Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1202 - 1202
Опубликована: Сен. 13, 2024
Gallic
acid
(GA)
is
a
well-known
herbal
bioactive
compound
found
in
many
herbs
and
foods
like
tea,
wine,
cashew
nuts,
hazelnuts,
walnuts,
plums,
grapes,
mangoes,
blackberries,
blueberries,
strawberries.
GA
has
been
reported
for
several
pharmacological
activities,
such
as
antioxidant,
inflammatory,
antineoplastic,
antimicrobial,
etc.
Apart
from
its
incredible
therapeutic
benefits,
it
associated
with
low
permeability
bioavailability
issues,
limiting
their
efficacy.
belongs
to
BCS
(Biopharmaceutics
classification
system)
class
III
(high
solubility
probability).
In
this
context,
novel
drug
delivery
approaches
played
vital
role
resolving
these
issues.
Nanocarrier
systems
help
improve
moiety’s
physical
chemical
stability
by
encapsulating
them
into
lipidic
or
polymeric
matrix
core
system.
regard,
researchers
have
developed
wide
range
of
nanocarrier
GA,
including
liposomes,
transfersomes,
niosomes,
dendrimers,
phytosomes,
micelles,
nanoemulsions,
metallic
nanoparticles,
solid
lipid
nanoparticles
(SLNs),
nanostructured
carriers,
polymer
conjugates,
the
present
review,
different
search
engines
Scopus,
PubMed,
ScienceDirect,
Google
Scholar
referred
acquiring
recent
information
on
theme
work.
Therefore,
review
paper
aims
emphasize
systems,
patents,
clinical
updates
GA.
Язык: Английский
Navigating liver cancer: Precision targeting for enhanced treatment outcomes
Drug Delivery and Translational Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Язык: Английский
Rod and spherical selenium nanoparticles: Physicochemical properties and effects on red blood cells and neutrophils
Biochimica et Biophysica Acta (BBA) - General Subjects,
Год журнала:
2025,
Номер
1869(5), С. 130777 - 130777
Опубликована: Фев. 19, 2025
Язык: Английский
Selenoprotein GPX3 is a novel prognostic indicator for stomach adenocarcinoma and brain low-grade gliomas: Evidence from an integrative pan-cancer analysis
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32271 - e32271
Опубликована: Июнь 1, 2024
BackgroundThe
antioxidant
enzyme
GPX3
is
a
selenoprotein
that
transports
selenium
in
blood
and
maintains
its
levels
peripheral
tissues.
Aberrant
expression
strongly
linked
to
the
development
of
some
tumors.
However,
there
scarcity
studies
examining
pan-cancer
patterns
prognostic
relevance
GPX3.MethodsGPX3
normal
tissues
multiple
tumors
were
analyzed
using
TCGA,
CCLE,
GTEx,
UALCAN
HPA
databases.
Forest
plots
KM
survival
curves
utilized
evaluate
correlation
between
outcome
tumor
patients.
The
value
LGG
was
assessed
utilizing
CGGA
datasets,
STAD
tested
by
TCGA
GEO
A
nomogram
then
constructed
predict
OS
R
software.
Additionally,
impact
on
post-chemoradiotherapy
patients
with
evaluated
method.
multiplicative
interaction
expression,
chemotherapy
radiotherapy
logistic
regression
models.
immune
infiltration,
neoantigens
MMR
genes
investigated
cohort.ResultsGPX3
exhibited
downregulation
across
21
types,
including
STAD,
decreased
significantly
associated
improved
OS,
DFS,
PFS
DSS.
Conversely,
LGG,
low
indicative
poorer
prognosis.
Univariate
multivariate
Cox
models
further
identified
as
an
independent
predictor
based
other
factors
showed
high
level
predictive
accuracy.
Moreover,
prolonged
STAD.
In
patients,
chemoradiotherapy,
chemotherapy,
chemoradiotherapy
may
improve
Our
observations
reveal
notable
connection
neoantigens,
genes.ConclusionsThe
variations
are
controlling
could
act
promising
biomarker
impacts
prognosis
specific
cancers
like
LGG.
Язык: Английский
Graphene and its hybrid nanocomposite: A Metamorphoses elevation in the field of tissue engineering
Heliyon,
Год журнала:
2024,
Номер
10(13), С. e33542 - e33542
Опубликована: Июнь 25, 2024
Язык: Английский
Borneol-Functionalized Macrophage Membrane-Encapsulated Mesoporous Selenium Nanoparticles Loaded with Resveratrol for the Treatment of Spinal Cord Injury
Xiaobang Liu,
Jiaqun Du,
Junpeng Sun
и другие.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(46), С. 63170 - 63185
Опубликована: Ноя. 8, 2024
Spinal
cord
injury
(SCI)
is
a
serious
neurological
disease
that
can
result
in
paralysis.
After
SCI
occurs,
the
blood–spinal
barrier
(BSCB)
disrupted,
and
permeability
transiently
elevated.
However,
of
BSCB
returns
to
normal
over
time,
which
prevents
many
drugs
from
being
used
subsequent
treatments.
In
this
study,
we
designed
borneol-functionalized
macrophage
membrane
encapsulating
mesoporous
selenium
nanoparticles
loaded
with
resveratrol
(MSe-Res-BMMs)
for
treatment.
vivo
animal
experiments
vitro
cell
demonstrated
MSe-Res-BMMs
were
able
protect
neurons
ferroptosis
by
reducing
ROS
levels
increasing
glutathione
peroxidase-4
(GPx-4)
activity.
addition,
treatment
also
reduced
ROS-induced
inflammation
apoptosis
decreasing
expression
inflammatory
factor
IL-1β
apoptotic
Cleaved
Caspase-3
at
site
injury.
Therefore,
are
expected
provide
new
therapeutic
options
Язык: Английский
Cytomorphological assessment of the effect of selenium nanoparticles on SPEV-2 oncovirus cells
Bilnur Sayavush Kizi Mamedova,
Kristina Yurievna Peterson,
Marina Albertovna Gabrielyan
и другие.
Journal Of Advanced Pharmacy Education And Research,
Год журнала:
2024,
Номер
14(1), С. 84 - 90
Опубликована: Янв. 1, 2024
Язык: Английский
Hollow Mesoporous Selenium Nanoparticles Loaded with Pyrotinib and Coated with Trastuzumab-Functionalized Albumin for Targeted Therapy of HER2-Positive Breast Cancer
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
This
study
aimed
to
develop
trastuzumab
(HCT)-functionalized
albumin
(BSA)-coated,
pyrotinib
(Ptb)-loaded
hollow
mesoporous
selenium
(HSE)
nanoparticles
(HBHSEP)
for
the
targeted
delivery
of
HER2-positive
breast
cancer.
Characterization
pharmaceutical
properties
in
vitro
revealed
that
HBHSEP
was
well
dispersed,
and
particle
size
172
±
3.4
nm.
In
release
experiments
effectively
controlled
Ptb
tumor
microenvironment
(high
glutathione
concentration),
with
a
cumulative
rate
86.5
4.2%
over
48
h.
Cell
uptake
vivo
imaging
confirmed
have
good
tumor-targeting
ability.
The
results
cell
experiments,
such
as
MTT,
flow
cytometry,
immunofluorescence
staining,
antitumor
can
significantly
promote
apoptosis
SK-BR-3
cells
inhibit
their
proliferation.
These
findings
strongly
show
may
be
an
effective
treatment
Язык: Английский