Effects of Intermittent Fasting on Liver Steatosis and Fibrosis, Serum FGF-21 and Autophagy Markers in Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized Controlled Trial
Life,
Год журнала:
2025,
Номер
15(5), С. 696 - 696
Опубликована: Апрель 25, 2025
Background:
This
randomized
controlled
study
sought
to
determine
the
effect
of
intermittent
fasting
on
anthropometric
measurements,
fibroblast
growth
factor
(FGF)-21,
and
autophagy
markers,
as
well
hepatic
steatosis
fibrosis
levels
in
overweight
or
obese
patients
with
metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD).
Methods:
Patients
were
randomly
assigned
into
two
groups:
received
a
dietary
treatment
involving
22–25
kcal/kg/day
energy
for
8
weeks
followed
same
intervention
16:8
pattern.
The
extent
was
determined
using
transient
elastography
FibroScan®
device.
attenuation
parameter
(CAP)
stiffness
measurement
(LSM),
by
elastography,
reflect
fibrosis,
respectively.
In
duplicate,
serum
FGF-21,
Beclin-1,
ATG-5
enzyme-linked
immunosorbent
assay.
Results:
included
48
mean
age
48.2
±
1.4
years
(27
female
21
male).
Improvements
CAP
LSM
decrease
FGF-21
found
both
groups
(p
<
0.05).
Changes
higher
+
time-restricted
diet
group
Autophagy-related
protein
(ATG)-5
increased
only
[(0.74
(0.46–1.29)
ng/mL
vs.
0.95
(0.73–1.32)
ng/mL,
p
=
0.03].
Conclusions:
Intermittent
potentially
practical
management
MAFLD.
particular,
changes
indicate
potential
regulate
processes
autophagy.
However,
methodological
limitations
should
be
taken
consideration
when
interpreting
results.
Язык: Английский
Fasting alleviates bleomycin-induced lung inflammation and fibrosis via decreased Tregs and monocytes
Advances in Medical Sciences,
Год журнала:
2024,
Номер
69(2), С. 303 - 311
Опубликована: Июль 9, 2024
Язык: Английский
Intermittent fasting as a treatment for obesity in young people: a scoping review
npj Metabolic Health and Disease,
Год журнала:
2024,
Номер
2(1)
Опубликована: Дек. 30, 2024
Intermittent
fasting
focuses
on
the
timing
of
eating
rather
than
diet
quality
or
energy
intake,
with
evidence
supporting
its
effects
weight
loss
and
improvements
in
cardiometabolic
outcomes
adults
obesity.
However,
there
is
limited
for
feasibility
efficacy
young
people.
To
address
this,
a
scoping
review
was
conducted
to
examine
intermittent
regimens
individuals
aged
10
25
treatment
obesity
focusing
methodology,
intervention
parameters,
outcomes,
adherence,
feasibility,
efficacy.
Due
paucity
this
age
group,
adequately
assess
all
published
studies
category,
regardless
status
intention,
were
included
review.
The
34
(28
interventional
6
observational
studies)
893
participants
12
25.
Interventions
varied
9
cohorts
utilizing
as
an
treatment.
Thirteen
utilized
8-h
time-restricted
eating.
Primary
risk
factors
(7/28),
anthropometric
measurements
body
composition
(5/28),
muscular
performance
(4/28),
(1/28),
others
(4/28).
All
people
reported
some
degree
loss,
although
comparator
groups
significantly.
This
underscores
various
utilizations
group
highlights
potential
treating
findings
emphasize
need
rigorous
standardized
frameworks
ensure
comparability
determine
fasting's
practicality
depending
outcome
interest.
Язык: Английский
Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4424 - 4424
Опубликована: Дек. 23, 2024
Dietary
restriction
(DR)
has
been
reported
to
be
a
significant
intervention
that
influences
lipid
metabolism
and
potentially
modulates
the
aging
process
in
wide
range
of
organisms.
Lipid
plays
pivotal
role
regulation
longevity.
In
this
review,
we
summarize
studies
on
relation
DR.
As
potent
slow
down
aging,
DR
demonstrated
promising
effects
metabolism,
influencing
processes
across
various
species.
The
current
review
focuses
relationships
among
DR-related
molecular
signaling
proteins
such
as
sirtuins,
pathways
target
rapamycin
insulin/insulin-like
growth
factor
(IGF)-1,
aging.
Furthermore,
presents
research
results
diet-associated
changes
cell
membrane
lipids
alterations
caused
by
commensal
bacteria,
highlighting
importance
Overall,
explores
interplay
between
diet,
while
presenting
untapped
areas
for
further
understanding
process.
Язык: Английский
Intermittent Fasting in Youth: A Scoping Review
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Intermittent
fasting
(IF)
focuses
on
the
timing
of
eating
rather
than
diet
quality
or
energy
intake,
with
evidence
supporting
its
effects
weight
loss
and
cardiometabolic
outcomes
in
adults.
However,
there
is
limited
for
efficacy
adolescents
emerging
To
address
this,
a
scoping
review
examined
IF
regimens
individuals
aged
10
to
25,
focusing
methodology,
intervention
parameters,
outcomes,
adherence,
feasibility,
efficacy.
The
included
39
studies
731
participants
15
25.
Methodologies
varied,
18
time-restricted
others
requiring
caloric
restriction.
Primary
risk
factors
(11/29),
body
composition
(9/29),
anthropometric
measurements
(8/29),
feasibility
(2/29).
Most
reported
significant
loss.
This
underscores
IF's
potential
treating
obesity
this
age
group
but
highlights
need
rigorous
standardized
frameworks
ensure
comparability
determine
practicality
group.
Язык: Английский