Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(1), С. 325 - 336
Опубликована: Янв. 16, 2025
Nanoparticles
have
become
a
transforming
platform
in
drug
delivery
systems.
Their
remarkable
advancement
over
traditional
methods
builds
upon
an
improvement
bioavailability,
stability,
and
controlled
of
therapeutic
agents.
Here,
we
discuss
the
broad
spectrum
potential
nanoparticle-based
Challenges,
innovations,
surface
modification
strategies
that
affect
their
clinical
translation
are
discussed.
Notwithstanding
they
present,
challenges
including
biocompatibility,
toxicity,
targeting
efficiency
persist
restricting
extensive
utilization.
The
review
emphasizes
recent
advancements,
stimuli-responsive
nanoparticles,
which
provide
release
reaction
to
environmental
triggers,
as
well
targeted
delivery,
facilitates
selective
accumulation
agents
at
designated
sites
disease.
Besides,
techniques,
such
PEGylation,
ligand
conjugation,
charge
modulation,
been
highly
promising
improving
stability
reducing
immunogenicity,
enhancing
cellular
uptake.
future
systems
based
on
nanoparticles
will
address
these
through
new
innovations
nanoparticle
design
effect
more
effective
treatments.
While
research
advances,
likely
bring
revolution
personalized
medicine,
tailoring
medical
therapy
for
different
diseases
with
minimal
side
effects
better
patient
outcomes.
Язык: Английский
Revolutionizing cellular energy: The convergence of mitochondrial dynamics and delivery technologies
Mitochondrion,
Год журнала:
2024,
Номер
76, С. 101873 - 101873
Опубликована: Март 17, 2024
Язык: Английский
Nano-based formulations of thymoquinone are new approaches for psoriasis treatment: a literature review
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 12, 2024
Psoriasis,
a
persistent
immune-mediated
inflammatory
skin
condition,
affects
approximately
2-3%
of
the
global
population.
Current
treatments
for
psoriasis
are
fraught
with
limitations,
including
adverse
effects,
high
costs,
and
diminishing
efficacy
over
time.
Thymoquinone
(TQ),
derived
from
Nigella
sativa
seeds,
exhibits
promising
anti-inflammatory,
antioxidant,
immunomodulatory
properties
that
could
prove
beneficial
in
managing
psoriasis.
However,
TQ’s
hydrophobic
nature
poor
bioavailability
have
hindered
its
usefulness
as
therapeutic
agent.
Recent
research
has
strategically
addressed
these
challenges
by
developing
nano-thymoquinone
(nano-TQ)
formulations
to
enhance
delivery
treating
Preclinical
studies
employing
mouse
models
demonstrated
nano-TQ
effectively
mitigates
inflammation,
erythema,
scaling,
epidermal
thickness,
cytokine
levels
psoriatic
lesions.
Various
formulations,
nanoemulsions,
lipid
vesicles,
nanostructured
carriers,
ethosomes,
been
explored
improve
solubility,
facilitate
penetration,
ensure
sustained
release,
achieve
site-specific
targeting.
Although
clinical
trials
currently
scarce,
outcomes
vitro
animal
promising.
The
potential
co-delivery
other
anti-psoriatic
agents
also
presents
avenues
further
investigation.
Язык: Английский
Triphenylphosphine-Modified IridiumIII, RhodiumIII, and RutheniumII Complexes to Achieve Enhanced Anticancer Selectivity by Targeting Mitochondria
Zhe Liu,
Hanxiu Fu,
Heqian Dong
и другие.
Inorganic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
The
incorporation
of
an
organelle-targeting
moiety
into
compounds
has
proven
to
be
effective
strategy
in
the
development
targeted
anticancer
drugs.
We
herein
report
synthesis,
characterization,
and
biological
evaluation
novel
triphenylphosphine-modified
half-sandwich
iridiumIII,
rhodiumIII,
rutheniumII
complexes.
primary
goal
was
enhance
selectivity
through
mitochondrial
targeting.
All
these
complexes
exhibited
promising
cytotoxicity
micromolar
range
(5.13–23.22)
against
A549
HeLa
cancer
cell
lines,
surpassing
activity
comparative
that
lack
triphenylphosphine
moiety.
Noteworthy
is
their
good
toward
cells
compared
normal
BEAS-2B
cells,
underscored
by
index
ranging
from
7.3
>19.5.
Mechanistically,
primarily
target
mitochondria
rather
than
interacting
with
DNA.
targeting
triggering
dysfunction
were
confirmed
using
both
confocal
microscopy
flow
cytometry.
Their
ability
depolarize
membrane
potential
(MMP)
reactive
oxygen
species
(ROS)
observed,
thereby
leading
intrinsic
apoptotic
pathways.
Moreover,
lead
cycle
arrest
G2/M
phase
demonstrated
antimigration
effects,
significantly
inhibiting
migration
wound-healing
assays.
Язык: Английский