International Journal of Bipolar Disorders,
Год журнала:
2024,
Номер
12(1)
Опубликована: Дек. 23, 2024
Abstract
Background
The
rate
of
suicide
attempts
by
patients
with
bipolar
disorder
is
high.
In
addition
to
patient
and
country
specific
factors,
environmental
factors
may
contribute
suicidal
behavior.
Sunlight
has
multiple
diverse
impacts
on
human
physiology
Solar
insolation
defined
as
the
electromagnetic
energy
from
sun
striking
a
surface
area
earth.
We
previously
found
that
large
change
in
solar
between
minimum
maximum
monthly
values
was
associated
an
increased
risk
I
disorder.
Methods
association
history
again
investigated
using
international
database
15%
more
data
sites
at
locations
countries.
Results
Data
were
available
5641
living
wide
range
latitudes
41
countries
both
hemispheres.
A
disorder,
replication
our
prior
analysis.
estimated
model
also
state
sponsored
religion
onset
country,
female
gender,
alcohol
or
substance
abuse,
being
part
younger
birth
cohort
attempts.
Conclusions
replicating
research.
Physicians
should
be
aware
daylight
ranging
physiological
psychiatric
impacts,
changes
risk.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2410 - 2410
Опубликована: Апрель 1, 2025
Background:
Vitamin
D
plays
a
crucial
role
in
immune
system
function,
and
its
deficiency
has
been
associated
with
an
increased
risk
of
infections.
This
study
investigates
the
relationship
between
vitamin
severity
purulent
oropharyngeal
infections,
considering
need
for
surgical
interventions
duration
hospitalization.
Materials
Methods:
retrospective
included
patients
diagnosed
peritonsillar
phlegmons,
laterocervical
abscesses,
abscesses.
Patients
were
categorized
based
on
their
levels:
(<30
ng/mL)
optimal
levels
(≥30
ng/mL).
The
clinical
parameters,
length
hospitalization,
type
treatment
analyzed.
Statistical
analyses
Student's
t-test,
chi-square
test,
ANOVA
to
assess
differences
groups.
Results:
(25(OH)D3)
had
significantly
longer
hospital
stay
(8.50
days
vs.
3.24
days,
p
=
0.001)
required
more
frequent
(55.6%
27.8%,
0.002)
compared
those
levels.
A
trend
toward
complex
regimens
was
also
observed,
although
this
not
statistically
significant
(p
>
0.05).
Conclusions:
These
findings
suggest
that
may
contribute
severe
course
increasing
invasive
treatments
prolonging
highlights
importance
monitoring
potential
benefits
supplementation
preventing
managing
upper
respiratory
tract
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2467 - 2467
Опубликована: Апрель 4, 2025
Chronic
rhinosinusitis
with
nasal
polyps
(CRSwNP)
is
a
subtype
of
chronic
(CRS)
characterized
by
bilateral
polyps,
primarily
affecting
adults.
It
often
associated
hyposmia
and
asthma
driven
persistent
Th2
inflammation,
particularly
in
Caucasian
patients.
The
disease
recurrent
significantly
impacts
quality
life,
yet
its
pathophysiology
remains
poorly
understood.
Management
includes
intranasal
steroids,
short
courses
systemic
corticosteroids,
surgery
for
refractory
cases,
biologics.
However,
despite
these
treatment
options,
control
challenging.
Low
vitamin
D
levels
have
been
worse
clinical
outcomes,
while
supplementation
studies
show
promise
improving
symptoms
deficient
Emerging
research
suggests
that
modulates
immunity,
fibroblast
activity,
epithelial
integrity,
potentially
contributing
to
CRSwNP
pathogenesis,
though
the
exact
mechanisms
remain
unclear.
This
review
synthesizes
current
on
D's
role
local
inflammation
CRSwNP.
By
highlighting
potential
therapeutic
implications,
this
work
aims
guide
future
inform
practice.
Additionally,
it
may
serve
as
foundation
understanding
broader
impact
deficiency
sinonasal
diseases
other
atopic
conditions.
Previous
studies
indicate
vitamin
D
impacts
autism
spectrum
disorder
(ASD),
but
its
relationship
with
brain
function
is
unclear.
This
study
investigated
the
association
between
serum
25-hydroxyvitamin
[25(OH)D]
levels
and
in
preschool
children
ASD
using
resting-state
functional
magnetic
resonance
imaging
(rs-fMRI),
explored
correlations
clinical
symptoms.
A
total
of
226
patients
underwent
rs-fMRI
scanning
25(OH)D
testing.
Clinical
symptoms
were
assessed
Childhood
Autism
Rating
Scale
(CARS)
Behavior
Checklist
(ABC).
Patients
categorized
into
mild
severe
groups
based
on
CARS,
further
divided
normal
(NVD),
insufficient
(VDI),
deficient
(VDD)
levels.
Changes
among
these
analyzed
regional
homogeneity
(ReHo),
ABC
scores
used
for
correlation
analysis.
In
ASD,
ReHo
increased
right
postcentral
gyrus
left
precuneus
VDI
VDD
compared
to
NVD,
decreased
bilateral
middle
cingulate
superior
frontal
group
VDI.
occipital
insula
Correlation
analysis
revealed
that
was
positively
correlated
body
object
use
NVD
groups,
while
negatively
relating
groups.
language
lower
show
multiple
abnormalities,
specific
region
alterations
linked
symptom
severity.
These
findings
enhance
our
understanding
D's
impact
suggest
future
research
may
explore
therapeutic
potential.
Nursing and Health Sciences,
Год журнала:
2025,
Номер
27(1)
Опубликована: Март 1, 2025
ABSTRACT
This
study
examined
the
relationship
between
nutritional
intake
and
mental
health,
focusing
on
depressive
symptoms
among
older
adults
in
rural
areas.
Using
data
from
2022
Korea
National
Health
Nutrition
Examination
Survey
(KNHANES),
of
465
individuals
aged
65
was
analyzed
against
recommended
nutrient
intakes
(RNI).
Mental
health
assessed
using
PHQ‐9
GAD‐7
scales,
with
logistic
regression
identifying
predictors
symptoms.
Results
showed
deficiencies
essential
vitamins,
including
A,
B3
(niacin),
C,
D,
E.
Higher
niacin
(≥
5
mg/day)
Vitamin
E
mg
α‐TE/day)
were
associated
reduced
Energy,
protein,
fiber
also
negatively
correlated
symptoms,
emphasizing
importance
overall
balance.
Interestingly,
C
positively
anxiety
suggesting
complex
diet
–mental
interactions.
Implications
for
clinical
practice
highlight
integrated
screening
interventions,
particularly
underserved
communities.
However,
given
observational
nature
this
study,
further
research
is
to
establish
causality
explore
effectiveness
targeted
supplementation
programs.
Archiv der Pharmazie,
Год журнала:
2024,
Номер
357(9)
Опубликована: Май 20, 2024
Abstract
Epilepsy
is
a
noncommunicable
chronic
neurological
disorder
affecting
people
of
all
ages,
with
the
highest
prevalence
in
low
and
middle‐income
countries.
Despite
pharmacological
armamentarium,
plethora
drugs
market,
other
treatment
options,
30%–35%
individuals
still
show
resistance
to
current
medication,
termed
intractable
epilepsy/drug
epilepsy,
which
contributes
50%
mortalities
due
epilepsy.
Therefore,
development
new
agents
needed
manage
this
devastating
We
reviewed
pipeline
“ClinicalTrials.
gov,”
federal
registry
clinical
trials
identify
options
various
phases
against
A
total
31
were
found
regarding
Among
them,
48.4%
(15)
are
about
agents,
26.6%
Phase
1,
60%
2,
13.3%
3.
The
mechanism
action
or
targets
majority
these
different
more
diversified
than
those
approved
drugs.
In
article,
we
summarized
trials,
their
backgrounds,
targets,
mechanisms
for
Treatment
ones,
such
as
devices
brain
stimulation,
ketogenic
diets,
gene
therapy,
others,
also
summarized.
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 21, 2024
Abstract
Context
Despite
the
well-established
regulatory
role
of
vitamin
D
in
maintaining
bone
health,
little
is
known
about
shared
genetics
and
causality
association
between
serum
25-hydroxyvitamin
(25OHD)
mineral
density
(BMD).
Objective
We
aimed
to
investigate
genetic
architecture
causal
relationship
25OHD
BMD,
providing
insights
into
their
underlying
biological
mechanisms.
Methods
Leveraging
individual-level
data
from
UK
Biobank
(UKB)
cohort
summary-level
genome-wide
studies
(GWASs)
conducted
on
European
individuals
for
(N
=
417
580)
estimated
heel
BMD
(eBMD,
N
426
824),
we
systematically
elucidated
eBMD
through
a
comprehensive
cross-trait
design.
Results
lack
global
correlation
(rg=−0.001;
P
.95),
statistically
significant
local
signal
was
discovered
at
5p11-5q11.9.
Two-sample
mendelian
randomization
(MR)
indicated
no
overall
population
(β=.003,
95%
CI,
−0.04
0.03;
.93),
while
positive
effects
were
observed
males
(β=.005,
0.00
0.01;
.03)
older
(β=.009,
0.00∼0.02;
.01)
according
one-sample
MR.
A
total
49
pleiotropic
single-nucleotide
variations
(SNVs),
with
4
novel
SNVs
(rs1077151,
rs79873740,
rs12150353,
rs4760401),
identified,
95
gene-tissue
pairs
exhibited
overlap,
predominantly
enriched
nervous,
digestive,
exocrine/endocrine,
cardiovascular
systems.
Protein-protein
interaction
analysis
identified
RPS9
RPL7A
as
hub
genes.
Conclusion
This
study
illuminates
potential
health
benefits
enhancing
levels
mitigate
risk
osteoporosis
among
men
than
65
years.
It
also
unveils
basis
eBMD,
offering
valuable
intricate
pathways.
Multiple
sclerosis
(MS)
is
an
immune-mediated
disease
characterized
by
inflammation,
demyelination,
and
neurodegeneration
within
the
central
nervous
system.
Brain
plasticity,
brain's
ability
to
adapt
its
structure
function,
plays
a
crucial
role
in
mitigating
MS's
impact.
This
paper
explores
potential
benefits
of
lifestyle
changes
nutraceuticals
on
brain
plasticity
MS
patients.
Lifestyle
modifications,
including
physical
activity
dietary
adjustments,
can
enhance
upregulating
neurotrophic
factors,
promoting
synaptogenesis,
reducing
oxidative
stress.
Nutraceuticals,
such
as
vitamin
D,
omega-3
fatty
acids,
antioxidants
like
alpha-lipoic
acid,
have
shown
promise
supporting
health
through
anti-inflammatory
neuroprotective
mechanisms.
Regular
has
been
linked
increased
levels
brain-derived
factor
(BDNF)
improved
cognitive
function.
Dietary
interventions,
caloric
restriction
intake
polyphenols,
also
positively
influence
plasticity.
Integrating
these
into
management
could
provide
complementary
approach
traditional
therapies,
potentially
improving
neurological
outcomes
enhancing
quality
life
for
