
group
24
7–10)
according
CBS.
signifies
higher
burden.
The
enzyme-linked
immunosorbent
assay
was
used
measure
concentration
galactaglutinin-3
(gal-3)
transforming
growth
factor
(TGF-β1)
serum
patients,
PTFV1
collected
by
12-lead
electrocardiogram,
differences
different
groups
risk
factors
analysed.
analyse
collateral
circulation
stroke,
31
good
(grade
3–4)
86
poor
0–2)
digital
subtraction
angiography
(DSA)
images.
cerebral
thrombus
from
60
who
underwent
mechanical
thrombectomy.
content
erythrocyte,
fibrin/platelets
leukocytes
analysed
Mathew’s
scarlet
blue
staining,
density
measured
computed
tomography
(CT).
Results
this
study,
proportion
hypertensive
chronic
(CAF),
B-type
natriuretic
peptide
(BNP),
neutrophil/lymphocyte
ratio
(NLR),
D-dimer,
uric
acid
concentration,
<
−0.03
mm
s,
gal-3,
TGF-β1
as
compared
(
P
-value
0.05).
Hypertension,
CAF,
homocysteine,
NLR,
acid,
TGF-β1,
for
development
high
(AF),
hypertension
CAF
most
important
occurrence
AF
independent
combined
gal-3
circulation,
indexes
not
associated
pathological
composition
density.
Conclusions
Atrial
increases
but
does
significantly
correlate
thrombus.
Язык: Английский
Beyond Atrial Fibrillation: Prioritizing Stroke Evaluation in Resource-Limited Settings
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Язык: Английский
Association of glucagon-like peptide-1 receptor agonists with atrial fibrillation, cardiac arrest, and ventricular fibrillation: Casual evidence from a drug target Mendelian randomization
Diabetology & Metabolic Syndrome,
Год журнала:
2025,
Номер
17(1)
Опубликована: Май 29, 2025
Язык: Английский