Triphenylphosphine-Modified IridiumIII, RhodiumIII, and RutheniumII Complexes to Achieve Enhanced Anticancer Selectivity by Targeting Mitochondria DOI
Zhe Liu,

Hanxiu Fu,

Heqian Dong

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The incorporation of an organelle-targeting moiety into compounds has proven to be effective strategy in the development targeted anticancer drugs. We herein report synthesis, characterization, and biological evaluation novel triphenylphosphine-modified half-sandwich iridiumIII, rhodiumIII, rutheniumII complexes. primary goal was enhance selectivity through mitochondrial targeting. All these complexes exhibited promising cytotoxicity micromolar range (5.13–23.22) against A549 HeLa cancer cell lines, surpassing activity comparative that lack triphenylphosphine moiety. Noteworthy is their good toward cells compared normal BEAS-2B cells, underscored by index ranging from 7.3 >19.5. Mechanistically, primarily target mitochondria rather than interacting with DNA. targeting triggering dysfunction were confirmed using both confocal microscopy flow cytometry. Their ability depolarize membrane potential (MMP) reactive oxygen species (ROS) observed, thereby leading intrinsic apoptotic pathways. Moreover, lead cycle arrest G2/M phase demonstrated antimigration effects, significantly inhibiting migration wound-healing assays.

Language: Английский

Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics DOI
Tasawar Abbas,

Fatima Kanwar,

Hazima Tariq

et al.

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 325 - 336

Published: Jan. 16, 2025

Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.

Language: Английский

Citations

0
Revolutionizing cellular energy: The convergence of mitochondrial dynamics and delivery technologies DOI
Dilpreet Singh

Mitochondrion, Journal Year: 2024, Volume and Issue: 76, P. 101873 - 101873

Published: March 17, 2024

Language: Английский

Citations

2
Nano-based formulations of thymoquinone are new approaches for psoriasis treatment: a literature review DOI Creative Commons
Amir Modarresi Chahardehi,

Hamid Reza Ojaghi,

Hossein Motedayyen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 12, 2024

Psoriasis, a persistent immune-mediated inflammatory skin condition, affects approximately 2-3% of the global population. Current treatments for psoriasis are fraught with limitations, including adverse effects, high costs, and diminishing efficacy over time. Thymoquinone (TQ), derived from Nigella sativa seeds, exhibits promising anti-inflammatory, antioxidant, immunomodulatory properties that could prove beneficial in managing psoriasis. However, TQ’s hydrophobic nature poor bioavailability have hindered its usefulness as therapeutic agent. Recent research has strategically addressed these challenges by developing nano-thymoquinone (nano-TQ) formulations to enhance delivery treating Preclinical studies employing mouse models demonstrated nano-TQ effectively mitigates inflammation, erythema, scaling, epidermal thickness, cytokine levels psoriatic lesions. Various formulations, nanoemulsions, lipid vesicles, nanostructured carriers, ethosomes, been explored improve solubility, facilitate penetration, ensure sustained release, achieve site-specific targeting. Although clinical trials currently scarce, outcomes vitro animal promising. The potential co-delivery other anti-psoriatic agents also presents avenues further investigation.

Language: Английский

Citations

1
Triphenylphosphine-Modified IridiumIII, RhodiumIII, and RutheniumII Complexes to Achieve Enhanced Anticancer Selectivity by Targeting Mitochondria DOI
Zhe Liu,

Hanxiu Fu,

Heqian Dong

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The incorporation of an organelle-targeting moiety into compounds has proven to be effective strategy in the development targeted anticancer drugs. We herein report synthesis, characterization, and biological evaluation novel triphenylphosphine-modified half-sandwich iridiumIII, rhodiumIII, rutheniumII complexes. primary goal was enhance selectivity through mitochondrial targeting. All these complexes exhibited promising cytotoxicity micromolar range (5.13–23.22) against A549 HeLa cancer cell lines, surpassing activity comparative that lack triphenylphosphine moiety. Noteworthy is their good toward cells compared normal BEAS-2B cells, underscored by index ranging from 7.3 >19.5. Mechanistically, primarily target mitochondria rather than interacting with DNA. targeting triggering dysfunction were confirmed using both confocal microscopy flow cytometry. Their ability depolarize membrane potential (MMP) reactive oxygen species (ROS) observed, thereby leading intrinsic apoptotic pathways. Moreover, lead cycle arrest G2/M phase demonstrated antimigration effects, significantly inhibiting migration wound-healing assays.

Language: Английский

Citations

1